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5D80

Crystal Structure of Yeast V1-ATPase in the Autoinhibited Form

Functional Information from GO Data
ChainGOidnamespacecontents
a0005524molecular_functionATP binding
a0016887molecular_functionATP hydrolysis activity
a0033180cellular_componentproton-transporting V-type ATPase, V1 domain
a0046034biological_processATP metabolic process
a0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
a1902600biological_processproton transmembrane transport
A0005524molecular_functionATP binding
A0016887molecular_functionATP hydrolysis activity
A0033180cellular_componentproton-transporting V-type ATPase, V1 domain
A0046034biological_processATP metabolic process
A0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
A1902600biological_processproton transmembrane transport
b0005524molecular_functionATP binding
b0016887molecular_functionATP hydrolysis activity
b0033180cellular_componentproton-transporting V-type ATPase, V1 domain
b0046034biological_processATP metabolic process
b0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
b1902600biological_processproton transmembrane transport
B0005524molecular_functionATP binding
B0016887molecular_functionATP hydrolysis activity
B0033180cellular_componentproton-transporting V-type ATPase, V1 domain
B0046034biological_processATP metabolic process
B0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
B1902600biological_processproton transmembrane transport
c0005524molecular_functionATP binding
c0016887molecular_functionATP hydrolysis activity
c0033180cellular_componentproton-transporting V-type ATPase, V1 domain
c0046034biological_processATP metabolic process
c0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
c1902600biological_processproton transmembrane transport
C0005524molecular_functionATP binding
C0016887molecular_functionATP hydrolysis activity
C0033180cellular_componentproton-transporting V-type ATPase, V1 domain
C0046034biological_processATP metabolic process
C0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
C1902600biological_processproton transmembrane transport
d0000139cellular_componentGolgi membrane
d0000166molecular_functionnucleotide binding
d0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
d0000329cellular_componentfungal-type vacuole membrane
d0000425biological_processpexophagy
d0005515molecular_functionprotein binding
d0005524molecular_functionATP binding
d0005737cellular_componentcytoplasm
d0005774cellular_componentvacuolar membrane
d0005886cellular_componentplasma membrane
d0006811biological_processmonoatomic ion transport
d0006874biological_processintracellular calcium ion homeostasis
d0007035biological_processvacuolar acidification
d0010494cellular_componentcytoplasmic stress granule
d0033180cellular_componentproton-transporting V-type ATPase, V1 domain
d0045121cellular_componentmembrane raft
d0046034biological_processATP metabolic process
d0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
d0048388biological_processendosomal lumen acidification
d0055085biological_processtransmembrane transport
d0061795biological_processGolgi lumen acidification
d1902600biological_processproton transmembrane transport
d1902906biological_processproteasome storage granule assembly
d1990816cellular_componentvacuole-mitochondrion membrane contact site
D0000139cellular_componentGolgi membrane
D0000166molecular_functionnucleotide binding
D0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
D0000329cellular_componentfungal-type vacuole membrane
D0000425biological_processpexophagy
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005737cellular_componentcytoplasm
D0005774cellular_componentvacuolar membrane
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006874biological_processintracellular calcium ion homeostasis
D0007035biological_processvacuolar acidification
D0010494cellular_componentcytoplasmic stress granule
D0033180cellular_componentproton-transporting V-type ATPase, V1 domain
D0045121cellular_componentmembrane raft
D0046034biological_processATP metabolic process
D0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
D0048388biological_processendosomal lumen acidification
D0055085biological_processtransmembrane transport
D0061795biological_processGolgi lumen acidification
D1902600biological_processproton transmembrane transport
D1902906biological_processproteasome storage granule assembly
D1990816cellular_componentvacuole-mitochondrion membrane contact site
e0000139cellular_componentGolgi membrane
e0000166molecular_functionnucleotide binding
e0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
e0000329cellular_componentfungal-type vacuole membrane
e0000425biological_processpexophagy
e0005515molecular_functionprotein binding
e0005524molecular_functionATP binding
e0005737cellular_componentcytoplasm
e0005774cellular_componentvacuolar membrane
e0005886cellular_componentplasma membrane
e0006811biological_processmonoatomic ion transport
e0006874biological_processintracellular calcium ion homeostasis
e0007035biological_processvacuolar acidification
e0010494cellular_componentcytoplasmic stress granule
e0033180cellular_componentproton-transporting V-type ATPase, V1 domain
e0045121cellular_componentmembrane raft
e0046034biological_processATP metabolic process
e0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
e0048388biological_processendosomal lumen acidification
e0055085biological_processtransmembrane transport
e0061795biological_processGolgi lumen acidification
e1902600biological_processproton transmembrane transport
e1902906biological_processproteasome storage granule assembly
e1990816cellular_componentvacuole-mitochondrion membrane contact site
E0000139cellular_componentGolgi membrane
E0000166molecular_functionnucleotide binding
E0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
E0000329cellular_componentfungal-type vacuole membrane
E0000425biological_processpexophagy
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005737cellular_componentcytoplasm
E0005774cellular_componentvacuolar membrane
E0005886cellular_componentplasma membrane
E0006811biological_processmonoatomic ion transport
E0006874biological_processintracellular calcium ion homeostasis
E0007035biological_processvacuolar acidification
E0010494cellular_componentcytoplasmic stress granule
E0033180cellular_componentproton-transporting V-type ATPase, V1 domain
E0045121cellular_componentmembrane raft
E0046034biological_processATP metabolic process
E0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
E0048388biological_processendosomal lumen acidification
E0055085biological_processtransmembrane transport
E0061795biological_processGolgi lumen acidification
E1902600biological_processproton transmembrane transport
E1902906biological_processproteasome storage granule assembly
E1990816cellular_componentvacuole-mitochondrion membrane contact site
f0000139cellular_componentGolgi membrane
f0000166molecular_functionnucleotide binding
f0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
f0000329cellular_componentfungal-type vacuole membrane
f0000425biological_processpexophagy
f0005515molecular_functionprotein binding
f0005524molecular_functionATP binding
f0005737cellular_componentcytoplasm
f0005774cellular_componentvacuolar membrane
f0005886cellular_componentplasma membrane
f0006811biological_processmonoatomic ion transport
f0006874biological_processintracellular calcium ion homeostasis
f0007035biological_processvacuolar acidification
f0010494cellular_componentcytoplasmic stress granule
f0033180cellular_componentproton-transporting V-type ATPase, V1 domain
f0045121cellular_componentmembrane raft
f0046034biological_processATP metabolic process
f0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
f0048388biological_processendosomal lumen acidification
f0055085biological_processtransmembrane transport
f0061795biological_processGolgi lumen acidification
f1902600biological_processproton transmembrane transport
f1902906biological_processproteasome storage granule assembly
f1990816cellular_componentvacuole-mitochondrion membrane contact site
F0000139cellular_componentGolgi membrane
F0000166molecular_functionnucleotide binding
F0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
F0000329cellular_componentfungal-type vacuole membrane
F0000425biological_processpexophagy
F0005515molecular_functionprotein binding
F0005524molecular_functionATP binding
F0005737cellular_componentcytoplasm
F0005774cellular_componentvacuolar membrane
F0005886cellular_componentplasma membrane
F0006811biological_processmonoatomic ion transport
F0006874biological_processintracellular calcium ion homeostasis
F0007035biological_processvacuolar acidification
F0010494cellular_componentcytoplasmic stress granule
F0033180cellular_componentproton-transporting V-type ATPase, V1 domain
F0045121cellular_componentmembrane raft
F0046034biological_processATP metabolic process
F0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
F0048388biological_processendosomal lumen acidification
F0055085biological_processtransmembrane transport
F0061795biological_processGolgi lumen acidification
F1902600biological_processproton transmembrane transport
F1902906biological_processproteasome storage granule assembly
F1990816cellular_componentvacuole-mitochondrion membrane contact site
g0000139cellular_componentGolgi membrane
g0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
g0000329cellular_componentfungal-type vacuole membrane
g0005515molecular_functionprotein binding
g0005774cellular_componentvacuolar membrane
g0006811biological_processmonoatomic ion transport
g0007035biological_processvacuolar acidification
g0016471cellular_componentvacuolar proton-transporting V-type ATPase complex
g0045121cellular_componentmembrane raft
g0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
g0048388biological_processendosomal lumen acidification
g0061795biological_processGolgi lumen acidification
g1902600biological_processproton transmembrane transport
G0000139cellular_componentGolgi membrane
G0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
G0000329cellular_componentfungal-type vacuole membrane
G0005515molecular_functionprotein binding
G0005774cellular_componentvacuolar membrane
G0006811biological_processmonoatomic ion transport
G0007035biological_processvacuolar acidification
G0016471cellular_componentvacuolar proton-transporting V-type ATPase complex
G0045121cellular_componentmembrane raft
G0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
G0048388biological_processendosomal lumen acidification
G0061795biological_processGolgi lumen acidification
G1902600biological_processproton transmembrane transport
h0000139cellular_componentGolgi membrane
h0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
h0000329cellular_componentfungal-type vacuole membrane
h0005515molecular_functionprotein binding
h0005774cellular_componentvacuolar membrane
h0006811biological_processmonoatomic ion transport
h0007035biological_processvacuolar acidification
h0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
h0048388biological_processendosomal lumen acidification
h0061795biological_processGolgi lumen acidification
h1902600biological_processproton transmembrane transport
H0000139cellular_componentGolgi membrane
H0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
H0000329cellular_componentfungal-type vacuole membrane
H0005515molecular_functionprotein binding
H0005774cellular_componentvacuolar membrane
H0006811biological_processmonoatomic ion transport
H0007035biological_processvacuolar acidification
H0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
H0048388biological_processendosomal lumen acidification
H0061795biological_processGolgi lumen acidification
H1902600biological_processproton transmembrane transport
i0000139cellular_componentGolgi membrane
i0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
i0000329cellular_componentfungal-type vacuole membrane
i0005515molecular_functionprotein binding
i0005774cellular_componentvacuolar membrane
i0006811biological_processmonoatomic ion transport
i0007035biological_processvacuolar acidification
i0033178cellular_componentproton-transporting two-sector ATPase complex, catalytic domain
i0045121cellular_componentmembrane raft
i0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
i0048388biological_processendosomal lumen acidification
i0061795biological_processGolgi lumen acidification
i1902600biological_processproton transmembrane transport
I0000139cellular_componentGolgi membrane
I0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
I0000329cellular_componentfungal-type vacuole membrane
I0005515molecular_functionprotein binding
I0005774cellular_componentvacuolar membrane
I0006811biological_processmonoatomic ion transport
I0007035biological_processvacuolar acidification
I0033178cellular_componentproton-transporting two-sector ATPase complex, catalytic domain
I0045121cellular_componentmembrane raft
I0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
I0048388biological_processendosomal lumen acidification
I0061795biological_processGolgi lumen acidification
I1902600biological_processproton transmembrane transport
j0000139cellular_componentGolgi membrane
j0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
j0000329cellular_componentfungal-type vacuole membrane
j0005515molecular_functionprotein binding
j0005774cellular_componentvacuolar membrane
j0006811biological_processmonoatomic ion transport
j0007035biological_processvacuolar acidification
j0016471cellular_componentvacuolar proton-transporting V-type ATPase complex
j0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
j0048388biological_processendosomal lumen acidification
j0061795biological_processGolgi lumen acidification
j1902600biological_processproton transmembrane transport
J0000139cellular_componentGolgi membrane
J0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
J0000329cellular_componentfungal-type vacuole membrane
J0005515molecular_functionprotein binding
J0005774cellular_componentvacuolar membrane
J0006811biological_processmonoatomic ion transport
J0007035biological_processvacuolar acidification
J0016471cellular_componentvacuolar proton-transporting V-type ATPase complex
J0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
J0048388biological_processendosomal lumen acidification
J0061795biological_processGolgi lumen acidification
J1902600biological_processproton transmembrane transport
k0000139cellular_componentGolgi membrane
k0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
k0000329cellular_componentfungal-type vacuole membrane
k0005515molecular_functionprotein binding
k0005774cellular_componentvacuolar membrane
k0006811biological_processmonoatomic ion transport
k0007035biological_processvacuolar acidification
k0033178cellular_componentproton-transporting two-sector ATPase complex, catalytic domain
k0045121cellular_componentmembrane raft
k0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
k0048388biological_processendosomal lumen acidification
k0061795biological_processGolgi lumen acidification
k1902600biological_processproton transmembrane transport
K0000139cellular_componentGolgi membrane
K0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
K0000329cellular_componentfungal-type vacuole membrane
K0005515molecular_functionprotein binding
K0005774cellular_componentvacuolar membrane
K0006811biological_processmonoatomic ion transport
K0007035biological_processvacuolar acidification
K0033178cellular_componentproton-transporting two-sector ATPase complex, catalytic domain
K0045121cellular_componentmembrane raft
K0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
K0048388biological_processendosomal lumen acidification
K0061795biological_processGolgi lumen acidification
K1902600biological_processproton transmembrane transport
l0000139cellular_componentGolgi membrane
l0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
l0000329cellular_componentfungal-type vacuole membrane
l0005515molecular_functionprotein binding
l0005774cellular_componentvacuolar membrane
l0006811biological_processmonoatomic ion transport
l0007035biological_processvacuolar acidification
l0016471cellular_componentvacuolar proton-transporting V-type ATPase complex
l0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
l0048388biological_processendosomal lumen acidification
l0061795biological_processGolgi lumen acidification
l1902600biological_processproton transmembrane transport
L0000139cellular_componentGolgi membrane
L0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
L0000329cellular_componentfungal-type vacuole membrane
L0005515molecular_functionprotein binding
L0005774cellular_componentvacuolar membrane
L0006811biological_processmonoatomic ion transport
L0007035biological_processvacuolar acidification
L0016471cellular_componentvacuolar proton-transporting V-type ATPase complex
L0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
L0048388biological_processendosomal lumen acidification
L0061795biological_processGolgi lumen acidification
L1902600biological_processproton transmembrane transport
m0000139cellular_componentGolgi membrane
m0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
m0000329cellular_componentfungal-type vacuole membrane
m0005515molecular_functionprotein binding
m0005774cellular_componentvacuolar membrane
m0006811biological_processmonoatomic ion transport
m0007035biological_processvacuolar acidification
m0033178cellular_componentproton-transporting two-sector ATPase complex, catalytic domain
m0045121cellular_componentmembrane raft
m0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
m0048388biological_processendosomal lumen acidification
m0061795biological_processGolgi lumen acidification
m1902600biological_processproton transmembrane transport
M0000139cellular_componentGolgi membrane
M0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
M0000329cellular_componentfungal-type vacuole membrane
M0005515molecular_functionprotein binding
M0005774cellular_componentvacuolar membrane
M0006811biological_processmonoatomic ion transport
M0007035biological_processvacuolar acidification
M0033178cellular_componentproton-transporting two-sector ATPase complex, catalytic domain
M0045121cellular_componentmembrane raft
M0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
M0048388biological_processendosomal lumen acidification
M0061795biological_processGolgi lumen acidification
M1902600biological_processproton transmembrane transport
n0000139cellular_componentGolgi membrane
n0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
n0000329cellular_componentfungal-type vacuole membrane
n0005515molecular_functionprotein binding
n0005774cellular_componentvacuolar membrane
n0006811biological_processmonoatomic ion transport
n0007035biological_processvacuolar acidification
n0016471cellular_componentvacuolar proton-transporting V-type ATPase complex
n0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
n0048388biological_processendosomal lumen acidification
n0061795biological_processGolgi lumen acidification
n1902600biological_processproton transmembrane transport
N0000139cellular_componentGolgi membrane
N0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
N0000329cellular_componentfungal-type vacuole membrane
N0005515molecular_functionprotein binding
N0005774cellular_componentvacuolar membrane
N0006811biological_processmonoatomic ion transport
N0007035biological_processvacuolar acidification
N0016471cellular_componentvacuolar proton-transporting V-type ATPase complex
N0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
N0048388biological_processendosomal lumen acidification
N0061795biological_processGolgi lumen acidification
N1902600biological_processproton transmembrane transport
o0000139cellular_componentGolgi membrane
o0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
o0000329cellular_componentfungal-type vacuole membrane
o0005515molecular_functionprotein binding
o0005774cellular_componentvacuolar membrane
o0006811biological_processmonoatomic ion transport
o0007035biological_processvacuolar acidification
o0016020cellular_componentmembrane
o0033180cellular_componentproton-transporting V-type ATPase, V1 domain
o0034220biological_processmonoatomic ion transmembrane transport
o0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
o0048388biological_processendosomal lumen acidification
o0061795biological_processGolgi lumen acidification
o1902600biological_processproton transmembrane transport
O0000139cellular_componentGolgi membrane
O0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
O0000329cellular_componentfungal-type vacuole membrane
O0005515molecular_functionprotein binding
O0005774cellular_componentvacuolar membrane
O0006811biological_processmonoatomic ion transport
O0007035biological_processvacuolar acidification
O0016020cellular_componentmembrane
O0033180cellular_componentproton-transporting V-type ATPase, V1 domain
O0034220biological_processmonoatomic ion transmembrane transport
O0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
O0048388biological_processendosomal lumen acidification
O0061795biological_processGolgi lumen acidification
O1902600biological_processproton transmembrane transport
Functional Information from PROSITE/UniProt
site_idPS00152
Number of Residues10
DetailsATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature. PSINTSVSYS
ChainResidueDetails
APRO453-SER462
DPRO371-SER380

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues42
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P38606","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues6
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues12
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P21281","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues6
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues1
DetailsModified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues57
DetailsRegion: {"description":"Interaction with VMA10","evidences":[{"source":"PubMed","id":"15751969","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues60
DetailsCoiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

Catalytic Information from CSA
site_idMCSA1
Number of Residues1
DetailsM-CSA 508
ChainResidueDetails
ACYS284covalent catalysis

site_idMCSA2
Number of Residues1
DetailsM-CSA 508
ChainResidueDetails
BCYS284covalent catalysis

site_idMCSA3
Number of Residues1
DetailsM-CSA 508
ChainResidueDetails
CCYS284covalent catalysis

site_idMCSA4
Number of Residues1
DetailsM-CSA 508
ChainResidueDetails

site_idMCSA5
Number of Residues1
DetailsM-CSA 508
ChainResidueDetails

site_idMCSA6
Number of Residues1
DetailsM-CSA 508
ChainResidueDetails

249697

PDB entries from 2026-02-25

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