Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5E0K

X-ray crystal structure of tryptophan synthase complex from Pyrococcus furiosus at 2.76 A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000162	biological_process	L-tryptophan biosynthetic process
A	0004834	molecular_function	tryptophan synthase activity
A	0005829	cellular_component	cytosol
A	0006568	biological_process	L-tryptophan metabolic process
A	0008652	biological_process	amino acid biosynthetic process
A	0009073	biological_process	aromatic amino acid family biosynthetic process
A	0016829	molecular_function	lyase activity
B	0000162	biological_process	L-tryptophan biosynthetic process
B	0004834	molecular_function	tryptophan synthase activity
B	0005737	cellular_component	cytoplasm
B	0006568	biological_process	L-tryptophan metabolic process
B	0008652	biological_process	amino acid biosynthetic process
B	0009073	biological_process	aromatic amino acid family biosynthetic process
B	0016829	molecular_function	lyase activity
C	0000162	biological_process	L-tryptophan biosynthetic process
C	0004834	molecular_function	tryptophan synthase activity
C	0005829	cellular_component	cytosol
C	0006568	biological_process	L-tryptophan metabolic process
C	0008652	biological_process	amino acid biosynthetic process
C	0009073	biological_process	aromatic amino acid family biosynthetic process
C	0016829	molecular_function	lyase activity
D	0000162	biological_process	L-tryptophan biosynthetic process
D	0004834	molecular_function	tryptophan synthase activity
D	0005737	cellular_component	cytoplasm
D	0006568	biological_process	L-tryptophan metabolic process
D	0008652	biological_process	amino acid biosynthetic process
D	0009073	biological_process	aromatic amino acid family biosynthetic process
D	0016829	molecular_function	lyase activity
E	0000162	biological_process	L-tryptophan biosynthetic process
E	0004834	molecular_function	tryptophan synthase activity
E	0005829	cellular_component	cytosol
E	0006568	biological_process	L-tryptophan metabolic process
E	0008652	biological_process	amino acid biosynthetic process
E	0009073	biological_process	aromatic amino acid family biosynthetic process
E	0016829	molecular_function	lyase activity
F	0000162	biological_process	L-tryptophan biosynthetic process
F	0004834	molecular_function	tryptophan synthase activity
F	0005737	cellular_component	cytoplasm
F	0006568	biological_process	L-tryptophan metabolic process
F	0008652	biological_process	amino acid biosynthetic process
F	0009073	biological_process	aromatic amino acid family biosynthetic process
F	0016829	molecular_function	lyase activity
G	0000162	biological_process	L-tryptophan biosynthetic process
G	0004834	molecular_function	tryptophan synthase activity
G	0005829	cellular_component	cytosol
G	0006568	biological_process	L-tryptophan metabolic process
G	0008652	biological_process	amino acid biosynthetic process
G	0009073	biological_process	aromatic amino acid family biosynthetic process
G	0016829	molecular_function	lyase activity
H	0000162	biological_process	L-tryptophan biosynthetic process
H	0004834	molecular_function	tryptophan synthase activity
H	0005737	cellular_component	cytoplasm
H	0006568	biological_process	L-tryptophan metabolic process
H	0008652	biological_process	amino acid biosynthetic process
H	0009073	biological_process	aromatic amino acid family biosynthetic process
H	0016829	molecular_function	lyase activity
I	0000162	biological_process	L-tryptophan biosynthetic process
I	0004834	molecular_function	tryptophan synthase activity
I	0005829	cellular_component	cytosol
I	0006568	biological_process	L-tryptophan metabolic process
I	0008652	biological_process	amino acid biosynthetic process
I	0009073	biological_process	aromatic amino acid family biosynthetic process
I	0016829	molecular_function	lyase activity
J	0000162	biological_process	L-tryptophan biosynthetic process
J	0004834	molecular_function	tryptophan synthase activity
J	0005737	cellular_component	cytoplasm
J	0006568	biological_process	L-tryptophan metabolic process
J	0008652	biological_process	amino acid biosynthetic process
J	0009073	biological_process	aromatic amino acid family biosynthetic process
J	0016829	molecular_function	lyase activity
K	0000162	biological_process	L-tryptophan biosynthetic process
K	0004834	molecular_function	tryptophan synthase activity
K	0005829	cellular_component	cytosol
K	0006568	biological_process	L-tryptophan metabolic process
K	0008652	biological_process	amino acid biosynthetic process
K	0009073	biological_process	aromatic amino acid family biosynthetic process
K	0016829	molecular_function	lyase activity
L	0000162	biological_process	L-tryptophan biosynthetic process
L	0004834	molecular_function	tryptophan synthase activity
L	0005737	cellular_component	cytoplasm
L	0006568	biological_process	L-tryptophan metabolic process
L	0008652	biological_process	amino acid biosynthetic process
L	0009073	biological_process	aromatic amino acid family biosynthetic process
L	0016829	molecular_function	lyase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue PO4 B 401

Chain	Residue
B	THR105
B	GLY106
B	ALA107
B	GLY108
B	GLN109
B	HIS110

site_id	AC2
Number of Residues	6
Details	binding site for residue PO4 D 401

Chain	Residue
D	GLY108
D	GLN109
D	HIS110
D	THR105
D	GLY106
D	ALA107

site_id	AC3
Number of Residues	6
Details	binding site for residue PO4 F 401

Chain	Residue
F	THR105
F	GLY106
F	ALA107
F	GLY108
F	GLN109
F	HIS110

site_id	AC4
Number of Residues	5
Details	binding site for residue PO4 H 401

Chain	Residue
H	THR105
H	GLY106
H	ALA107
H	GLN109
H	HIS110

site_id	AC5
Number of Residues	7
Details	binding site for residue PO4 J 401

Chain	Residue
J	LLP82
J	THR105
J	GLY106
J	ALA107
J	GLY108
J	GLN109
J	HIS110

site_id	AC6
Number of Residues	6
Details	binding site for residue PO4 L 401

Chain	Residue
L	THR105
L	GLY106
L	ALA107
L	GLY108
L	GLN109
L	HIS110

Functional Information from PROSITE/UniProt

site_id	PS00167
Number of Residues	14
Details	TRP_SYNTHASE_ALPHA Tryptophan synthase alpha chain signature. IELGiPFSDPIADG

Chain	Residue	Details
A	ILE35-GLY48

site_id	PS00168
Number of Residues	15
Details	TRP_SYNTHASE_BETA Tryptophan synthase beta chain pyridoxal-phosphate attachment site. LvHgGAHKtNnaIgQ

Chain	Residue	Details
B	LEU75-GLN89

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Active site: {"description":"Proton acceptor"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	6
Details	Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)