5BY6
Crystal structure of Trichinella spiralis thymidylate synthase complexed with dUMP
Replaces: 4G9UFunctional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004799 | molecular_function | thymidylate synthase activity |
A | 0005739 | cellular_component | mitochondrion |
A | 0005829 | cellular_component | cytosol |
A | 0006231 | biological_process | dTMP biosynthetic process |
A | 0006235 | biological_process | dTTP biosynthetic process |
A | 0008168 | molecular_function | methyltransferase activity |
A | 0009165 | biological_process | nucleotide biosynthetic process |
A | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
A | 0032259 | biological_process | methylation |
B | 0004799 | molecular_function | thymidylate synthase activity |
B | 0005739 | cellular_component | mitochondrion |
B | 0005829 | cellular_component | cytosol |
B | 0006231 | biological_process | dTMP biosynthetic process |
B | 0006235 | biological_process | dTTP biosynthetic process |
B | 0008168 | molecular_function | methyltransferase activity |
B | 0009165 | biological_process | nucleotide biosynthetic process |
B | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
B | 0032259 | biological_process | methylation |
C | 0004799 | molecular_function | thymidylate synthase activity |
C | 0005739 | cellular_component | mitochondrion |
C | 0005829 | cellular_component | cytosol |
C | 0006231 | biological_process | dTMP biosynthetic process |
C | 0006235 | biological_process | dTTP biosynthetic process |
C | 0008168 | molecular_function | methyltransferase activity |
C | 0009165 | biological_process | nucleotide biosynthetic process |
C | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
C | 0032259 | biological_process | methylation |
D | 0004799 | molecular_function | thymidylate synthase activity |
D | 0005739 | cellular_component | mitochondrion |
D | 0005829 | cellular_component | cytosol |
D | 0006231 | biological_process | dTMP biosynthetic process |
D | 0006235 | biological_process | dTTP biosynthetic process |
D | 0008168 | molecular_function | methyltransferase activity |
D | 0009165 | biological_process | nucleotide biosynthetic process |
D | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
D | 0032259 | biological_process | methylation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 17 |
Details | binding site for residue UMP A 401 |
Chain | Residue |
A | ARG43 |
A | ASN220 |
A | HIS250 |
A | TYR252 |
A | HOH559 |
A | HOH616 |
A | HOH640 |
B | ARG169 |
B | ARG170 |
A | CYS189 |
A | HIS190 |
A | GLN208 |
A | ARG209 |
A | SER210 |
A | ALA211 |
A | ASP212 |
A | GLY216 |
site_id | AC2 |
Number of Residues | 2 |
Details | binding site for residue DTT A 402 |
Chain | Residue |
A | GLU81 |
A | HOH616 |
site_id | AC3 |
Number of Residues | 4 |
Details | binding site for residue GOL A 403 |
Chain | Residue |
A | GLY137 |
A | ASN177 |
A | HOH524 |
B | ASN177 |
site_id | AC4 |
Number of Residues | 3 |
Details | binding site for residue GOL A 404 |
Chain | Residue |
A | CYS179 |
B | GLY137 |
B | GLY151 |
site_id | AC5 |
Number of Residues | 5 |
Details | binding site for residue GOL A 405 |
Chain | Residue |
A | ASP257 |
A | ILE275 |
A | LEU276 |
A | ARG277 |
A | ASN278 |
site_id | AC6 |
Number of Residues | 5 |
Details | binding site for residue GOL A 406 |
Chain | Residue |
A | TYR152 |
A | ASP153 |
A | GLN157 |
A | HOH531 |
D | ASN119 |
site_id | AC7 |
Number of Residues | 15 |
Details | binding site for residue UMP B 401 |
Chain | Residue |
A | ARG169 |
A | ARG170 |
B | ARG43 |
B | CYS189 |
B | HIS190 |
B | GLN208 |
B | ARG209 |
B | SER210 |
B | ALA211 |
B | ASP212 |
B | ASN220 |
B | HIS250 |
B | TYR252 |
B | HOH531 |
B | HOH552 |
site_id | AC8 |
Number of Residues | 18 |
Details | binding site for residue UMP C 401 |
Chain | Residue |
C | ARG43 |
C | CYS189 |
C | HIS190 |
C | GLN208 |
C | ARG209 |
C | SER210 |
C | ALA211 |
C | ASP212 |
C | GLY216 |
C | ASN220 |
C | HIS250 |
C | TYR252 |
C | HOH591 |
C | HOH607 |
C | HOH648 |
C | HOH667 |
D | ARG169 |
D | ARG170 |
site_id | AC9 |
Number of Residues | 3 |
Details | binding site for residue GOL C 402 |
Chain | Residue |
C | CYS179 |
D | GLY137 |
D | GLY151 |
site_id | AD1 |
Number of Residues | 16 |
Details | binding site for residue UMP D 401 |
Chain | Residue |
C | ARG169 |
C | ARG170 |
D | ARG43 |
D | CYS189 |
D | HIS190 |
D | GLN208 |
D | ARG209 |
D | SER210 |
D | ALA211 |
D | ASP212 |
D | GLY216 |
D | ASN220 |
D | HIS250 |
D | TYR252 |
D | HOH591 |
D | HOH599 |
site_id | AD2 |
Number of Residues | 5 |
Details | binding site for residue GOL D 402 |
Chain | Residue |
D | GLY151 |
D | TYR152 |
D | ASP153 |
D | GLN157 |
D | HOH524 |
site_id | AD3 |
Number of Residues | 5 |
Details | binding site for residue GOL D 403 |
Chain | Residue |
C | PHE136 |
C | GLY151 |
C | TYR152 |
D | CYS179 |
D | HOH553 |
site_id | AD4 |
Number of Residues | 4 |
Details | binding site for residue GOL D 404 |
Chain | Residue |
D | ASN106 |
D | HOH505 |
D | HOH572 |
D | ILE102 |
Functional Information from PROSITE/UniProt
site_id | PS00091 |
Number of Residues | 29 |
Details | THYMIDYLATE_SYNTHASE Thymidylate synthase active site. RriImtaWNpcdlekva.....LpPCHcfvQFyV |
Chain | Residue | Details |
A | ARG169-VAL197 |