5C8W

PKG II's Amino Terminal Cyclic Nucleotide Binding Domain (CNB-A) in a complex with cGMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005952	cellular_component	cAMP-dependent protein kinase complex
B	0005952	cellular_component	cAMP-dependent protein kinase complex
C	0005952	cellular_component	cAMP-dependent protein kinase complex
D	0005952	cellular_component	cAMP-dependent protein kinase complex
E	0005952	cellular_component	cAMP-dependent protein kinase complex
F	0005952	cellular_component	cAMP-dependent protein kinase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue MLA A 301

Chain	Residue
A	ARG187
A	HOH512
A	ILE195
A	PRO201
A	ASN203
A	HIS204
A	ARG242
A	HOH418
A	HOH432
A	HOH439

---

site_id	AC2
Number of Residues	18
Details	binding site for residue PCG A 302

Chain	Residue
A	VAL215
A	LEU222
A	SER223
A	PHE231
A	GLY232
A	GLU233
A	LEU234
A	ALA235
A	ARG242
A	THR243
A	ALA244
A	VAL246
A	HOH460
A	HOH476
A	HOH500
B	CYS240
B	THR243
B	HOH450

---

site_id	AC3
Number of Residues	2
Details	binding site for residue NA A 303

Chain	Residue
A	GLN198
B	GLN198

---

site_id	AC4
Number of Residues	7
Details	binding site for residue MLA B 301

Chain	Residue
B	ILE195
B	PRO201
B	ASN203
B	HIS204
B	ARG242
B	HOH411
B	HOH416

---

site_id	AC5
Number of Residues	5
Details	binding site for residue MLA B 302

Chain	Residue
B	ALA147
B	TYR185
B	ASP258
D	TYR185
D	ASP258

---

site_id	AC6
Number of Residues	16
Details	binding site for residue PCG B 303

Chain	Residue
A	CYS240
A	THR243
B	SER223
B	PHE231
B	GLY232
B	GLU233
B	LEU234
B	ALA235
B	ARG242
B	THR243
B	ALA244
B	VAL246
B	HOH441
B	HOH443
B	HOH451
B	HOH489

---

site_id	AC7
Number of Residues	8
Details	binding site for residue MLA C 301

Chain	Residue
C	ILE195
C	ASN203
C	HIS204
C	ARG242
C	HOH401
C	HOH408
C	HOH423
C	HOH433

---

site_id	AC8
Number of Residues	16
Details	binding site for residue PCG C 302

Chain	Residue
C	VAL215
C	SER223
C	PHE231
C	GLY232
C	GLU233
C	LEU234
C	ALA235
C	ARG242
C	THR243
C	ALA244
C	HOH424
C	HOH458
C	HOH484
E	CYS240
E	THR243
E	HOH441

---

site_id	AC9
Number of Residues	2
Details	binding site for residue NA C 303

Chain	Residue
C	GLN198
E	GLN198

---

site_id	AD1
Number of Residues	6
Details	binding site for residue MLA D 301

Chain	Residue
D	ILE195
D	ASN203
D	HIS204
D	ARG242
D	HOH410
D	HOH411

---

site_id	AD2
Number of Residues	13
Details	binding site for residue PCG D 302

Chain	Residue
D	HOH457
F	THR243
F	HOH446
F	HOH451
D	SER223
D	PHE231
D	GLY232
D	GLU233
D	LEU234
D	ALA235
D	ARG242
D	THR243
D	ALA244

---

site_id	AD3
Number of Residues	6
Details	binding site for residue MLA E 301

Chain	Residue
E	ILE195
E	ASN203
E	HIS204
E	ARG242
E	HOH404
E	HOH417

---

site_id	AD4
Number of Residues	15
Details	binding site for residue PCG E 302

Chain	Residue
C	CYS240
C	THR243
C	HOH446
C	HOH447
E	VAL215
E	LEU222
E	SER223
E	GLY232
E	GLU233
E	LEU234
E	ALA235
E	ARG242
E	THR243
E	ALA244
E	HOH421

---

site_id	AD5
Number of Residues	6
Details	binding site for residue MLA F 301

Chain	Residue
F	ILE195
F	ASN203
F	HIS204
F	ARG242
F	HOH403
F	HOH409

---

site_id	AD6
Number of Residues	17
Details	binding site for residue PCG F 302

Chain	Residue
D	CYS240
D	THR243
D	HOH446
D	HOH453
F	LEU222
F	SER223
F	PHE231
F	GLY232
F	GLU233
F	LEU234
F	ALA235
F	ARG242
F	THR243
F	ALA244
F	HOH421
F	HOH425
F	HOH440

---

site_id	AD7
Number of Residues	2
Details	binding site for residue NA F 303

Chain	Residue
D	GLN198
F	GLN198

---

Functional Information from PROSITE/UniProt

site_id	PS00888
Number of Residues	17
Details	CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. IIkQGEpGNhIFVLaeG

Chain	Residue	Details
A	ILE195-GLY211

---

site_id	PS00889
Number of Residues	18
Details	CNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. FGElAIlynct......RTAsVkA

Chain	Residue	Details
A	PHE231-ALA248

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26769964","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5C8W","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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