Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006259 | biological_process | DNA metabolic process |
| A | 0006265 | biological_process | DNA topological change |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006265 | biological_process | DNA topological change |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006259 | biological_process | DNA metabolic process |
| C | 0006265 | biological_process | DNA topological change |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006265 | biological_process | DNA topological change |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 701 |
| Chain | Residue |
| B | ASP532 |
| B | ASP534 |
| B | HOH803 |
| B | HOH806 |
| B | HOH808 |
| G | HOH102 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG D 701 |
| Chain | Residue |
| D | HOH806 |
| D | HOH807 |
| D | HOH808 |
| D | ASP532 |
| D | ASP534 |
| D | HOH801 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | binding site for residue LFX E 101 |
| Chain | Residue |
| A | ALA90 |
| A | HOH603 |
| B | THR500 |
| C | ARG128 |
| E | DT10 |
| E | DG11 |
| E | MG102 |
| E | HOH202 |
| E | HOH204 |
| F | DC14 |
| F | DA15 |
| G | DT10 |
| G | DA11 |
| H | DT14 |
| H | DA15 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue MG E 102 |
| Chain | Residue |
| A | HOH603 |
| E | LFX101 |
| E | HOH202 |
| E | HOH204 |
| site_id | AC5 |
| Number of Residues | 15 |
| Details | binding site for residue LFX F 101 |
| Chain | Residue |
| A | ARG128 |
| C | ALA90 |
| C | HOH607 |
| D | THR500 |
| E | DT14 |
| E | DA15 |
| F | DT10 |
| F | DA11 |
| F | MG102 |
| F | HOH202 |
| F | HOH204 |
| G | DC14 |
| G | DA15 |
| H | DT10 |
| H | DG11 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue MG F 102 |
| Chain | Residue |
| C | HOH607 |
| F | LFX101 |
| F | HOH202 |
| F | HOH204 |
Functional Information from PROSITE/UniProt
| site_id | PS00177 |
| Number of Residues | 9 |
| Details | TOPOISOMERASE_II DNA topoisomerase II signature. VVEGDSAGG |
| Chain | Residue | Details |
| B | VAL457-GLY465 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"O-(5'-phospho-DNA)-tyrosine intermediate","evidences":[{"source":"HAMAP-Rule","id":"MF_01897","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 228 |
| Details | Domain: {"description":"Toprim","evidences":[{"source":"HAMAP-Rule","id":"MF_01898","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01898","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Site: {"description":"Interaction with DNA","evidences":[{"source":"HAMAP-Rule","id":"MF_01898","evidenceCode":"ECO:0000255"}]} |
