5E4R
Crystal structure of domain-duplicated synthetic class II ketol-acid reductoisomerase 2Ia_KARI-DD
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 35 |
| Details | binding site for residue NAP A 501 |
| Chain | Residue |
| A | GLY24 |
| A | PRO82 |
| A | ASP83 |
| A | VAL85 |
| A | GLN86 |
| A | ALA107 |
| A | HIS108 |
| A | SER132 |
| A | PRO133 |
| A | GLY134 |
| A | ALA397 |
| A | TYR25 |
| A | VAL398 |
| A | SER399 |
| A | 40E504 |
| A | EDO505 |
| A | HOH613 |
| A | HOH641 |
| A | HOH670 |
| A | HOH672 |
| A | HOH686 |
| A | HOH704 |
| A | GLY26 |
| A | HOH709 |
| A | HOH712 |
| A | HOH728 |
| A | HOH751 |
| A | HOH775 |
| A | HOH802 |
| A | SER27 |
| A | GLN28 |
| A | LEU47 |
| A | SER53 |
| A | LEU80 |
| A | VAL81 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 502 |
| Chain | Residue |
| A | ASP191 |
| A | GLU195 |
| A | MG503 |
| A | 40E504 |
| A | HOH683 |
| A | HOH775 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue MG A 503 |
| Chain | Residue |
| A | ASP191 |
| A | MG502 |
| A | 40E504 |
| A | HOH601 |
| A | HOH627 |
| A | HOH638 |
| A | HOH675 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | binding site for residue 40E A 504 |
| Chain | Residue |
| A | PRO133 |
| A | ASP191 |
| A | GLU195 |
| A | GLU378 |
| A | VAL398 |
| A | SER399 |
| A | ALA402 |
| A | NAP501 |
| A | MG502 |
| A | MG503 |
| A | HOH601 |
| A | HOH638 |
| A | HOH675 |
| A | HOH683 |
| A | HOH775 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for residue EDO A 505 |
| Chain | Residue |
| A | LEU23 |
| A | GLY46 |
| A | LEU47 |
| A | GLU48 |
| A | THR67 |
| A | VAL81 |
| A | LEU89 |
| A | NAP501 |
| A | HOH728 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 506 |
| Chain | Residue |
| A | ASP7 |
| A | LEU12 |
| A | LYS170 |
| A | ARG176 |
| A | HOH676 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 180 |
| Details | Domain: {"description":"KARI N-terminal Rossmann","evidences":[{"source":"PROSITE-ProRule","id":"PRU01197","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 145 |
| Details | Domain: {"description":"KARI C-terminal knotted","evidences":[{"source":"PROSITE-ProRule","id":"PRU01198","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00435","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00435","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25849365","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4XDZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E4R","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25849365","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4XDZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E4R","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00435","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00435","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25849365","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
