5EA5
Crystal Structure of Inhibitor TMC-353121 in Complex with Prefusion RSV F Glycoprotein
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| F | 0019064 | biological_process | fusion of virus membrane with host plasma membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue NHE F 601 |
| Chain | Residue |
| F | PHE387 |
| F | PHE477 |
| F | TYR478 |
| F | ASP479 |
| F | ASN496 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | binding site for residue TM3 F 602 |
| Chain | Residue |
| F | ASP486 |
| F | ASP486 |
| F | GLU487 |
| F | GLU487 |
| F | GLU487 |
| F | PHE488 |
| F | PHE488 |
| F | PHE488 |
| F | ASP489 |
| F | LYS498 |
| F | LYS498 |
| F | TAR604 |
| F | PHE140 |
| F | PHE140 |
| F | PHE140 |
| F | ASP486 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 F 603 |
| Chain | Residue |
| F | ASN277 |
| F | ARG364 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue TAR F 604 |
| Chain | Residue |
| F | PHE137 |
| F | GLY139 |
| F | GLN354 |
| F | GLU356 |
| F | TM3602 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by host furin-like protease => ECO:0000269|PubMed:11493675, ECO:0000269|PubMed:12127793 |
| Chain | Residue | Details |
| F | ARG109 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by host furin-like protease => ECO:0000269|PubMed:11369882, ECO:0000269|PubMed:12127793 |
| Chain | Residue | Details |
| F | ARG136 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000269|PubMed:21586636 |
| Chain | Residue | Details |
| F | ASN27 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000269|PubMed:21586636, ECO:0000269|PubMed:28469033 |
| Chain | Residue | Details |
| F | ASN70 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000255 |
| Chain | Residue | Details |
| F | ASN116 | |
| F | ASN120 | |
| F | ASN126 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000269|PubMed:21586636, ECO:0000269|PubMed:24179220 |
| Chain | Residue | Details |
| F | ASN500 |
