5E2Q
Structure of human DPP3 in complex with angiotensin-II
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004177 | molecular_function | aminopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008235 | molecular_function | metalloexopeptidase activity |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008239 | molecular_function | dipeptidyl-peptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 801 |
| Chain | Residue |
| A | GLY162 |
| A | GLY164 |
| A | GLY167 |
| A | HOH958 |
| A | HOH1028 |
| A | HOH1037 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue K A 802 |
| Chain | Residue |
| A | SER504 |
| A | SER317 |
| A | GLY323 |
| A | ASP496 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"UniProtKB","id":"O55096","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22493238","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3FVY","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 7 |
| Details | Peptide: {"description":"Angiotensin-2","featureId":"PRO_0000032458","evidences":[{"source":"PubMed","id":"11815627","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9492317","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Peptide: {"description":"Angiotensin 1-7","featureId":"PRO_0000420660","evidences":[{"source":"PubMed","id":"15283675","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Peptide: {"description":"Angiotensin 1-5","featureId":"PRO_0000420661","evidences":[{"source":"PubMed","id":"10969042","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"11815627","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | Peptide: {"description":"Angiotensin 1-4","featureId":"PRO_0000420662","evidences":[{"source":"PubMed","id":"10969042","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"11815627","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | Peptide: {"description":"Angiotensin-3","featureId":"PRO_0000032459","evidences":[{"source":"PubMed","id":"10969042","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"1132082","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"11815627","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 5 |
| Details | Peptide: {"description":"Angiotensin-4","featureId":"PRO_0000420663","evidences":[{"source":"PubMed","id":"10969042","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"11815627","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Beta-decarboxylated aspartate; in form angiotensin-A","evidences":[{"source":"PubMed","id":"17138938","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
