5EKD
Human mitochondrial tryptophanyl-tRNA synthetase bound by indolmycin and Mn*ATP.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0001570 | biological_process | vasculogenesis |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004830 | molecular_function | tryptophan-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006412 | biological_process | translation |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006436 | biological_process | tryptophanyl-tRNA aminoacylation |
| A | 0016874 | molecular_function | ligase activity |
| A | 0045766 | biological_process | positive regulation of angiogenesis |
| A | 0070183 | biological_process | mitochondrial tryptophanyl-tRNA aminoacylation |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0001570 | biological_process | vasculogenesis |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004830 | molecular_function | tryptophan-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006412 | biological_process | translation |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006436 | biological_process | tryptophanyl-tRNA aminoacylation |
| B | 0016874 | molecular_function | ligase activity |
| B | 0045766 | biological_process | positive regulation of angiogenesis |
| B | 0070183 | biological_process | mitochondrial tryptophanyl-tRNA aminoacylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue 5BX A 401 |
| Chain | Residue |
| A | PHE38 |
| A | ATP402 |
| A | HOH529 |
| A | HOH555 |
| A | SER39 |
| A | GLY40 |
| A | GLN42 |
| A | HIS77 |
| A | TYR160 |
| A | GLN164 |
| A | ASP167 |
| A | GLN182 |
| site_id | AC2 |
| Number of Residues | 28 |
| Details | binding site for residue ATP A 402 |
| Chain | Residue |
| A | ILE41 |
| A | GLN42 |
| A | HIS48 |
| A | GLY50 |
| A | ASN51 |
| A | GLY54 |
| A | VAL178 |
| A | GLY179 |
| A | ASP181 |
| A | GLN182 |
| A | MET214 |
| A | LYS215 |
| A | LYS216 |
| A | VAL217 |
| A | LYS226 |
| A | MET227 |
| A | SER228 |
| A | LYS229 |
| A | SER230 |
| A | 5BX401 |
| A | MN403 |
| A | HOH517 |
| A | HOH529 |
| A | HOH530 |
| A | HOH555 |
| A | HOH605 |
| A | HOH689 |
| A | HOH691 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue MN A 403 |
| Chain | Residue |
| A | ATP402 |
| A | HOH529 |
| A | HOH555 |
| A | HOH691 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue MN A 404 |
| Chain | Residue |
| A | GLU312 |
| A | GLU312 |
| A | HOH533 |
| A | HOH533 |
| A | HOH703 |
| A | HOH703 |
| site_id | AC5 |
| Number of Residues | 15 |
| Details | binding site for residue 5BX B 401 |
| Chain | Residue |
| B | PHE38 |
| B | GLY40 |
| B | GLN42 |
| B | VAL74 |
| B | HIS77 |
| B | TYR160 |
| B | GLN164 |
| B | ASP167 |
| B | ILE168 |
| B | VAL176 |
| B | VAL178 |
| B | GLN182 |
| B | ATP402 |
| B | HOH522 |
| B | HOH618 |
| site_id | AC6 |
| Number of Residues | 29 |
| Details | binding site for residue ATP B 402 |
| Chain | Residue |
| B | ILE41 |
| B | GLN42 |
| B | HIS48 |
| B | GLY50 |
| B | ASN51 |
| B | GLY54 |
| B | VAL178 |
| B | GLY179 |
| B | ASP181 |
| B | GLN182 |
| B | MET214 |
| B | LYS215 |
| B | LYS216 |
| B | VAL217 |
| B | LYS226 |
| B | MET227 |
| B | SER228 |
| B | LYS229 |
| B | SER230 |
| B | 5BX401 |
| B | MN403 |
| B | HOH522 |
| B | HOH525 |
| B | HOH571 |
| B | HOH595 |
| B | HOH611 |
| B | HOH618 |
| B | HOH630 |
| B | HOH678 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue MN B 403 |
| Chain | Residue |
| B | ATP402 |
| B | HOH522 |
| B | HOH618 |
| B | HOH678 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue MN B 404 |
| Chain | Residue |
| B | GLU312 |
| B | HOH511 |
| B | HOH511 |
| B | HOH705 |
| B | HOH705 |
| B | GLU312 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 405 |
| Chain | Residue |
| A | THR121 |
| A | SER124 |
| A | TRP125 |
| B | THR121 |
| B | SER124 |
| B | TRP125 |
| B | HOH582 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 406 |
| Chain | Residue |
| B | GLU344 |
| B | TYR347 |
| B | HOH637 |
| B | HOH670 |
Functional Information from PROSITE/UniProt
| site_id | PS00178 |
| Number of Residues | 10 |
| Details | AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. P..TGiLHLGNY |
| Chain | Residue | Details |
| A | PRO43-TYR52 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0007744|PDB:5EKD |
| Chain | Residue | Details |
| A | GLN42 | |
| B | GLY179 | |
| B | VAL217 | |
| B | LYS226 | |
| A | HIS48 | |
| A | ASP167 | |
| A | GLY179 | |
| A | VAL217 | |
| A | LYS226 | |
| B | GLN42 | |
| B | HIS48 | |
| B | ASP167 |
