5ELV

Crystal structure of the GluA2 ligand-binding domain (S1S2J-L504-N775) in complex with glutamate and BPAM-521 at 1.92 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue SO4 A 301

Chain	Residue
A	SER140
A	LYS144
A	ARG148
A	HOH404
A	HOH409
A	HOH541

---

site_id	AC2
Number of Residues	6
Details	binding site for residue SO4 A 302

Chain	Residue
A	HOH456
A	HOH461
B	LYS183
A	ARG31
A	HOH408
A	HOH422

---

site_id	AC3
Number of Residues	3
Details	binding site for residue SO4 A 303

Chain	Residue
A	ARG149
A	HOH474
B	LYS240

---

site_id	AC4
Number of Residues	4
Details	binding site for residue GOL A 304

Chain	Residue
A	ARG148
A	TRP159
A	ARG163
A	HOH558

---

site_id	AC5
Number of Residues	6
Details	binding site for residue GOL A 305

Chain	Residue
A	SER108
A	SER194
A	THR195
A	GLU198
A	ASN214
A	HOH465

---

site_id	AC6
Number of Residues	2
Details	binding site for residue CL A 306

Chain	Residue
A	ARG163
B	HOH577

---

site_id	AC7
Number of Residues	2
Details	binding site for residue CL A 307

Chain	Residue
A	LYS21
A	ASN22

---

site_id	AC8
Number of Residues	2
Details	binding site for residue ACT A 308

Chain	Residue
A	ALA153
B	LYS249

---

site_id	AC9
Number of Residues	2
Details	binding site for residue ACT A 309

Chain	Residue
A	ASP257
A	HOH431

---

site_id	AD1
Number of Residues	4
Details	binding site for residue ACT A 310

Chain	Residue
A	ASP248
B	ASN214
B	ASP216
B	SER217

---

site_id	AD2
Number of Residues	5
Details	binding site for residue ACT A 311

Chain	Residue
A	ASP38
A	GLU42
A	LEU250
A	LYS253
B	LYS21

---

site_id	AD3
Number of Residues	13
Details	binding site for residue 5PX A 312

Chain	Residue
A	PRO105
A	SER108
A	SER217
A	LYS218
A	GLY219
A	HOH545
B	LYS104
B	PRO105
B	PHE106
B	MET107
B	SER108
B	SER242
B	5PX312

---

site_id	AD4
Number of Residues	12
Details	binding site for residue GLU A 313

Chain	Residue
A	TYR61
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	GLY141
A	SER142
A	THR143
A	GLU193
A	HOH437
A	HOH444
A	HOH473

---

site_id	AD5
Number of Residues	6
Details	binding site for residue SO4 B 301

Chain	Residue
B	SER140
B	LYS144
B	ARG148
B	HOH411
B	HOH430
B	HOH458

---

site_id	AD6
Number of Residues	5
Details	binding site for residue GOL B 302

Chain	Residue
B	SER108
B	SER194
B	GLU198
B	ASN214
B	HOH407

---

site_id	AD7
Number of Residues	4
Details	binding site for residue GOL B 303

Chain	Residue
B	ARG148
B	TRP159
B	ARG163
B	ACT307

---

site_id	AD8
Number of Residues	2
Details	binding site for residue CL B 304

Chain	Residue
B	LYS4
B	THR5

---

site_id	AD9
Number of Residues	2
Details	binding site for residue ACT B 305

Chain	Residue
B	LYS82
B	LYS116

---

site_id	AE1
Number of Residues	3
Details	binding site for residue ACT B 306

Chain	Residue
B	ASP58
B	LYS60
B	ASN72

---

site_id	AE2
Number of Residues	3
Details	binding site for residue ACT B 307

Chain	Residue
B	LYS144
B	ARG163
B	GOL303

---

site_id	AE3
Number of Residues	4
Details	binding site for residue ACT B 308

Chain	Residue
B	SER123
B	ALA124
B	GLY213
B	HOH422

---

site_id	AE4
Number of Residues	5
Details	binding site for residue ACT B 309

Chain	Residue
B	LYS240
B	HOH504
A	TYR94
B	HIS46
B	ALA237

---

site_id	AE5
Number of Residues	5
Details	binding site for residue PEG B 310

Chain	Residue
B	GLU27
B	GLY28
B	ARG31
B	LYS52
B	HOH453

---

site_id	AE6
Number of Residues	4
Details	binding site for residue PEG B 311

Chain	Residue
A	ARG203
A	LYS258
B	HIS23
B	ARG31

---

site_id	AE7
Number of Residues	12
Details	binding site for residue 5PX B 312

Chain	Residue
A	LYS104
A	PRO105
A	PHE106
A	MET107
A	SER108
A	SER242
A	5PX312
B	PRO105
B	SER108
B	SER217
B	LYS218
B	GLY219

---

site_id	AE8
Number of Residues	12
Details	binding site for residue GLU B 313

Chain	Residue
B	TYR61
B	PRO89
B	LEU90
B	THR91
B	ARG96
B	GLY141
B	SER142
B	THR143
B	GLU193
B	HOH462
B	HOH465
B	HOH467

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
A	PRO89
B	SER142
B	THR143
B	GLU193
A	THR91
A	ARG96
A	SER142
A	THR143
A	GLU193
B	PRO89
B	THR91
B	ARG96

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ARG64
A	ARG148
A	LYS240
B	ARG64
B	ARG148
B	LYS240

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ILE121
B	ILE121

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER150
B	SER150

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER184
B	SER184

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN3
B	ASN3

---