5C53

Probing the Structural and Molecular Basis of Nucleotide Selectivity by Human Mitochondrial DNA Polymerase gamma

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000262	cellular_component	mitochondrial chromosome
A	0002020	molecular_function	protease binding
A	0003677	molecular_function	DNA binding
A	0003682	molecular_function	chromatin binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005760	cellular_component	gamma DNA polymerase complex
A	0006259	biological_process	DNA metabolic process
A	0006260	biological_process	DNA replication
A	0006261	biological_process	DNA-templated DNA replication
A	0006264	biological_process	mitochondrial DNA replication
A	0006281	biological_process	DNA repair
A	0006284	biological_process	base-excision repair
A	0006287	biological_process	base-excision repair, gap-filling
A	0008310	molecular_function	single-stranded DNA 3'-5' DNA exonuclease activity
A	0008408	molecular_function	3'-5' exonuclease activity
A	0016787	molecular_function	hydrolase activity
A	0016829	molecular_function	lyase activity
A	0032991	cellular_component	protein-containing complex
A	0034061	molecular_function	DNA polymerase activity
A	0042645	cellular_component	mitochondrial nucleoid
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0045004	biological_process	DNA replication proofreading
A	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
A	0071897	biological_process	DNA biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue MG A 4001

Chain	Residue
A	ASP1135
A	4Y34003

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site_id	AC2
Number of Residues	4
Details	binding site for residue MG A 4002

Chain	Residue
A	ASP890
A	VAL891
A	ASP1135
A	4Y34003

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site_id	AC3
Number of Residues	14
Details	binding site for residue 4Y3 A 4003

Chain	Residue
A	GLN894
A	GLU895
A	HIS932
A	ARG943
A	LYS947
A	TYR951
A	ASP1135
A	MG4001
A	MG4002
T	DG4
T	DA5
A	ASP890
A	ASP892
A	SER893

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Functional Information from PROSITE/UniProt

site_id	PS00447
Number of Residues	20
Details	DNA_POLYMERASE_A DNA polymerase family A signature. RehAKifnYGriYgaGqpfA

Chain	Residue	Details
A	ARG943-ALA962

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
B	SER38
C	SER38

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site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:37202477, ECO:0007744|PDB:8D37

Chain	Residue	Details
A	LYS316
A	LEU816
A	GLY903
A	ARG953
A	ALA1105

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000305|PubMed:26056153, ECO:0007744|PDB:4ZTZ

Chain	Residue	Details
A	PRO589
A	GLN879

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site_id	SWS_FT_FI4
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:26056153, ECO:0000269|PubMed:37202477, ECO:0007744|PDB:4ZTZ, ECO:0007744|PDB:8D37

Chain	Residue	Details
A	MET603
A	ALA957
A	PHE961

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: BINDING => ECO:0000305|PubMed:37202477, ECO:0007744|PDB:8D37

Chain	Residue	Details
A	SER764
A	LYS773
A	THR778
A	GLU873

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:26056153, ECO:0007744|PDB:4ZTZ

Chain	Residue	Details
A	TRP859
A	ALA900
A	VAL901
A	ALA905
A	SER1104
A	ASP1145

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site_id	SWS_FT_FI7
Number of Residues	2
Details	SITE: Critical for replication fidelity and mismatch recognition => ECO:0000269|PubMed:37202477

Chain	Residue	Details
A	SER863
A	MET1112

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