5D6F
Structure of human methionine aminopeptidase-2 complexed with spiroepoxytriazole inhibitor (+)-31b
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue 57R A 501 |
| Chain | Residue |
| A | HIS231 |
| A | HOH607 |
| A | HOH736 |
| A | HOH828 |
| A | HOH835 |
| A | ASN327 |
| A | LEU328 |
| A | ASN329 |
| A | ILE338 |
| A | HIS339 |
| A | GLU364 |
| A | ALA414 |
| A | TYR444 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue CO A 502 |
| Chain | Residue |
| A | ASP251 |
| A | ASP262 |
| A | GLU459 |
| A | HOH828 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue TBU A 503 |
| Chain | Residue |
| A | THR268 |
| A | PHE269 |
| A | ASN270 |
| A | ASP274 |
| A | HOH668 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue TBU A 504 |
| Chain | Residue |
| A | PRO189 |
| A | TYR244 |
| A | TYR244 |
| A | HOH702 |
| A | HOH702 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 505 |
| Chain | Residue |
| A | TYR336 |
| A | PHE410 |
| A | GLY411 |
| A | THR412 |
| A | HOH710 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 506 |
| Chain | Residue |
| A | GLY190 |
| A | THR192 |
| A | GLN243 |
| A | HOH604 |
| A | HOH637 |
| A | HOH730 |
Functional Information from PROSITE/UniProt
| site_id | PS01202 |
| Number of Residues | 17 |
| Details | MAP_2 Methionine aminopeptidase subfamily 2 signature. DIcKIDfGtHISGriiD |
| Chain | Residue | Details |
| A | ASP246-ASP262 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03175","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16540317","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03175","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14534293","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16134930","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16540317","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17350258","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17636946","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
