5EKD
Human mitochondrial tryptophanyl-tRNA synthetase bound by indolmycin and Mn*ATP.
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0001570 | biological_process | vasculogenesis |
A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
A | 0004830 | molecular_function | tryptophan-tRNA ligase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005739 | cellular_component | mitochondrion |
A | 0005759 | cellular_component | mitochondrial matrix |
A | 0005886 | cellular_component | plasma membrane |
A | 0006412 | biological_process | translation |
A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
A | 0006436 | biological_process | tryptophanyl-tRNA aminoacylation |
A | 0045766 | biological_process | positive regulation of angiogenesis |
A | 0070183 | biological_process | mitochondrial tryptophanyl-tRNA aminoacylation |
B | 0000166 | molecular_function | nucleotide binding |
B | 0001570 | biological_process | vasculogenesis |
B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
B | 0004830 | molecular_function | tryptophan-tRNA ligase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0005654 | cellular_component | nucleoplasm |
B | 0005739 | cellular_component | mitochondrion |
B | 0005759 | cellular_component | mitochondrial matrix |
B | 0005886 | cellular_component | plasma membrane |
B | 0006412 | biological_process | translation |
B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
B | 0006436 | biological_process | tryptophanyl-tRNA aminoacylation |
B | 0045766 | biological_process | positive regulation of angiogenesis |
B | 0070183 | biological_process | mitochondrial tryptophanyl-tRNA aminoacylation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 12 |
Details | binding site for residue 5BX A 401 |
Chain | Residue |
A | PHE38 |
A | ATP402 |
A | HOH529 |
A | HOH555 |
A | SER39 |
A | GLY40 |
A | GLN42 |
A | HIS77 |
A | TYR160 |
A | GLN164 |
A | ASP167 |
A | GLN182 |
site_id | AC2 |
Number of Residues | 28 |
Details | binding site for residue ATP A 402 |
Chain | Residue |
A | ILE41 |
A | GLN42 |
A | HIS48 |
A | GLY50 |
A | ASN51 |
A | GLY54 |
A | VAL178 |
A | GLY179 |
A | ASP181 |
A | GLN182 |
A | MET214 |
A | LYS215 |
A | LYS216 |
A | VAL217 |
A | LYS226 |
A | MET227 |
A | SER228 |
A | LYS229 |
A | SER230 |
A | 5BX401 |
A | MN403 |
A | HOH517 |
A | HOH529 |
A | HOH530 |
A | HOH555 |
A | HOH605 |
A | HOH689 |
A | HOH691 |
site_id | AC3 |
Number of Residues | 4 |
Details | binding site for residue MN A 403 |
Chain | Residue |
A | ATP402 |
A | HOH529 |
A | HOH555 |
A | HOH691 |
site_id | AC4 |
Number of Residues | 6 |
Details | binding site for residue MN A 404 |
Chain | Residue |
A | GLU312 |
A | GLU312 |
A | HOH533 |
A | HOH533 |
A | HOH703 |
A | HOH703 |
site_id | AC5 |
Number of Residues | 15 |
Details | binding site for residue 5BX B 401 |
Chain | Residue |
B | PHE38 |
B | GLY40 |
B | GLN42 |
B | VAL74 |
B | HIS77 |
B | TYR160 |
B | GLN164 |
B | ASP167 |
B | ILE168 |
B | VAL176 |
B | VAL178 |
B | GLN182 |
B | ATP402 |
B | HOH522 |
B | HOH618 |
site_id | AC6 |
Number of Residues | 29 |
Details | binding site for residue ATP B 402 |
Chain | Residue |
B | ILE41 |
B | GLN42 |
B | HIS48 |
B | GLY50 |
B | ASN51 |
B | GLY54 |
B | VAL178 |
B | GLY179 |
B | ASP181 |
B | GLN182 |
B | MET214 |
B | LYS215 |
B | LYS216 |
B | VAL217 |
B | LYS226 |
B | MET227 |
B | SER228 |
B | LYS229 |
B | SER230 |
B | 5BX401 |
B | MN403 |
B | HOH522 |
B | HOH525 |
B | HOH571 |
B | HOH595 |
B | HOH611 |
B | HOH618 |
B | HOH630 |
B | HOH678 |
site_id | AC7 |
Number of Residues | 4 |
Details | binding site for residue MN B 403 |
Chain | Residue |
B | ATP402 |
B | HOH522 |
B | HOH618 |
B | HOH678 |
site_id | AC8 |
Number of Residues | 6 |
Details | binding site for residue MN B 404 |
Chain | Residue |
B | GLU312 |
B | HOH511 |
B | HOH511 |
B | HOH705 |
B | HOH705 |
B | GLU312 |
site_id | AC9 |
Number of Residues | 7 |
Details | binding site for residue GOL B 405 |
Chain | Residue |
A | THR121 |
A | SER124 |
A | TRP125 |
B | THR121 |
B | SER124 |
B | TRP125 |
B | HOH582 |
site_id | AD1 |
Number of Residues | 4 |
Details | binding site for residue GOL B 406 |
Chain | Residue |
B | GLU344 |
B | TYR347 |
B | HOH637 |
B | HOH670 |
Functional Information from PROSITE/UniProt
site_id | PS00178 |
Number of Residues | 10 |
Details | AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. P..TGiLHLGNY |
Chain | Residue | Details |
A | PRO43-TYR52 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0007744|PDB:5EKD |
Chain | Residue | Details |
A | GLN42 | |
B | GLY179 | |
B | VAL217 | |
B | LYS226 | |
A | HIS48 | |
A | ASP167 | |
A | GLY179 | |
A | VAL217 | |
A | LYS226 | |
B | GLN42 | |
B | HIS48 | |
B | ASP167 |