5D0R

Crystal structure of human soluble Adenylyl Cyclase with the inhibitor bithionol

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0009190	biological_process	cyclic nucleotide biosynthetic process
A	0035556	biological_process	intracellular signal transduction

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue B1T A 501

Chain	Residue
A	PHE45
A	MET337
A	PHE338
A	ACT502
A	LYS95
A	ALA97
A	ALA100
A	LEU102
A	VAL172
A	VAL175
A	ARG176
A	PHE336

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ACT A 502

Chain	Residue
A	PHE338
A	ASN412
A	B1T501
A	HOH682

---

site_id	AC3
Number of Residues	4
Details	binding site for residue EDO A 503

Chain	Residue
A	SER80
A	HIS398
A	THR399
A	HOH640

---

site_id	AC4
Number of Residues	4
Details	binding site for residue EDO A 504

Chain	Residue
A	THR55
A	ILE390
A	PHE392
A	GLN409

---

site_id	AC5
Number of Residues	3
Details	binding site for residue EDO A 505

Chain	Residue
A	HIS162
A	LYS267
A	TYR268

---

site_id	AC6
Number of Residues	7
Details	binding site for residue EDO A 506

Chain	Residue
A	PHE39
A	ASP40
A	ARG106
A	VAL107
A	GLU108
A	LYS468
A	HOH622

---

site_id	AC7
Number of Residues	7
Details	binding site for residue EDO A 507

Chain	Residue
A	TRP194
A	ARG199
A	ILE202
A	GLU203
A	ILE204
A	ILE327
A	HOH609

---

site_id	AC8
Number of Residues	5
Details	binding site for residue EDO A 508

Chain	Residue
A	TYR240
A	PRO241
A	LYS246
A	HOH638
A	HOH677

---

site_id	AC9
Number of Residues	4
Details	binding site for residue DMS A 509

Chain	Residue
A	TYR77
A	HIS78
A	LEU129
A	GLN133

---

site_id	AD1
Number of Residues	7
Details	binding site for residue DMS A 510

Chain	Residue
A	ILE24
A	GLY27
A	HIS28
A	PHE29
A	SER264
A	TYR268
A	HOH753

---

site_id	AD2
Number of Residues	4
Details	binding site for residue DMS A 511

Chain	Residue
A	THR322
A	GLN331
A	ILE332
A	HOH673

---

site_id	AD3
Number of Residues	8
Details	binding site for residue GOL A 512

Chain	Residue
A	MET64
A	THR161
A	HIS162
A	GLN266
A	LYS267
A	VAL269
A	GLU271
A	HOH603

---

site_id	AD4
Number of Residues	6
Details	binding site for residue GOL A 513

Chain	Residue
A	ASP22
A	LEU23
A	ASP92
A	LEU104
A	ARG106
A	TYR239

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	137
Details	Domain: {"description":"Guanylate cyclase 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00099","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25040695","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24567411","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24616449","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4USW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00099","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24567411","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24616449","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4CLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OYZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24567411","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24616449","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25040695","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---