5CM9

Structural Basis for the Selectivity of Guanine Nucleotide Exchange Factors for the small G-protein Ral

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005085	molecular_function	guanyl-nucleotide exchange factor activity
A	0007264	biological_process	small GTPase-mediated signal transduction
B	0005085	molecular_function	guanyl-nucleotide exchange factor activity
B	0007264	biological_process	small GTPase-mediated signal transduction
C	0003924	molecular_function	GTPase activity
C	0003925	molecular_function	G protein activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005886	cellular_component	plasma membrane
C	0007165	biological_process	signal transduction
C	0007265	biological_process	Ras protein signal transduction
C	0007298	biological_process	border follicle cell migration
C	0007464	biological_process	R3/R4 cell fate commitment
C	0016020	cellular_component	membrane
C	0016787	molecular_function	hydrolase activity
C	0019003	molecular_function	GDP binding
C	0022604	biological_process	regulation of cell morphogenesis
C	0030165	molecular_function	PDZ domain binding
C	0031623	biological_process	receptor internalization
C	0032154	cellular_component	cleavage furrow
C	0045087	biological_process	innate immune response
C	0045742	biological_process	positive regulation of epidermal growth factor receptor signaling pathway
C	0045824	biological_process	negative regulation of innate immune response
C	0046329	biological_process	negative regulation of JNK cascade
C	0050829	biological_process	defense response to Gram-negative bacterium
C	0090543	cellular_component	Flemming body
C	2000648	biological_process	positive regulation of stem cell proliferation
D	0003924	molecular_function	GTPase activity
D	0003925	molecular_function	G protein activity
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005886	cellular_component	plasma membrane
D	0007165	biological_process	signal transduction
D	0007265	biological_process	Ras protein signal transduction
D	0007298	biological_process	border follicle cell migration
D	0007464	biological_process	R3/R4 cell fate commitment
D	0016020	cellular_component	membrane
D	0016787	molecular_function	hydrolase activity
D	0019003	molecular_function	GDP binding
D	0022604	biological_process	regulation of cell morphogenesis
D	0030165	molecular_function	PDZ domain binding
D	0031623	biological_process	receptor internalization
D	0032154	cellular_component	cleavage furrow
D	0045087	biological_process	innate immune response
D	0045742	biological_process	positive regulation of epidermal growth factor receptor signaling pathway
D	0045824	biological_process	negative regulation of innate immune response
D	0046329	biological_process	negative regulation of JNK cascade
D	0050829	biological_process	defense response to Gram-negative bacterium
D	0090543	cellular_component	Flemming body
D	2000648	biological_process	positive regulation of stem cell proliferation

Functional Information from PROSITE/UniProt

site_id	PS00720
Number of Residues	31
Details	RASGEF Ras Guanine-nucleotide exchange factors domain signature. VPYlGtfLkDLvmldaaskdelengy....................INFdK

Chain	Residue	Details
A	VAL429-LYS459

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
C	GLY18
C	ASP65
C	ASN124
D	GLY18
D	ASP65
D	ASN124

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Cysteine methyl ester => ECO:0000250

Chain	Residue	Details
C	CYS198
D	CYS198

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site_id	SWS_FT_FI3
Number of Residues	2
Details	LIPID: S-geranylgeranyl cysteine => ECO:0000250

Chain	Residue	Details
C	CYS198
D	CYS198

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