5C55

Crystal structure of the Y138F mutant of C.glutamicum N-acetylneuraminic acid lyase in complex with pyruvate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008747	molecular_function	N-acetylneuraminate lyase activity
A	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
A	0016829	molecular_function	lyase activity
B	0008747	molecular_function	N-acetylneuraminate lyase activity
B	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
B	0016829	molecular_function	lyase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue PYR A 401

Chain	Residue
A	PRO12
A	GLY47
A	SER48
A	SER49
A	LYS166
A	SER168
A	VAL213
A	HOH559
A	HOH638

---

site_id	AC2
Number of Residues	2
Details	binding site for residue EDO A 402

Chain	Residue
A	EDO403
A	EDO405

---

site_id	AC3
Number of Residues	2
Details	binding site for residue EDO A 403

Chain	Residue
A	PRO150
A	EDO402

---

site_id	AC4
Number of Residues	1
Details	binding site for residue EDO A 404

Chain	Residue
A	ASP41

---

site_id	AC5
Number of Residues	1
Details	binding site for residue EDO A 405

Chain	Residue
A	EDO402

---

site_id	AC6
Number of Residues	4
Details	binding site for residue EDO A 406

Chain	Residue
A	LYS30
A	ILE280
A	ILE281
A	GLU282

---

site_id	AC7
Number of Residues	1
Details	binding site for residue EDO A 407

Chain	Residue
A	LYS125

---

site_id	AC8
Number of Residues	2
Details	binding site for residue ACT A 408

Chain	Residue
A	THR199
A	HOH609

---

site_id	AC9
Number of Residues	2
Details	binding site for residue ACT A 409

Chain	Residue
A	LYS158
A	HIS277

---

site_id	AD1
Number of Residues	5
Details	binding site for residue EDO A 410

Chain	Residue
A	ARG113
A	HOH501
B	VAL253
B	GLY263
B	GOL403

---

site_id	AD2
Number of Residues	2
Details	binding site for residue EDO B 401

Chain	Residue
A	VAL253
B	ARG113

---

site_id	AD3
Number of Residues	5
Details	binding site for residue GOL B 403

Chain	Residue
A	ARG113
A	EDO410
B	SER49
B	GLU198
B	PYR402

---

site_id	AD4
Number of Residues	5
Details	binding site for residue EDO B 405

Chain	Residue
B	GLY8
B	TYR205
B	ASP210
B	LEU232
B	HOH525

---

site_id	AD5
Number of Residues	1
Details	binding site for residue EDO B 406

Chain	Residue
B	LYS158

---

site_id	AD6
Number of Residues	2
Details	binding site for residue ACT B 407

Chain	Residue
B	TYR205
B	HOH646

---

site_id	AD7
Number of Residues	16
Details	binding site for Di-peptide PYR B 402 and LYS B 166

Chain	Residue
B	PRO12
B	PHE44
B	SER48
B	SER49
B	VAL105
B	PHE136
B	ALA137
B	PHE138
B	ASN139
B	THR165
B	ASP167
B	SER168
B	LEU194
B	VAL213
B	GOL403
B	HOH591

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