5BPU

Crystal structure of Norrin, a Wnt signalling activator, Crystal Form I

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005109	molecular_function	frizzled binding
A	0005125	molecular_function	cytokine activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0007033	biological_process	vacuole organization
A	0007399	biological_process	nervous system development
A	0007601	biological_process	visual perception
A	0009986	cellular_component	cell surface
A	0016055	biological_process	Wnt signaling pathway
A	0035426	biological_process	extracellular matrix-cell signaling
A	0042803	molecular_function	protein homodimerization activity
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046697	biological_process	decidualization
A	0110135	biological_process	Norrin signaling pathway
B	0005109	molecular_function	frizzled binding
B	0005125	molecular_function	cytokine activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0007033	biological_process	vacuole organization
B	0007399	biological_process	nervous system development
B	0007601	biological_process	visual perception
B	0009986	cellular_component	cell surface
B	0016055	biological_process	Wnt signaling pathway
B	0035426	biological_process	extracellular matrix-cell signaling
B	0042803	molecular_function	protein homodimerization activity
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0046697	biological_process	decidualization
B	0110135	biological_process	Norrin signaling pathway
C	0005109	molecular_function	frizzled binding
C	0005125	molecular_function	cytokine activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0007033	biological_process	vacuole organization
C	0007399	biological_process	nervous system development
C	0007601	biological_process	visual perception
C	0009986	cellular_component	cell surface
C	0016055	biological_process	Wnt signaling pathway
C	0035426	biological_process	extracellular matrix-cell signaling
C	0042803	molecular_function	protein homodimerization activity
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0046697	biological_process	decidualization
C	0110135	biological_process	Norrin signaling pathway
D	0005109	molecular_function	frizzled binding
D	0005125	molecular_function	cytokine activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0007033	biological_process	vacuole organization
D	0007399	biological_process	nervous system development
D	0007601	biological_process	visual perception
D	0009986	cellular_component	cell surface
D	0016055	biological_process	Wnt signaling pathway
D	0035426	biological_process	extracellular matrix-cell signaling
D	0042803	molecular_function	protein homodimerization activity
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0046697	biological_process	decidualization
D	0110135	biological_process	Norrin signaling pathway
E	0005109	molecular_function	frizzled binding
E	0005125	molecular_function	cytokine activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0007033	biological_process	vacuole organization
E	0007399	biological_process	nervous system development
E	0007601	biological_process	visual perception
E	0009986	cellular_component	cell surface
E	0016055	biological_process	Wnt signaling pathway
E	0035426	biological_process	extracellular matrix-cell signaling
E	0042803	molecular_function	protein homodimerization activity
E	0045893	biological_process	positive regulation of DNA-templated transcription
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0046697	biological_process	decidualization
E	0110135	biological_process	Norrin signaling pathway
F	0005109	molecular_function	frizzled binding
F	0005125	molecular_function	cytokine activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0007033	biological_process	vacuole organization
F	0007399	biological_process	nervous system development
F	0007601	biological_process	visual perception
F	0009986	cellular_component	cell surface
F	0016055	biological_process	Wnt signaling pathway
F	0035426	biological_process	extracellular matrix-cell signaling
F	0042803	molecular_function	protein homodimerization activity
F	0045893	biological_process	positive regulation of DNA-templated transcription
F	0045944	biological_process	positive regulation of transcription by RNA polymerase II
F	0046697	biological_process	decidualization
F	0110135	biological_process	Norrin signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS01185
Number of Residues	37
Details	CTCK_1 C-terminal cystine knot signature. CCrpqtsklkalrlrCsgGmrltatyryilsChCee..C

Chain	Residue	Details
A	CYS95-CYS131

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	558
Details	Domain: {"description":"CTCK","evidences":[{"source":"PROSITE-ProRule","id":"PRU00039","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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