5D46

Structural Basis for a New Templated Activity by Terminal Deoxynucleotidyl Transferase: Implications for V(D)J Recombination

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0006281	biological_process	DNA repair
A	0016779	molecular_function	nucleotidyltransferase activity
A	0034061	molecular_function	DNA polymerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue MG A 601

Chain	Residue
A	ASP343
A	ASP345
A	POP603
C	DC7

---

site_id	AC2
Number of Residues	4
Details	binding site for residue NA A 602

Chain	Residue
A	THR253
A	VAL255
A	VAL258
C	DT5

---

site_id	AC3
Number of Residues	10
Details	binding site for residue POP A 603

Chain	Residue
A	GLY333
A	ARG336
A	LYS338
A	GLY341
A	HIS342
A	ASP343
A	ASP345
A	MG601
C	DC7
A	GLY332

---

site_id	AC4
Number of Residues	4
Details	binding site for residue SO4 A 604

Chain	Residue
A	ASP298
A	GLY425
A	LYS426
A	TRP428

---

site_id	AC5
Number of Residues	1
Details	binding site for residue SO4 A 605

Chain	Residue
A	ARG480

---

site_id	AC6
Number of Residues	5
Details	binding site for residue ACT A 606

Chain	Residue
A	ASN184
A	GLY186
A	SER187
A	HOH704
A	HOH715

---

site_id	AC7
Number of Residues	3
Details	binding site for residue ACT A 607

Chain	Residue
A	LYS338
A	MET339
A	THR340

---

site_id	AC8
Number of Residues	1
Details	binding site for residue ACT A 608

Chain	Residue
A	GLY213

---

Functional Information from PROSITE/UniProt

site_id	PS00522
Number of Residues	20
Details	DNA_POLYMERASE_X DNA polymerase family X signature. GGFrRGkmtGhDVDFLItsP

Chain	Residue	Details
A	GLY332-PRO351

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000305, ECO:0007744|PDB:4I2B, ECO:0007744|PDB:4I2C, ECO:0007744|PDB:4I2D, ECO:0007744|PDB:4I2E

Chain	Residue	Details
A	GLY333
A	HIS342
A	GLY449

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000305, ECO:0007744|PDB:1JMS, ECO:0007744|PDB:4I2B

Chain	Residue	Details
A	ASP343
A	ASP345
A	ASP434

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079

Chain	Residue	Details
A	SER134

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	3
Details	M-CSA 632

Chain	Residue	Details
A	ASP343	metal ligand
A	ASP345	metal ligand
A	ASP434	metal ligand, proton acceptor, proton donor

---