5DO9

Structure of regulator of G protein signaling 8 (RGS8) in complex with AlF4-activated Galpha-q

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001664	molecular_function	G protein-coupled receptor binding
A	0003924	molecular_function	GTPase activity
A	0007165	biological_process	signal transduction
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0019001	molecular_function	guanyl nucleotide binding
A	0031683	molecular_function	G-protein beta/gamma-subunit complex binding
C	0001664	molecular_function	G protein-coupled receptor binding
C	0003924	molecular_function	GTPase activity
C	0007165	biological_process	signal transduction
C	0007186	biological_process	G protein-coupled receptor signaling pathway
C	0019001	molecular_function	guanyl nucleotide binding
C	0031683	molecular_function	G-protein beta/gamma-subunit complex binding
E	0001664	molecular_function	G protein-coupled receptor binding
E	0003924	molecular_function	GTPase activity
E	0007165	biological_process	signal transduction
E	0007186	biological_process	G protein-coupled receptor signaling pathway
E	0019001	molecular_function	guanyl nucleotide binding
E	0031683	molecular_function	G-protein beta/gamma-subunit complex binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	24
Details	binding site for residue GDP A 401

Chain	Residue
A	GLU49
A	VAL182
A	ARG183
A	ASN274
A	LYS275
A	ASP277
A	LEU278
A	CYS330
A	ALA331
A	THR332
A	ALF402
A	SER50
A	MG403
A	HOH505
A	HOH508
A	HOH509
A	HOH512
A	GLY51
A	LYS52
A	SER53
A	THR54
A	SER156
A	LEU180
A	ARG181

---

site_id	AC2
Number of Residues	13
Details	binding site for residue ALF A 402

Chain	Residue
A	GLY48
A	GLU49
A	LYS52
A	ARG183
A	PRO185
A	THR186
A	GLY208
A	GLN209
A	GDP401
A	MG403
A	HOH509
A	HOH512
A	HOH525

---

site_id	AC3
Number of Residues	6
Details	binding site for residue MG A 403

Chain	Residue
A	SER53
A	THR186
A	GDP401
A	ALF402
A	HOH509
A	HOH512

---

site_id	AC4
Number of Residues	24
Details	binding site for residue GDP C 401

Chain	Residue
C	GLU49
C	SER50
C	GLY51
C	LYS52
C	SER53
C	THR54
C	LEU180
C	ARG181
C	VAL182
C	ARG183
C	ASN274
C	LYS275
C	ASP277
C	LEU278
C	CYS330
C	ALA331
C	THR332
C	ALF402
C	MG403
C	HOH502
C	HOH505
C	HOH508
C	HOH511
C	HOH512

---

site_id	AC5
Number of Residues	14
Details	binding site for residue ALF C 402

Chain	Residue
C	GLY48
C	GLU49
C	LYS52
C	ARG183
C	PRO185
C	THR186
C	VAL206
C	GLY208
C	GLN209
C	GDP401
C	MG403
C	HOH502
C	HOH505
C	HOH517

---

site_id	AC6
Number of Residues	6
Details	binding site for residue MG C 403

Chain	Residue
C	SER53
C	THR186
C	GDP401
C	ALF402
C	HOH502
C	HOH505

---

site_id	AC7
Number of Residues	25
Details	binding site for residue GDP E 401

Chain	Residue
E	LYS275
E	ASP277
E	LEU278
E	CYS330
E	ALA331
E	THR332
E	ALF402
E	MG403
E	HOH504
E	HOH506
E	HOH507
E	HOH509
E	HOH512
E	GLU49
E	SER50
E	GLY51
E	LYS52
E	SER53
E	THR54
E	SER156
E	LEU180
E	ARG181
E	VAL182
E	ARG183
E	ASN274

---

site_id	AC8
Number of Residues	14
Details	binding site for residue ALF E 402

Chain	Residue
E	GLY48
E	GLU49
E	LYS52
E	ARG183
E	PRO185
E	THR186
E	VAL206
E	GLY208
E	GLN209
E	GDP401
E	MG403
E	HOH504
E	HOH512
E	HOH555

---

site_id	AC9
Number of Residues	6
Details	binding site for residue MG E 403

Chain	Residue
E	SER53
E	THR186
E	GDP401
E	ALF402
E	HOH504
E	HOH512

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	BINDING: BINDING => ECO:0000305|PubMed:20966218, ECO:0007744|PDB:7SQ2

Chain	Residue	Details
A	SER50
A	LYS275
A	ASP277
A	ALA331
C	SER50
C	GLY51
C	LYS52
C	THR54
C	SER156
C	LEU180
C	ARG181
A	GLY51
C	ARG183
C	ASN274
C	LYS275
C	ASP277
C	ALA331
E	SER50
E	GLY51
E	LYS52
E	THR54
E	SER156
A	LYS52
E	LEU180
E	ARG181
E	ARG183
E	ASN274
E	LYS275
E	ASP277
E	ALA331
A	THR54
A	SER156
A	LEU180
A	ARG181
A	ARG183
A	ASN274

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:20966218, ECO:0007744|PDB:7SQ2

Chain	Residue	Details
A	SER53
A	THR186
C	SER53
C	THR186
E	SER53
E	THR186

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: 5-glutamyl histamine => ECO:0000269|PubMed:23022564

Chain	Residue	Details
A	GLN209
C	GLN209
E	GLN209

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