Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5C6W

anti-CXCL13 scFv - E10

Functional Information from GO Data

Chain	GOid	namespace	contents
H	0002250	biological_process	adaptive immune response
H	0002376	biological_process	immune system process
H	0003823	molecular_function	antigen binding
H	0005576	cellular_component	extracellular region
H	0005886	cellular_component	plasma membrane
H	0006955	biological_process	immune response
H	0016064	biological_process	immunoglobulin mediated immune response
H	0019814	cellular_component	immunoglobulin complex
H	0070062	cellular_component	extracellular exosome
J	0002250	biological_process	adaptive immune response
J	0002376	biological_process	immune system process
J	0003823	molecular_function	antigen binding
J	0005576	cellular_component	extracellular region
J	0005886	cellular_component	plasma membrane
J	0006955	biological_process	immune response
J	0016064	biological_process	immunoglobulin mediated immune response
J	0019814	cellular_component	immunoglobulin complex
J	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue CL H 1202

Chain	Residue
H	LYS23
H	EDO1208

site_id	AC2
Number of Residues	1
Details	binding site for residue CL H 1203

Chain	Residue
H	GLY8

site_id	AC3
Number of Residues	2
Details	binding site for residue CL H 1204

Chain	Residue
H	HIS1062
H	EDO1207

site_id	AC4
Number of Residues	9
Details	binding site for residue SO4 H 1205

Chain	Residue
H	HOH1366
J	THR28
J	PHE29
J	TYR32
J	HOH1303
H	THR28
H	PHE29
H	TYR32
H	HOH1304

site_id	AC5
Number of Residues	3
Details	binding site for residue SO4 H 1206

Chain	Residue
H	ASN1055
H	ARG1056
H	HOH1411

site_id	AC6
Number of Residues	3
Details	binding site for residue EDO H 1207

Chain	Residue
H	ARG1056
H	CL1204
H	HOH1424

site_id	AC7
Number of Residues	3
Details	binding site for residue EDO H 1208

Chain	Residue
H	GLY26
H	CL1202
J	SER1058

site_id	AC8
Number of Residues	6
Details	binding site for residue EDO H 1209

Chain	Residue
H	GLN1016
H	TYR1032
H	ASP1033
H	EDO1217
H	HOH1312
H	HOH1370

site_id	AC9
Number of Residues	3
Details	binding site for residue EDO H 1210

Chain	Residue
H	PRO100
H	PRO1057
H	HOH1310

site_id	AD1
Number of Residues	5
Details	binding site for residue EDO H 1211

Chain	Residue
H	SER1061
H	ARG1063
H	GLN1081
H	GLU1083
H	HOH1305

site_id	AD2
Number of Residues	5
Details	binding site for residue EDO H 1212

Chain	Residue
H	LYS1068
H	SER1069
H	GLY1070
H	HOH1333
H	HOH1408

site_id	AD3
Number of Residues	9
Details	binding site for residue EDO H 1213

Chain	Residue
H	GLY42
H	GLN43
H	GLY44
H	THR1103
H	HOH1356
H	HOH1415
H	HOH1448
J	GLY42
J	HOH1399

site_id	AD4
Number of Residues	5
Details	binding site for residue EDO H 1214

Chain	Residue
H	GLN1039
H	LYS1047
H	LEU1049
H	VAL1060
H	HOH1305

site_id	AD5
Number of Residues	5
Details	binding site for residue EDO H 1215

Chain	Residue
H	ASN59
H	ALA1093
H	ASP1097
H	THR1098
H	HOH1394

site_id	AD6
Number of Residues	4
Details	binding site for residue EDO H 1216

Chain	Residue
H	SER30
H	SER31
H	TYR32
H	SER77

site_id	AD7
Number of Residues	5
Details	binding site for residue EDO H 1217

Chain	Residue
H	PRO110
H	ASP112
H	GLN1016
H	EDO1209
H	HOH1323

site_id	AD8
Number of Residues	6
Details	binding site for residue EDO H 1218

Chain	Residue
H	TYR102
H	ASP104
H	SER106
H	TYR109
H	HOH1473
J	SER75

site_id	AD9
Number of Residues	5
Details	binding site for residue EDO H 1219

Chain	Residue
H	SER1002
H	ALA1003
H	HOH1480
J	LYS1106
J	HOH1309

site_id	AE1
Number of Residues	2
Details	binding site for residue EDO H 1220

Chain	Residue
H	SER126
H	SER127

site_id	AE2
Number of Residues	3
Details	binding site for residue EDO H 1221

Chain	Residue
H	ALA9
H	GLU10
H	VAL11

site_id	AE3
Number of Residues	5
Details	binding site for residue EDO H 1222

Chain	Residue
H	THR1025
H	SER1026
H	ASN1071
H	HOH1432
J	HOH1444

site_id	AE4
Number of Residues	8
Details	binding site for residue EDO H 1223

Chain	Residue
H	LEU45
H	GLU46
H	TRP47
H	ALA1003
H	TYR1099
H	VAL1100
H	PHE1101
H	HOH1357

site_id	AE5
Number of Residues	7
Details	binding site for residue PEG H 1224

Chain	Residue
H	ASP104
H	SER105
H	SER1021
H	HOH1361
H	HOH1436
J	PEG1218
J	HOH1391

site_id	AE6
Number of Residues	2
Details	binding site for residue CL J 1201

Chain	Residue
J	LYS12
J	LYS13

site_id	AE7
Number of Residues	1
Details	binding site for residue CL J 1202

Chain	Residue
J	ASN1054

site_id	AE8
Number of Residues	4
Details	binding site for residue SO4 J 1203

Chain	Residue
J	ASN1055
J	ARG1056
J	HOH1371
J	HOH1456

site_id	AE9
Number of Residues	11
Details	binding site for residue SO4 J 1204

Chain	Residue
H	GLN1
H	GLY26
H	HOH1327
H	HOH1366
J	GLN1
J	VAL2
J	ARG98
J	ILE116
J	HOH1303
J	HOH1344
J	HOH1379

site_id	AF1
Number of Residues	4
Details	binding site for residue SO4 J 1205

Chain	Residue
J	LYS19
J	SER1069
J	GLY1070
J	HOH1329

site_id	AF2
Number of Residues	1
Details	binding site for residue EDO J 1206

Chain	Residue
J	GLY8

site_id	AF3
Number of Residues	3
Details	binding site for residue EDO J 1207

Chain	Residue
J	SER7
J	LYS19
J	HOH1319

site_id	AF4
Number of Residues	4
Details	binding site for residue EDO J 1208

Chain	Residue
J	GLN1039
J	LYS1047
J	VAL1060
J	SER1061

site_id	AF5
Number of Residues	8
Details	binding site for residue EDO J 1209

Chain	Residue
J	ALA24
J	SER31
J	TYR32
J	ILE34
J	PRO53
J	SER77
J	HOH1304
J	HOH1310

site_id	AF6
Number of Residues	5
Details	binding site for residue EDO J 1210

Chain	Residue
H	THR1023
J	TYR103
J	PEG1218
J	HOH1391
J	HOH1448

site_id	AF7
Number of Residues	3
Details	binding site for residue EDO J 1211

Chain	Residue
J	SER16
J	SER17
J	HOH1354

site_id	AF8
Number of Residues	4
Details	binding site for residue EDO J 1212

Chain	Residue
H	LYS1044
J	ARG87
J	SER88
J	HOH1454

site_id	AF9
Number of Residues	4
Details	binding site for residue EDO J 1213

Chain	Residue
J	SER1058
J	GLY1059
J	HOH1359
J	HOH1477

site_id	AG1
Number of Residues	5
Details	binding site for residue EDO J 1214

Chain	Residue
J	ILE111
J	PHE1051
J	HOH1336
J	HOH1342
J	HOH1486

site_id	AG2
Number of Residues	2
Details	binding site for residue EDO J 1215

Chain	Residue
J	SER1061
J	ARG1063

site_id	AG3
Number of Residues	7
Details	binding site for residue EDO J 1216

Chain	Residue
J	ASN59
J	ASP112
J	ALA1093
J	ASP1097
J	THR1098
J	TYR1099
J	HOH1480

site_id	AG4
Number of Residues	2
Details	binding site for residue EDO J 1217

Chain	Residue
J	SER126
J	HOH1384

site_id	AG5
Number of Residues	8
Details	binding site for residue PEG J 1218

Chain	Residue
H	PEG1224
J	ILE54
J	PHE55
J	SER1009
J	SER1011
J	EDO1210
J	HOH1324
J	HOH1391

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	194
Details	Domain: {"description":"Ig-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	48
Details	Region: {"description":"Framework-1","evidences":[{"source":"UniProtKB","id":"P23083","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	14
Details	Region: {"description":"Complementarity-determining-1","evidences":[{"source":"UniProtKB","id":"P23083","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	32
Details	Region: {"description":"Framework-2","evidences":[{"source":"UniProtKB","id":"P23083","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	14
Details	Region: {"description":"Complementarity-determining-2","evidences":[{"source":"UniProtKB","id":"P23083","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	74
Details	Region: {"description":"Framework-3","evidences":[{"source":"UniProtKB","id":"P23083","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	2
Details	Region: {"description":"Complementarity-determining-3","evidences":[{"source":"UniProtKB","id":"P23083","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Pyrrolidone carboxylic acid","evidences":[{"source":"UniProtKB","id":"P01742","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	48
Details	Region: {"description":"Framework-1","evidences":[{"source":"UniProtKB","id":"P01721","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	16
Details	Region: {"description":"Complementarity-determining-1","evidences":[{"source":"UniProtKB","id":"P01721","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	32
Details	Region: {"description":"Framework-2","evidences":[{"source":"UniProtKB","id":"P01721","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	4
Details	Region: {"description":"Complementarity-determining-2","evidences":[{"source":"UniProtKB","id":"P01721","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	70
Details	Region: {"description":"Framework-3","evidences":[{"source":"UniProtKB","id":"P01721","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	2
Details	Modified residue: {"description":"Pyrrolidone carboxylic acid","evidences":[{"source":"PubMed","id":"500108","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)