5C53

Probing the Structural and Molecular Basis of Nucleotide Selectivity by Human Mitochondrial DNA Polymerase gamma

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000262	cellular_component	mitochondrial chromosome
A	0002020	molecular_function	protease binding
A	0003677	molecular_function	DNA binding
A	0003682	molecular_function	chromatin binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005760	cellular_component	gamma DNA polymerase complex
A	0006259	biological_process	DNA metabolic process
A	0006260	biological_process	DNA replication
A	0006261	biological_process	DNA-templated DNA replication
A	0006264	biological_process	mitochondrial DNA replication
A	0006281	biological_process	DNA repair
A	0006284	biological_process	base-excision repair
A	0006287	biological_process	base-excision repair, gap-filling
A	0008310	molecular_function	single-stranded DNA 3'-5' DNA exonuclease activity
A	0008408	molecular_function	3'-5' exonuclease activity
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0016787	molecular_function	hydrolase activity
A	0016829	molecular_function	lyase activity
A	0032991	cellular_component	protein-containing complex
A	0034061	molecular_function	DNA polymerase activity
A	0042645	cellular_component	mitochondrial nucleoid
A	0045004	biological_process	DNA replication proofreading
A	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
A	0071897	biological_process	DNA biosynthetic process
A	0140640	molecular_function	catalytic activity, acting on a nucleic acid

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue MG A 4001

Chain	Residue
A	ASP1135
A	4Y34003

---

site_id	AC2
Number of Residues	4
Details	binding site for residue MG A 4002

Chain	Residue
A	ASP890
A	VAL891
A	ASP1135
A	4Y34003

---

site_id	AC3
Number of Residues	14
Details	binding site for residue 4Y3 A 4003

Chain	Residue
A	GLN894
A	GLU895
A	HIS932
A	ARG943
A	LYS947
A	TYR951
A	ASP1135
A	MG4001
A	MG4002
T	DG4
T	DA5
A	ASP890
A	ASP892
A	SER893

---

Functional Information from PROSITE/UniProt

site_id	PS00447
Number of Residues	20
Details	DNA_POLYMERASE_A DNA polymerase family A signature. RehAKifnYGriYgaGqpfA

Chain	Residue	Details
A	ARG943-ALA962

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Region: {"description":"Trigger loop","evidences":[{"source":"PubMed","id":"37202477","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Motif: {"description":"Exo I","evidences":[{"source":"PubMed","id":"15189144","evidenceCode":"ECO:0000303"},{"source":"PubMed","id":"8884268","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Motif: {"description":"Exo II","evidences":[{"source":"PubMed","id":"15189144","evidenceCode":"ECO:0000303"},{"source":"PubMed","id":"8884268","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Motif: {"description":"Exo III","evidences":[{"source":"PubMed","id":"15189144","evidenceCode":"ECO:0000303"},{"source":"PubMed","id":"8884268","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	9
Details	Motif: {"description":"Pol A","evidences":[{"source":"PubMed","id":"15189144","evidenceCode":"ECO:0000303"},{"source":"PubMed","id":"8884268","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	15
Details	Motif: {"description":"Pol B","evidences":[{"source":"PubMed","id":"15189144","evidenceCode":"ECO:0000303"},{"source":"PubMed","id":"8884268","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	7
Details	Motif: {"description":"Pol C","evidences":[{"source":"PubMed","id":"15189144","evidenceCode":"ECO:0000303"},{"source":"PubMed","id":"8884268","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Active site: {"description":"Exonuclease activity","evidences":[{"source":"PubMed","id":"37202477","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37202477","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8D37","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26056153","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4ZTZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26056153","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37202477","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ZTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D37","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37202477","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8D37","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26056153","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ZTZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	Site: {"description":"Critical for replication fidelity and mismatch recognition","evidences":[{"source":"PubMed","id":"37202477","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---