5DBX
Crystal structure of murine SPAK(T243D) in complex with AMPPNP
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue ANP A 401 |
| Chain | Residue |
| A | GLY84 |
| A | LEU211 |
| A | MG402 |
| A | HOH502 |
| A | HOH510 |
| A | ALA85 |
| A | THR86 |
| A | ALA87 |
| A | VAL89 |
| A | LYS104 |
| A | MET150 |
| A | LYS151 |
| A | LEU153 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | binding site for residue MG A 402 |
| Chain | Residue |
| A | ANP401 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue ANP B 401 |
| Chain | Residue |
| B | ILE81 |
| B | GLY84 |
| B | ALA85 |
| B | ALA87 |
| B | VAL89 |
| B | LYS104 |
| B | LYS151 |
| B | LEU153 |
| B | MG402 |
| B | HOH502 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue MG B 402 |
| Chain | Residue |
| B | ASN209 |
| B | ANP401 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGSGATAVVQaAlckprqer..........VAIK |
| Chain | Residue | Details |
| A | ILE81-LYS104 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine; by WNK4","evidences":[{"source":"PubMed","id":"16382158","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16530727","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21486947","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"16382158","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC/PRKCQ","evidences":[{"source":"UniProtKB","id":"Q9UEW8","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
