5DXA
Crystal structure of CARM1, sinefungin, and methylated PABP1 peptide (R460)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| A | 0018216 | biological_process | peptidyl-arginine methylation |
| B | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| B | 0018216 | biological_process | peptidyl-arginine methylation |
| C | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| C | 0018216 | biological_process | peptidyl-arginine methylation |
| D | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| D | 0018216 | biological_process | peptidyl-arginine methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | binding site for residue SFG A 501 |
| Chain | Residue |
| A | TYR149 |
| A | LEU198 |
| A | GLU214 |
| A | ALA215 |
| A | GLY240 |
| A | LYS241 |
| A | VAL242 |
| A | GLU243 |
| A | GLU257 |
| A | MET268 |
| A | SER271 |
| A | PHE150 |
| A | HOH619 |
| A | HOH620 |
| A | HOH643 |
| A | HOH645 |
| F | NMM12 |
| A | TYR153 |
| A | GLN159 |
| A | MET162 |
| A | ARG168 |
| A | GLY192 |
| A | CYS193 |
| A | ILE197 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 502 |
| Chain | Residue |
| A | ASP392 |
| A | HOH617 |
| A | HOH628 |
| site_id | AC3 |
| Number of Residues | 24 |
| Details | binding site for residue SFG B 501 |
| Chain | Residue |
| B | TYR149 |
| B | PHE150 |
| B | TYR153 |
| B | GLN159 |
| B | MET162 |
| B | ARG168 |
| B | GLY192 |
| B | CYS193 |
| B | ILE197 |
| B | LEU198 |
| B | GLU214 |
| B | ALA215 |
| B | GLY240 |
| B | LYS241 |
| B | VAL242 |
| B | GLU243 |
| B | GLU257 |
| B | MET268 |
| B | SER271 |
| B | HOH602 |
| B | HOH617 |
| B | HOH631 |
| B | HOH653 |
| G | NMM12 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 502 |
| Chain | Residue |
| B | ASP392 |
| B | HOH605 |
| B | HOH680 |
| site_id | AC5 |
| Number of Residues | 24 |
| Details | binding site for residue SFG C 501 |
| Chain | Residue |
| C | TYR149 |
| C | PHE150 |
| C | TYR153 |
| C | GLN159 |
| C | MET162 |
| C | ARG168 |
| C | GLY192 |
| C | CYS193 |
| C | GLY194 |
| C | ILE197 |
| C | LEU198 |
| C | GLU214 |
| C | ALA215 |
| C | GLY240 |
| C | LYS241 |
| C | VAL242 |
| C | GLU243 |
| C | GLU257 |
| C | MET268 |
| C | SER271 |
| C | HOH623 |
| C | HOH632 |
| C | HOH637 |
| C | HOH666 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | binding site for residue GOL C 502 |
| Chain | Residue |
| C | TRP403 |
| site_id | AC7 |
| Number of Residues | 25 |
| Details | binding site for residue SFG D 501 |
| Chain | Residue |
| D | HOH606 |
| D | HOH622 |
| D | HOH642 |
| D | HOH676 |
| I | NMM12 |
| D | TYR149 |
| D | PHE150 |
| D | TYR153 |
| D | GLN159 |
| D | MET162 |
| D | ARG168 |
| D | GLY192 |
| D | CYS193 |
| D | GLY194 |
| D | ILE197 |
| D | LEU198 |
| D | GLU214 |
| D | ALA215 |
| D | GLY240 |
| D | LYS241 |
| D | VAL242 |
| D | GLU243 |
| D | GLU257 |
| D | MET268 |
| D | SER271 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1228 |
| Details | Domain: {"description":"SAM-dependent MTase PRMT-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01015","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 132 |
| Details | Region: {"description":"Required for nuclear translocation","evidences":[{"source":"UniProtKB","id":"Q9WVG6","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21410432","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19843527","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"34480022","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Omega-N-methylated arginine; by CARM1; partial","evidences":[{"source":"PubMed","id":"11850402","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
