5BXV
eIF4E complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003743 | molecular_function | translation initiation factor activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006413 | biological_process | translational initiation |
| B | 0008190 | molecular_function | eukaryotic initiation factor 4E binding |
| B | 0045947 | biological_process | negative regulation of translational initiation |
| C | 0003723 | molecular_function | RNA binding |
| C | 0003743 | molecular_function | translation initiation factor activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006413 | biological_process | translational initiation |
| D | 0008190 | molecular_function | eukaryotic initiation factor 4E binding |
| D | 0045947 | biological_process | negative regulation of translational initiation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue MGP A 301 |
| Chain | Residue |
| A | TRP56 |
| A | HOH430 |
| A | HOH442 |
| A | HOH451 |
| A | HOH453 |
| A | MET101 |
| A | TRP102 |
| A | GLU103 |
| A | ARG157 |
| A | LYS162 |
| A | HOH410 |
| A | HOH417 |
| A | HOH427 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for residue MGP C 301 |
| Chain | Residue |
| C | TRP56 |
| C | GLN57 |
| C | MET101 |
| C | TRP102 |
| C | GLU103 |
| C | ARG157 |
| C | LYS162 |
| C | HOH406 |
| C | HOH410 |
| C | HOH411 |
| C | HOH413 |
| C | HOH420 |
| C | HOH465 |
Functional Information from PROSITE/UniProt
| site_id | PS00813 |
| Number of Residues | 24 |
| Details | IF4E Eukaryotic initiation factor 4E signature. DYslFKdgIePmWEDeknkrGGRW |
| Chain | Residue | Details |
| A | ASP90-TRP113 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q60876 |
| Chain | Residue | Details |
| B | SER44 | |
| D | SER44 | |
| A | ARG157 | |
| A | THR205 | |
| C | TRP56 | |
| C | TRP102 | |
| C | ARG157 | |
| C | THR205 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by MTOR => ECO:0000269|PubMed:12747827, ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:29236692, ECO:0000269|PubMed:29750193, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| B | THR46 | |
| D | THR46 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| B | THR50 | |
| D | THR50 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| B | TYR54 | |
| D | TYR54 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by DYRK2, MAPK1, MAPK3 and MTOR => ECO:0000269|PubMed:12588975, ECO:0000269|PubMed:12747827, ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:25702871, ECO:0000269|PubMed:29750193, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| B | SER65 | |
| D | SER65 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by MTOR => ECO:0000269|PubMed:12747827, ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:25702871, ECO:0000269|PubMed:29750193, ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| B | THR70 | |
| D | THR70 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| B | THR77 | |
| D | THR77 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| B | SER83 | |
| D | SER83 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:22578813 |
| Chain | Residue | Details |
| B | LYS57 | |
| D | LYS57 |
