5C46

Crystal structure of an engineered construct of phosphatidylinositol 4 kinase III beta in complex with GTP gamma S loaded Rab11

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0016301	molecular_function	kinase activity
E	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
F	0000139	cellular_component	Golgi membrane
F	0000166	molecular_function	nucleotide binding
F	0000922	cellular_component	spindle pole
F	0003924	molecular_function	GTPase activity
F	0003925	molecular_function	G protein activity
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005737	cellular_component	cytoplasm
F	0005771	cellular_component	multivesicular body
F	0005794	cellular_component	Golgi apparatus
F	0005802	cellular_component	trans-Golgi network
F	0005813	cellular_component	centrosome
F	0005814	cellular_component	centriole
F	0005828	cellular_component	kinetochore microtubule
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0005929	cellular_component	cilium
F	0006887	biological_process	exocytosis
F	0007080	biological_process	mitotic metaphase chromosome alignment
F	0008017	molecular_function	microtubule binding
F	0010008	cellular_component	endosome membrane
F	0010634	biological_process	positive regulation of epithelial cell migration
F	0010971	biological_process	positive regulation of G2/M transition of mitotic cell cycle
F	0015031	biological_process	protein transport
F	0016020	cellular_component	membrane
F	0016192	biological_process	vesicle-mediated transport
F	0016787	molecular_function	hydrolase activity
F	0019905	molecular_function	syntaxin binding
F	0030133	cellular_component	transport vesicle
F	0030659	cellular_component	cytoplasmic vesicle membrane
F	0030666	cellular_component	endocytic vesicle membrane
F	0030672	cellular_component	synaptic vesicle membrane
F	0030953	biological_process	astral microtubule organization
F	0031175	biological_process	neuron projection development
F	0031410	cellular_component	cytoplasmic vesicle
F	0031489	molecular_function	myosin V binding
F	0031982	cellular_component	vesicle
F	0032154	cellular_component	cleavage furrow
F	0032402	biological_process	melanosome transport
F	0032465	biological_process	regulation of cytokinesis
F	0032588	cellular_component	trans-Golgi network membrane
F	0032991	cellular_component	protein-containing complex
F	0034451	cellular_component	centriolar satellite
F	0036258	biological_process	multivesicular body assembly
F	0043001	biological_process	Golgi to plasma membrane protein transport
F	0045335	cellular_component	phagocytic vesicle
F	0048169	biological_process	regulation of long-term neuronal synaptic plasticity
F	0048227	biological_process	plasma membrane to endosome transport
F	0051223	biological_process	regulation of protein transport
F	0051650	biological_process	establishment of vesicle localization
F	0051959	molecular_function	dynein light intermediate chain binding
F	0055037	cellular_component	recycling endosome
F	0055038	cellular_component	recycling endosome membrane
F	0060627	biological_process	regulation of vesicle-mediated transport
F	0061502	biological_process	early endosome to recycling endosome transport
F	0061512	biological_process	protein localization to cilium
F	0070062	cellular_component	extracellular exosome
F	0072594	biological_process	establishment of protein localization to organelle
F	0072659	biological_process	protein localization to plasma membrane
F	0090150	biological_process	establishment of protein localization to membrane
F	0090307	biological_process	mitotic spindle assembly
F	0098685	cellular_component	Schaffer collateral - CA1 synapse
F	0098830	cellular_component	presynaptic endosome
F	0098837	cellular_component	postsynaptic recycling endosome
F	0098876	biological_process	vesicle-mediated transport to the plasma membrane
F	0098887	biological_process	neurotransmitter receptor transport, endosome to postsynaptic membrane
F	0098978	cellular_component	glutamatergic synapse
F	0099532	biological_process	synaptic vesicle endosomal processing
F	0150093	biological_process	amyloid-beta clearance by transcytosis
F	1902017	biological_process	regulation of cilium assembly
F	1902954	biological_process	regulation of early endosome to recycling endosome transport
F	1903078	biological_process	positive regulation of protein localization to plasma membrane
F	1903438	biological_process	positive regulation of mitotic cytokinetic process
F	1904779	biological_process	regulation of protein localization to centrosome
F	1990182	biological_process	exosomal secretion
F	2001135	biological_process	regulation of endocytic recycling

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue SO4 E 801

Chain	Residue
E	HIS605
E	LYS608

---

site_id	AC2
Number of Residues	6
Details	binding site for residue SO4 E 802

Chain	Residue
E	TYR183
E	LYS195
E	ARG232
E	GLY233
E	LYS235
E	LEU236

---

site_id	AC3
Number of Residues	23
Details	binding site for residue GSP F 2000

Chain	Residue
F	SER20
F	GLY21
F	VAL22
F	GLY23
F	LYS24
F	SER25
F	ASN26
F	PHE36
F	ASN37
F	LEU38
F	SER40
F	SER42
F	THR43
F	GLY69
F	ASN124
F	LYS125
F	ASP127
F	LEU128
F	SER154
F	ALA155
F	LEU156
F	MG2001
E	GLY155

---

site_id	AC4
Number of Residues	3
Details	binding site for residue MG F 2001

Chain	Residue
F	SER25
F	THR43
F	GSP2000

---

Functional Information from PROSITE/UniProt

site_id	PS00675
Number of Residues	14
Details	SIGMA54_INTERACT_1 Sigma-54 interaction domain ATP-binding region A signature. VVLiGDSGVGKsnL

Chain	Residue	Details
F	VAL14-LEU27

---

site_id	PS00915
Number of Residues	15
Details	PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. VKcg.DDLRQEllafQ

Chain	Residue	Details
E	VAL548-GLN562

---

site_id	PS00916
Number of Residues	21
Details	PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgycLvcYLLqVkDRHngN

Chain	Residue	Details
E	SER641-ASN661

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Region: {"description":"G-loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Region: {"description":"Catalytic loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	11
Details	Motif: {"description":"Switch 1","evidences":[{"source":"PubMed","id":"17007872","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2HV8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	19
Details	Motif: {"description":"Switch 2","evidences":[{"source":"PubMed","id":"17007872","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2HV8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16905101","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17030804","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2D7C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16905101","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17007872","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17030804","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2D7C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HV8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16905101","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2GZH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15837192","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16034420","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16905101","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17007872","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17030804","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1OIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YZK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2D7C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HV8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16905101","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17007872","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17030804","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2GZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16905101","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17030804","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2D7C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16905101","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17007872","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17030804","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2D7C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---