5EH2
Human PRDM9 allele-A ZnF Domain with Associated Recombination Hotspot DNA Sequence III
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN E 1001 |
| Chain | Residue |
| E | CYS721 |
| E | CYS724 |
| E | HIS737 |
| E | HIS741 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN E 1002 |
| Chain | Residue |
| E | CYS749 |
| E | CYS752 |
| E | HIS765 |
| E | HIS769 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN E 1003 |
| Chain | Residue |
| E | CYS780 |
| E | HIS793 |
| E | HIS797 |
| E | CYS777 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN E 1004 |
| Chain | Residue |
| E | CYS805 |
| E | CYS808 |
| E | HIS821 |
| E | HIS825 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN F 1001 |
| Chain | Residue |
| F | CYS721 |
| F | CYS724 |
| F | HIS737 |
| F | HIS741 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN F 1002 |
| Chain | Residue |
| F | CYS749 |
| F | CYS752 |
| F | HIS765 |
| F | HIS769 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN F 1003 |
| Chain | Residue |
| F | CYS777 |
| F | CYS780 |
| F | HIS793 |
| F | HIS797 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN F 1004 |
| Chain | Residue |
| F | CYS805 |
| F | CYS808 |
| F | HIS821 |
| F | HIS825 |
Functional Information from PROSITE/UniProt
| site_id | PS00028 |
| Number of Residues | 21 |
| Details | ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cre..CgrgFsnkshllrHqrt..H |
| Chain | Residue | Details |
| E | CYS721-HIS741 | |
| E | CYS749-HIS769 | |
| E | CYS777-HIS797 | |
| E | CYS805-HIS825 | |
| E | CYS833-HIS853 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 44 |
| Details | Zinc finger: {"description":"C2H2-type 9","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 44 |
| Details | Zinc finger: {"description":"C2H2-type 10","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 44 |
| Details | Zinc finger: {"description":"C2H2-type 11","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 44 |
| Details | Zinc finger: {"description":"C2H2-type 12","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 180 |
| Details | Region: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"26833727","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 32 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26833727","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5EGB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EI9","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
