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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5C3I

Crystal structure of the quaternary complex of histone H3-H4 heterodimer with chaperone ASF1 and the replicative helicase subunit MCM2

Functional Information from GO Data
ChainGOidnamespacecontents
A0005634cellular_componentnucleus
A0006325biological_processchromatin organization
B0000786cellular_componentnucleosome
B0003677molecular_functionDNA binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005694cellular_componentchromosome
B0006325biological_processchromatin organization
B0006334biological_processnucleosome assembly
B0016020cellular_componentmembrane
B0030527molecular_functionstructural constituent of chromatin
B0031492molecular_functionnucleosomal DNA binding
B0031507biological_processheterochromatin formation
B0032200biological_processtelomere organization
B0032991cellular_componentprotein-containing complex
B0040029biological_processepigenetic regulation of gene expression
B0045296molecular_functioncadherin binding
B0046982molecular_functionprotein heterodimerization activity
B0070062cellular_componentextracellular exosome
C0000781cellular_componentchromosome, telomeric region
C0000786cellular_componentnucleosome
C0003677molecular_functionDNA binding
C0003723molecular_functionRNA binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005694cellular_componentchromosome
C0006325biological_processchromatin organization
C0006334biological_processnucleosome assembly
C0016020cellular_componentmembrane
C0030527molecular_functionstructural constituent of chromatin
C0032200biological_processtelomere organization
C0032991cellular_componentprotein-containing complex
C0045653biological_processnegative regulation of megakaryocyte differentiation
C0046982molecular_functionprotein heterodimerization activity
C0061644biological_processprotein localization to CENP-A containing chromatin
C0070062cellular_componentextracellular exosome
D0003677molecular_functionDNA binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0006270biological_processDNA replication initiation
D0042555cellular_componentMCM complex
E0005634cellular_componentnucleus
E0006325biological_processchromatin organization
F0000786cellular_componentnucleosome
F0003677molecular_functionDNA binding
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005694cellular_componentchromosome
F0006325biological_processchromatin organization
F0006334biological_processnucleosome assembly
F0016020cellular_componentmembrane
F0030527molecular_functionstructural constituent of chromatin
F0031492molecular_functionnucleosomal DNA binding
F0031507biological_processheterochromatin formation
F0032200biological_processtelomere organization
F0032991cellular_componentprotein-containing complex
F0040029biological_processepigenetic regulation of gene expression
F0045296molecular_functioncadherin binding
F0046982molecular_functionprotein heterodimerization activity
F0070062cellular_componentextracellular exosome
G0000781cellular_componentchromosome, telomeric region
G0000786cellular_componentnucleosome
G0003677molecular_functionDNA binding
G0003723molecular_functionRNA binding
G0005515molecular_functionprotein binding
G0005576cellular_componentextracellular region
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005694cellular_componentchromosome
G0006325biological_processchromatin organization
G0006334biological_processnucleosome assembly
G0016020cellular_componentmembrane
G0030527molecular_functionstructural constituent of chromatin
G0032200biological_processtelomere organization
G0032991cellular_componentprotein-containing complex
G0045653biological_processnegative regulation of megakaryocyte differentiation
G0046982molecular_functionprotein heterodimerization activity
G0061644biological_processprotein localization to CENP-A containing chromatin
G0070062cellular_componentextracellular exosome
H0003677molecular_functionDNA binding
H0005524molecular_functionATP binding
H0005634cellular_componentnucleus
H0006270biological_processDNA replication initiation
H0042555cellular_componentMCM complex
I0005634cellular_componentnucleus
I0006325biological_processchromatin organization
J0000786cellular_componentnucleosome
J0003677molecular_functionDNA binding
J0005515molecular_functionprotein binding
J0005576cellular_componentextracellular region
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0005694cellular_componentchromosome
J0006325biological_processchromatin organization
J0006334biological_processnucleosome assembly
J0016020cellular_componentmembrane
J0030527molecular_functionstructural constituent of chromatin
J0031492molecular_functionnucleosomal DNA binding
J0031507biological_processheterochromatin formation
J0032200biological_processtelomere organization
J0032991cellular_componentprotein-containing complex
J0040029biological_processepigenetic regulation of gene expression
J0045296molecular_functioncadherin binding
J0046982molecular_functionprotein heterodimerization activity
J0070062cellular_componentextracellular exosome
K0000781cellular_componentchromosome, telomeric region
K0000786cellular_componentnucleosome
K0003677molecular_functionDNA binding
K0003723molecular_functionRNA binding
K0005515molecular_functionprotein binding
K0005576cellular_componentextracellular region
K0005634cellular_componentnucleus
K0005654cellular_componentnucleoplasm
K0005694cellular_componentchromosome
K0006325biological_processchromatin organization
K0006334biological_processnucleosome assembly
K0016020cellular_componentmembrane
K0030527molecular_functionstructural constituent of chromatin
K0032200biological_processtelomere organization
K0032991cellular_componentprotein-containing complex
K0045653biological_processnegative regulation of megakaryocyte differentiation
K0046982molecular_functionprotein heterodimerization activity
K0061644biological_processprotein localization to CENP-A containing chromatin
K0070062cellular_componentextracellular exosome
L0003677molecular_functionDNA binding
L0005524molecular_functionATP binding
L0005634cellular_componentnucleus
L0006270biological_processDNA replication initiation
L0042555cellular_componentMCM complex
M0005634cellular_componentnucleus
M0006325biological_processchromatin organization
N0000786cellular_componentnucleosome
N0003677molecular_functionDNA binding
N0005515molecular_functionprotein binding
N0005576cellular_componentextracellular region
N0005634cellular_componentnucleus
N0005654cellular_componentnucleoplasm
N0005694cellular_componentchromosome
N0006325biological_processchromatin organization
N0006334biological_processnucleosome assembly
N0016020cellular_componentmembrane
N0030527molecular_functionstructural constituent of chromatin
N0031492molecular_functionnucleosomal DNA binding
N0031507biological_processheterochromatin formation
N0032200biological_processtelomere organization
N0032991cellular_componentprotein-containing complex
N0040029biological_processepigenetic regulation of gene expression
N0045296molecular_functioncadherin binding
N0046982molecular_functionprotein heterodimerization activity
N0070062cellular_componentextracellular exosome
O0000781cellular_componentchromosome, telomeric region
O0000786cellular_componentnucleosome
O0003677molecular_functionDNA binding
O0003723molecular_functionRNA binding
O0005515molecular_functionprotein binding
O0005576cellular_componentextracellular region
O0005634cellular_componentnucleus
O0005654cellular_componentnucleoplasm
O0005694cellular_componentchromosome
O0006325biological_processchromatin organization
O0006334biological_processnucleosome assembly
O0016020cellular_componentmembrane
O0030527molecular_functionstructural constituent of chromatin
O0032200biological_processtelomere organization
O0032991cellular_componentprotein-containing complex
O0045653biological_processnegative regulation of megakaryocyte differentiation
O0046982molecular_functionprotein heterodimerization activity
O0061644biological_processprotein localization to CENP-A containing chromatin
O0070062cellular_componentextracellular exosome
P0003677molecular_functionDNA binding
P0005524molecular_functionATP binding
P0005634cellular_componentnucleus
P0006270biological_processDNA replication initiation
P0042555cellular_componentMCM complex
Q0005634cellular_componentnucleus
Q0006325biological_processchromatin organization
R0000786cellular_componentnucleosome
R0003677molecular_functionDNA binding
R0005515molecular_functionprotein binding
R0005576cellular_componentextracellular region
R0005634cellular_componentnucleus
R0005654cellular_componentnucleoplasm
R0005694cellular_componentchromosome
R0006325biological_processchromatin organization
R0006334biological_processnucleosome assembly
R0016020cellular_componentmembrane
R0030527molecular_functionstructural constituent of chromatin
R0031492molecular_functionnucleosomal DNA binding
R0031507biological_processheterochromatin formation
R0032200biological_processtelomere organization
R0032991cellular_componentprotein-containing complex
R0040029biological_processepigenetic regulation of gene expression
R0045296molecular_functioncadherin binding
R0046982molecular_functionprotein heterodimerization activity
R0070062cellular_componentextracellular exosome
S0000781cellular_componentchromosome, telomeric region
S0000786cellular_componentnucleosome
S0003677molecular_functionDNA binding
S0003723molecular_functionRNA binding
S0005515molecular_functionprotein binding
S0005576cellular_componentextracellular region
S0005634cellular_componentnucleus
S0005654cellular_componentnucleoplasm
S0005694cellular_componentchromosome
S0006325biological_processchromatin organization
S0006334biological_processnucleosome assembly
S0016020cellular_componentmembrane
S0030527molecular_functionstructural constituent of chromatin
S0032200biological_processtelomere organization
S0032991cellular_componentprotein-containing complex
S0045653biological_processnegative regulation of megakaryocyte differentiation
S0046982molecular_functionprotein heterodimerization activity
S0061644biological_processprotein localization to CENP-A containing chromatin
S0070062cellular_componentextracellular exosome
T0003677molecular_functionDNA binding
T0005524molecular_functionATP binding
T0005634cellular_componentnucleus
T0006270biological_processDNA replication initiation
T0042555cellular_componentMCM complex
U0005634cellular_componentnucleus
U0006325biological_processchromatin organization
V0000786cellular_componentnucleosome
V0003677molecular_functionDNA binding
V0005515molecular_functionprotein binding
V0005576cellular_componentextracellular region
V0005634cellular_componentnucleus
V0005654cellular_componentnucleoplasm
V0005694cellular_componentchromosome
V0006325biological_processchromatin organization
V0006334biological_processnucleosome assembly
V0016020cellular_componentmembrane
V0030527molecular_functionstructural constituent of chromatin
V0031492molecular_functionnucleosomal DNA binding
V0031507biological_processheterochromatin formation
V0032200biological_processtelomere organization
V0032991cellular_componentprotein-containing complex
V0040029biological_processepigenetic regulation of gene expression
V0045296molecular_functioncadherin binding
V0046982molecular_functionprotein heterodimerization activity
V0070062cellular_componentextracellular exosome
W0000781cellular_componentchromosome, telomeric region
W0000786cellular_componentnucleosome
W0003677molecular_functionDNA binding
W0003723molecular_functionRNA binding
W0005515molecular_functionprotein binding
W0005576cellular_componentextracellular region
W0005634cellular_componentnucleus
W0005654cellular_componentnucleoplasm
W0005694cellular_componentchromosome
W0006325biological_processchromatin organization
W0006334biological_processnucleosome assembly
W0016020cellular_componentmembrane
W0030527molecular_functionstructural constituent of chromatin
W0032200biological_processtelomere organization
W0032991cellular_componentprotein-containing complex
W0045653biological_processnegative regulation of megakaryocyte differentiation
W0046982molecular_functionprotein heterodimerization activity
W0061644biological_processprotein localization to CENP-A containing chromatin
W0070062cellular_componentextracellular exosome
X0003677molecular_functionDNA binding
X0005524molecular_functionATP binding
X0005634cellular_componentnucleus
X0006270biological_processDNA replication initiation
X0042555cellular_componentMCM complex
Functional Information from PROSITE/UniProt
site_idPS00047
Number of Residues5
DetailsHISTONE_H4 Histone H4 signature. GAKRH
ChainResidueDetails
CGLY14-HIS18
site_idPS00322
Number of Residues7
DetailsHISTONE_H3_1 Histone H3 signature 1. KAPRKQL
ChainResidueDetails
BLYS14-LEU20
site_idPS00959
Number of Residues9
DetailsHISTONE_H3_2 Histone H3 signature 2. PFqRLVREI
ChainResidueDetails
BPRO66-ILE74
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues36
DetailsMotif: {"description":"Required for interaction with HIRA","evidences":[{"source":"PubMed","id":"15621527","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16980972","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues21
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues3
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20850016","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues6
DetailsModified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"16267050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues6
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29211711","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues6
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20850016","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues6
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P84243","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues6
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q71DI3","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues12
DetailsModified residue: {"description":"N6-glutaryllysine; alternate","evidences":[{"source":"PubMed","id":"31542297","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues6
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27436229","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues6
DetailsModified residue: {"description":"N6-propionyllysine; alternate","evidences":[{"source":"PubMed","id":"17267393","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues6
DetailsModified residue: {"description":"Phosphoserine; by PAK2","evidences":[{"source":"PubMed","id":"21724829","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues6
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues6
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62806","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues6
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P62806","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues6
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues6
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate","evidences":[{"source":"PubMed","id":"30886146","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues12
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"19818714","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues12
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues6
DetailsModified residue: {"description":"Phosphoserine; by ATR","evidences":[{"source":"PubMed","id":"15210935","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16899510","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17525332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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