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5C09

HLA class I histocompatibility antigen

Functional Information from GO Data
ChainGOidnamespacecontents
B0000139cellular_componentGolgi membrane
B0001913biological_processT cell mediated cytotoxicity
B0001916biological_processpositive regulation of T cell mediated cytotoxicity
B0002237biological_processresponse to molecule of bacterial origin
B0002376biological_processimmune system process
B0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
B0002481biological_processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B0002502biological_processpeptide antigen assembly with MHC class I protein complex
B0002503biological_processpeptide antigen assembly with MHC class II protein complex
B0002726biological_processpositive regulation of T cell cytokine production
B0005198molecular_functionstructural molecule activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005765cellular_componentlysosomal membrane
B0005783cellular_componentendoplasmic reticulum
B0005788cellular_componentendoplasmic reticulum lumen
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0006826biological_processiron ion transport
B0006879biological_processintracellular iron ion homeostasis
B0006955biological_processimmune response
B0007608biological_processsensory perception of smell
B0007611biological_processlearning or memory
B0009897cellular_componentexternal side of plasma membrane
B0009986cellular_componentcell surface
B0010977biological_processnegative regulation of neuron projection development
B0012507cellular_componentER to Golgi transport vesicle membrane
B0016020cellular_componentmembrane
B0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
B0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
B0023026molecular_functionMHC class II protein complex binding
B0030670cellular_componentphagocytic vesicle membrane
B0031901cellular_componentearly endosome membrane
B0031902cellular_componentlate endosome membrane
B0031905cellular_componentearly endosome lumen
B0032092biological_processpositive regulation of protein binding
B0033077biological_processT cell differentiation in thymus
B0034756biological_processregulation of iron ion transport
B0035580cellular_componentspecific granule lumen
B0042026biological_processprotein refolding
B0042605molecular_functionpeptide antigen binding
B0042612cellular_componentMHC class I protein complex
B0042613cellular_componentMHC class II protein complex
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0042824cellular_componentMHC class I peptide loading complex
B0045646biological_processregulation of erythrocyte differentiation
B0048260biological_processpositive regulation of receptor-mediated endocytosis
B0050680biological_processnegative regulation of epithelial cell proliferation
B0050768biological_processnegative regulation of neurogenesis
B0050778biological_processpositive regulation of immune response
B0050870biological_processpositive regulation of T cell activation
B0051289biological_processprotein homotetramerization
B0055038cellular_componentrecycling endosome membrane
B0060586biological_processmulticellular organismal-level iron ion homeostasis
B0070062cellular_componentextracellular exosome
B0071281biological_processcellular response to iron ion
B0071283biological_processcellular response to iron(III) ion
B0071316biological_processcellular response to nicotine
B1900121biological_processnegative regulation of receptor binding
B1900122biological_processpositive regulation of receptor binding
B1904434biological_processpositive regulation of ferrous iron binding
B1904437biological_processpositive regulation of transferrin receptor binding
B1904724cellular_componenttertiary granule lumen
B1990000biological_processamyloid fibril formation
B1990712cellular_componentHFE-transferrin receptor complex
B2000774biological_processpositive regulation of cellular senescence
B2000978biological_processnegative regulation of forebrain neuron differentiation
D0002250biological_processadaptive immune response
D0002376biological_processimmune system process
D0005886cellular_componentplasma membrane
D0016020cellular_componentmembrane
D0042101cellular_componentT cell receptor complex
D0042605molecular_functionpeptide antigen binding
G0000139cellular_componentGolgi membrane
G0001913biological_processT cell mediated cytotoxicity
G0001916biological_processpositive regulation of T cell mediated cytotoxicity
G0002237biological_processresponse to molecule of bacterial origin
G0002376biological_processimmune system process
G0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
G0002481biological_processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
G0002502biological_processpeptide antigen assembly with MHC class I protein complex
G0002503biological_processpeptide antigen assembly with MHC class II protein complex
G0002726biological_processpositive regulation of T cell cytokine production
G0005198molecular_functionstructural molecule activity
G0005515molecular_functionprotein binding
G0005576cellular_componentextracellular region
G0005615cellular_componentextracellular space
G0005765cellular_componentlysosomal membrane
G0005783cellular_componentendoplasmic reticulum
G0005788cellular_componentendoplasmic reticulum lumen
G0005794cellular_componentGolgi apparatus
G0005829cellular_componentcytosol
G0005886cellular_componentplasma membrane
G0005925cellular_componentfocal adhesion
G0006826biological_processiron ion transport
G0006879biological_processintracellular iron ion homeostasis
G0006955biological_processimmune response
G0007608biological_processsensory perception of smell
G0007611biological_processlearning or memory
G0009897cellular_componentexternal side of plasma membrane
G0009986cellular_componentcell surface
G0010977biological_processnegative regulation of neuron projection development
G0012507cellular_componentER to Golgi transport vesicle membrane
G0016020cellular_componentmembrane
G0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
G0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
G0023026molecular_functionMHC class II protein complex binding
G0030670cellular_componentphagocytic vesicle membrane
G0031901cellular_componentearly endosome membrane
G0031902cellular_componentlate endosome membrane
G0031905cellular_componentearly endosome lumen
G0032092biological_processpositive regulation of protein binding
G0033077biological_processT cell differentiation in thymus
G0034756biological_processregulation of iron ion transport
G0035580cellular_componentspecific granule lumen
G0042026biological_processprotein refolding
G0042605molecular_functionpeptide antigen binding
G0042612cellular_componentMHC class I protein complex
G0042613cellular_componentMHC class II protein complex
G0042802molecular_functionidentical protein binding
G0042803molecular_functionprotein homodimerization activity
G0042824cellular_componentMHC class I peptide loading complex
G0045646biological_processregulation of erythrocyte differentiation
G0048260biological_processpositive regulation of receptor-mediated endocytosis
G0050680biological_processnegative regulation of epithelial cell proliferation
G0050768biological_processnegative regulation of neurogenesis
G0050778biological_processpositive regulation of immune response
G0050870biological_processpositive regulation of T cell activation
G0051289biological_processprotein homotetramerization
G0055038cellular_componentrecycling endosome membrane
G0060586biological_processmulticellular organismal-level iron ion homeostasis
G0070062cellular_componentextracellular exosome
G0071281biological_processcellular response to iron ion
G0071283biological_processcellular response to iron(III) ion
G0071316biological_processcellular response to nicotine
G1900121biological_processnegative regulation of receptor binding
G1900122biological_processpositive regulation of receptor binding
G1904434biological_processpositive regulation of ferrous iron binding
G1904437biological_processpositive regulation of transferrin receptor binding
G1904724cellular_componenttertiary granule lumen
G1990000biological_processamyloid fibril formation
G1990712cellular_componentHFE-transferrin receptor complex
G2000774biological_processpositive regulation of cellular senescence
G2000978biological_processnegative regulation of forebrain neuron differentiation
I0002250biological_processadaptive immune response
I0002376biological_processimmune system process
I0005886cellular_componentplasma membrane
I0016020cellular_componentmembrane
I0042101cellular_componentT cell receptor complex
I0042605molecular_functionpeptide antigen binding
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue SO4 A 301
ChainResidue
AARG17
AGLY18
AHOH410
JARG22
JPHE74

site_idAC2
Number of Residues2
Detailsbinding site for residue SO4 A 302
ChainResidue
ALYS121
AASP122

site_idAC3
Number of Residues6
Detailsbinding site for residue SO4 A 303
ChainResidue
ALYS121
AASP122
ATYR123
AASP137
ATYR85
ATYR118

site_idAC4
Number of Residues6
Detailsbinding site for residue SO4 D 301
ChainResidue
DLEU11
DILE18
DVAL19
DSER20
ITYR71
IPHE75

site_idAC5
Number of Residues8
Detailsbinding site for residue SO4 F 301
ChainResidue
FTRP204
FLEU206
FARG234
FGLN242
GTYR10
GSER11
GHIS13
GPRO14

site_idAC6
Number of Residues4
Detailsbinding site for residue SO4 F 302
ChainResidue
EARG22
EPHE74
FARG17
FGLY18

site_idAC7
Number of Residues4
Detailsbinding site for residue SO4 I 301
ChainResidue
IPRO8
ISER103
IGLY104
IARG106

site_idAC8
Number of Residues4
Detailsbinding site for residue SO4 J 301
ChainResidue
FHIS151
JASP63
JARG85
JLYS102

Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVNH
ChainResidueDetails
BTYR78-HIS84
ATYR257-HIS263

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
EASN71
FTHR143
FLYS146
FTYR171
JASN71
ATYR84
ATHR143
ALYS146
ATYR171
FTYR7
FTHR73
FTYR84

site_idSWS_FT_FI2
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498
ChainResidueDetails
EASN186
JASN186
IASN144
IASN178

site_idSWS_FT_FI3
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498
ChainResidueDetails
DASN189
GLYS58
GLYS91
GLYS94
IASN189
BLYS48
BLYS58
BLYS91
BLYS94
GLYS19
GLYS41
GLYS48

site_idSWS_FT_FI4
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
ChainResidueDetails
AASN86
FASN86

217157

PDB entries from 2024-03-13

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