5EH2

Human PRDM9 allele-A ZnF Domain with Associated Recombination Hotspot DNA Sequence III

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN E 1001

Chain	Residue
E	CYS721
E	CYS724
E	HIS737
E	HIS741

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN E 1002

Chain	Residue
E	CYS749
E	CYS752
E	HIS765
E	HIS769

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN E 1003

Chain	Residue
E	CYS780
E	HIS793
E	HIS797
E	CYS777

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN E 1004

Chain	Residue
E	CYS805
E	CYS808
E	HIS821
E	HIS825

---

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN F 1001

Chain	Residue
F	CYS721
F	CYS724
F	HIS737
F	HIS741

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN F 1002

Chain	Residue
F	CYS749
F	CYS752
F	HIS765
F	HIS769

---

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN F 1003

Chain	Residue
F	CYS777
F	CYS780
F	HIS793
F	HIS797

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN F 1004

Chain	Residue
F	CYS805
F	CYS808
F	HIS821
F	HIS825

---

Functional Information from PROSITE/UniProt

site_id	PS00028
Number of Residues	21
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cre..CgrgFsnkshllrHqrt..H

Chain	Residue	Details
E	CYS721-HIS741
E	CYS749-HIS769
E	CYS777-HIS797
E	CYS805-HIS825
E	CYS833-HIS853

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	44
Details	ZN_FING: C2H2-type 9 => ECO:0000255|PROSITE-ProRule:PRU00042

Chain	Residue	Details
E	TYR719-HIS741
F	TYR719-HIS741

---

site_id	SWS_FT_FI2
Number of Residues	44
Details	ZN_FING: C2H2-type 10 => ECO:0000255|PROSITE-ProRule:PRU00042

Chain	Residue	Details
E	TYR747-HIS769
F	TYR747-HIS769

---

site_id	SWS_FT_FI3
Number of Residues	44
Details	ZN_FING: C2H2-type 11 => ECO:0000255|PROSITE-ProRule:PRU00042

Chain	Residue	Details
E	TYR775-HIS797
F	TYR775-HIS797

---

site_id	SWS_FT_FI4
Number of Residues	44
Details	ZN_FING: C2H2-type 12 => ECO:0000255|PROSITE-ProRule:PRU00042

Chain	Residue	Details
E	TYR803-HIS825
F	TYR803-HIS825

---

site_id	SWS_FT_FI5
Number of Residues	44
Details	ZN_FING: C2H2-type 13 => ECO:0000255|PROSITE-ProRule:PRU00042

Chain	Residue	Details
E	TYR831-HIS853
F	TYR831-HIS853

---

site_id	SWS_FT_FI6
Number of Residues	32
Details	BINDING: BINDING => ECO:0000269|PubMed:26833727, ECO:0007744|PDB:5EGB, ECO:0007744|PDB:5EH2, ECO:0007744|PDB:5EI9

Chain	Residue	Details
E	CYS721
E	CYS780
E	HIS793
E	HIS797
E	CYS805
E	CYS808
E	HIS821
E	HIS825
F	CYS721
F	CYS724
F	HIS737
E	CYS724
F	HIS741
F	CYS749
F	CYS752
F	HIS765
F	HIS769
F	CYS777
F	CYS780
F	HIS793
F	HIS797
F	CYS805
E	HIS737
F	CYS808
F	HIS821
F	HIS825
E	HIS741
E	CYS749
E	CYS752
E	HIS765
E	HIS769
E	CYS777

---