5BY6
Crystal structure of Trichinella spiralis thymidylate synthase complexed with dUMP
Replaces: 4G9UFunctional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004799 | molecular_function | thymidylate synthase activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0006231 | biological_process | dTMP biosynthetic process |
| A | 0006235 | biological_process | dTTP biosynthetic process |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0009165 | biological_process | nucleotide biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| A | 0032259 | biological_process | methylation |
| B | 0004799 | molecular_function | thymidylate synthase activity |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005829 | cellular_component | cytosol |
| B | 0006231 | biological_process | dTMP biosynthetic process |
| B | 0006235 | biological_process | dTTP biosynthetic process |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0009165 | biological_process | nucleotide biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| B | 0032259 | biological_process | methylation |
| C | 0004799 | molecular_function | thymidylate synthase activity |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005829 | cellular_component | cytosol |
| C | 0006231 | biological_process | dTMP biosynthetic process |
| C | 0006235 | biological_process | dTTP biosynthetic process |
| C | 0008168 | molecular_function | methyltransferase activity |
| C | 0009165 | biological_process | nucleotide biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| C | 0032259 | biological_process | methylation |
| D | 0004799 | molecular_function | thymidylate synthase activity |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0005829 | cellular_component | cytosol |
| D | 0006231 | biological_process | dTMP biosynthetic process |
| D | 0006235 | biological_process | dTTP biosynthetic process |
| D | 0008168 | molecular_function | methyltransferase activity |
| D | 0009165 | biological_process | nucleotide biosynthetic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| D | 0032259 | biological_process | methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | binding site for residue UMP A 401 |
| Chain | Residue |
| A | ARG43 |
| A | ASN220 |
| A | HIS250 |
| A | TYR252 |
| A | HOH559 |
| A | HOH616 |
| A | HOH640 |
| B | ARG169 |
| B | ARG170 |
| A | CYS189 |
| A | HIS190 |
| A | GLN208 |
| A | ARG209 |
| A | SER210 |
| A | ALA211 |
| A | ASP212 |
| A | GLY216 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue DTT A 402 |
| Chain | Residue |
| A | GLU81 |
| A | HOH616 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 403 |
| Chain | Residue |
| A | GLY137 |
| A | ASN177 |
| A | HOH524 |
| B | ASN177 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 404 |
| Chain | Residue |
| A | CYS179 |
| B | GLY137 |
| B | GLY151 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 405 |
| Chain | Residue |
| A | ASP257 |
| A | ILE275 |
| A | LEU276 |
| A | ARG277 |
| A | ASN278 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 406 |
| Chain | Residue |
| A | TYR152 |
| A | ASP153 |
| A | GLN157 |
| A | HOH531 |
| D | ASN119 |
| site_id | AC7 |
| Number of Residues | 15 |
| Details | binding site for residue UMP B 401 |
| Chain | Residue |
| A | ARG169 |
| A | ARG170 |
| B | ARG43 |
| B | CYS189 |
| B | HIS190 |
| B | GLN208 |
| B | ARG209 |
| B | SER210 |
| B | ALA211 |
| B | ASP212 |
| B | ASN220 |
| B | HIS250 |
| B | TYR252 |
| B | HOH531 |
| B | HOH552 |
| site_id | AC8 |
| Number of Residues | 18 |
| Details | binding site for residue UMP C 401 |
| Chain | Residue |
| C | ARG43 |
| C | CYS189 |
| C | HIS190 |
| C | GLN208 |
| C | ARG209 |
| C | SER210 |
| C | ALA211 |
| C | ASP212 |
| C | GLY216 |
| C | ASN220 |
| C | HIS250 |
| C | TYR252 |
| C | HOH591 |
| C | HOH607 |
| C | HOH648 |
| C | HOH667 |
| D | ARG169 |
| D | ARG170 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue GOL C 402 |
| Chain | Residue |
| C | CYS179 |
| D | GLY137 |
| D | GLY151 |
| site_id | AD1 |
| Number of Residues | 16 |
| Details | binding site for residue UMP D 401 |
| Chain | Residue |
| C | ARG169 |
| C | ARG170 |
| D | ARG43 |
| D | CYS189 |
| D | HIS190 |
| D | GLN208 |
| D | ARG209 |
| D | SER210 |
| D | ALA211 |
| D | ASP212 |
| D | GLY216 |
| D | ASN220 |
| D | HIS250 |
| D | TYR252 |
| D | HOH591 |
| D | HOH599 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue GOL D 402 |
| Chain | Residue |
| D | GLY151 |
| D | TYR152 |
| D | ASP153 |
| D | GLN157 |
| D | HOH524 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue GOL D 403 |
| Chain | Residue |
| C | PHE136 |
| C | GLY151 |
| C | TYR152 |
| D | CYS179 |
| D | HOH553 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue GOL D 404 |
| Chain | Residue |
| D | ASN106 |
| D | HOH505 |
| D | HOH572 |
| D | ILE102 |
Functional Information from PROSITE/UniProt
| site_id | PS00091 |
| Number of Residues | 29 |
| Details | THYMIDYLATE_SYNTHASE Thymidylate synthase active site. RriImtaWNpcdlekva.....LpPCHcfvQFyV |
| Chain | Residue | Details |
| A | ARG169-VAL197 |
