Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003916 | molecular_function | DNA topoisomerase activity |
| A | 0003917 | molecular_function | DNA topoisomerase type I (single strand cut, ATP-independent) activity |
| A | 0006265 | biological_process | DNA topological change |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 801 |
| Chain | Residue |
| A | ARG54 |
| A | ARG168 |
| A | ARG172 |
| A | HOH911 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 802 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 803 |
| Chain | Residue |
| A | VAL195 |
| A | GLN196 |
| A | HOH931 |
| A | ASP171 |
| A | GLY193 |
| A | ARG194 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 804 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 805 |
| Chain | Residue |
| A | ARG326 |
| A | SER329 |
| A | ARG333 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue GOL A 806 |
| Chain | Residue |
| A | HIS509 |
| A | ALA510 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 807 |
| Chain | Residue |
| A | PRO81 |
| A | TRP121 |
| A | ASP162 |
| A | GLU165 |
| A | ARG600 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue ACT A 808 |
| Chain | Residue |
| A | GLY112 |
| A | PHE138 |
| A | HIS139 |
| A | TYR342 |
| A | GLN386 |
| A | GLU387 |
| A | HIS389 |
Functional Information from PROSITE/UniProt
| site_id | PS00396 |
| Number of Residues | 15 |
| Details | TOPO_IA_1 Topoisomerase (Topo) IA-type active site signature. QrLYEngy.........ITYmRTD |
| Chain | Residue | Details |
| A | GLN332-ASP346 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 124 |
| Details | Domain: {"description":"Toprim","evidences":[{"source":"HAMAP-Rule","id":"MF_00952","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 459 |
| Details | Domain: {"description":"Topo IA-type catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU01383","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | Region: {"description":"Interaction with DNA","evidences":[{"source":"HAMAP-Rule","id":"MF_00952","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Active site: {"description":"O-(5'-phospho-DNA)-tyrosine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU01383","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00952","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Site: {"description":"Interaction with DNA","evidences":[{"source":"HAMAP-Rule","id":"MF_00952","evidenceCode":"ECO:0000255"}]} |
