5BXV
eIF4E complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003743 | molecular_function | translation initiation factor activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006413 | biological_process | translational initiation |
| B | 0008190 | molecular_function | eukaryotic initiation factor 4E binding |
| B | 0045947 | biological_process | negative regulation of translational initiation |
| C | 0003723 | molecular_function | RNA binding |
| C | 0003743 | molecular_function | translation initiation factor activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006413 | biological_process | translational initiation |
| D | 0008190 | molecular_function | eukaryotic initiation factor 4E binding |
| D | 0045947 | biological_process | negative regulation of translational initiation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue MGP A 301 |
| Chain | Residue |
| A | TRP56 |
| A | HOH430 |
| A | HOH442 |
| A | HOH451 |
| A | HOH453 |
| A | MET101 |
| A | TRP102 |
| A | GLU103 |
| A | ARG157 |
| A | LYS162 |
| A | HOH410 |
| A | HOH417 |
| A | HOH427 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for residue MGP C 301 |
| Chain | Residue |
| C | TRP56 |
| C | GLN57 |
| C | MET101 |
| C | TRP102 |
| C | GLU103 |
| C | ARG157 |
| C | LYS162 |
| C | HOH406 |
| C | HOH410 |
| C | HOH411 |
| C | HOH413 |
| C | HOH420 |
| C | HOH465 |
Functional Information from PROSITE/UniProt
| site_id | PS00813 |
| Number of Residues | 24 |
| Details | IF4E Eukaryotic initiation factor 4E signature. DYslFKdgIePmWEDeknkrGGRW |
| Chain | Residue | Details |
| A | ASP90-TRP113 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 28 |
| Details | Region: {"description":"EIF4EBP1/2/3 binding","evidences":[{"source":"PubMed","id":"10394359","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10394359","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9200613","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | Motif: {"description":"YXXXXLphi motif","evidences":[{"source":"UniProtKB","id":"P70445","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18220336","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by DYRK2, MAPK1, MAPK3 and MTOR","evidences":[{"source":"PubMed","id":"12588975","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12747827","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22578813","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25702871","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29750193","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine; by MTOR","evidences":[{"source":"PubMed","id":"12747827","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22578813","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25702871","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29750193","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18220336","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22578813","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
