5EFQ

Crystal structure of human Cdk13/Cyclin K in complex with ADP-aluminum fluoride

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0016538	molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity
C	0004672	molecular_function	protein kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0016538	molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	binding site for residue ADP A 1101

Chain	Residue
A	ILE711
A	SER841
A	ASN842
A	LEU844
A	ASP855
A	HIS1018
A	AF31102
A	MG1103
A	MG1104
A	HOH1207
A	HOH1223
A	GLY714
A	HOH1224
A	HOH1226
A	HOH1227
A	HOH1232
A	THR715
A	ALA732
A	LYS734
A	PHE791
A	GLU792
A	MET794
A	ASP797

---

site_id	AC2
Number of Residues	8
Details	binding site for residue AF3 A 1102

Chain	Residue
A	ASP837
A	LYS839
A	ASN842
A	ASP855
A	ADP1101
A	MG1103
A	MG1104
A	HOH1207

---

site_id	AC3
Number of Residues	5
Details	binding site for residue MG A 1103

Chain	Residue
A	ASN842
A	ASP855
A	ADP1101
A	AF31102
A	HOH1207

---

site_id	AC4
Number of Residues	4
Details	binding site for residue MG A 1104

Chain	Residue
A	ASP855
A	ADP1101
A	AF31102
A	HOH1204

---

site_id	AC5
Number of Residues	24
Details	binding site for residue ADP C 1101

Chain	Residue
C	ILE711
C	GLU713
C	GLY714
C	THR715
C	ALA732
C	LYS734
C	PHE791
C	GLU792
C	MET794
C	ASP797
C	SER841
C	ASN842
C	LEU844
C	ASP855
C	HIS1018
C	AF31102
C	MG1103
C	MG1104
C	HOH1202
C	HOH1203
C	HOH1241
C	HOH1244
C	HOH1247
C	HOH1250

---

site_id	AC6
Number of Residues	8
Details	binding site for residue AF3 C 1102

Chain	Residue
C	ASP837
C	LYS839
C	ASN842
C	ASP855
C	ADP1101
C	MG1103
C	MG1104
C	HOH1203

---

site_id	AC7
Number of Residues	5
Details	binding site for residue MG C 1103

Chain	Residue
C	ASN842
C	ASP855
C	ADP1101
C	AF31102
C	HOH1203

---

site_id	AC8
Number of Residues	4
Details	binding site for residue MG C 1104

Chain	Residue
C	ASP855
C	ADP1101
C	AF31102
C	HOH1269

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGTYGQVYkArdkdtgem..........VALK

Chain	Residue	Details
A	ILE711-LYS734

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. FlHrDIKcsNILL

Chain	Residue	Details
A	PHE833-LEU845

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027

Chain	Residue	Details
A	ASP837
C	ASP837

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	ILE711
A	LYS734
C	ILE711
C	LYS734

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	TPO871
C	TPO871

---