5B2G

Crystal structure of human claudin-4 in complex with C-terminal fragment of Clostridium perfringens enterotoxin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003796	molecular_function	lysozyme activity
A	0003824	molecular_function	catalytic activity
A	0005198	molecular_function	structural molecule activity
A	0005923	cellular_component	bicellular tight junction
A	0009253	biological_process	peptidoglycan catabolic process
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0016998	biological_process	cell wall macromolecule catabolic process
A	0030430	cellular_component	host cell cytoplasm
A	0031640	biological_process	killing of cells of another organism
A	0042742	biological_process	defense response to bacterium
A	0044659	biological_process	viral release from host cell by cytolysis
B	0005576	cellular_component	extracellular region
C	0003796	molecular_function	lysozyme activity
C	0003824	molecular_function	catalytic activity
C	0005198	molecular_function	structural molecule activity
C	0005923	cellular_component	bicellular tight junction
C	0009253	biological_process	peptidoglycan catabolic process
C	0016020	cellular_component	membrane
C	0016787	molecular_function	hydrolase activity
C	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
C	0016998	biological_process	cell wall macromolecule catabolic process
C	0030430	cellular_component	host cell cytoplasm
C	0031640	biological_process	killing of cells of another organism
C	0042742	biological_process	defense response to bacterium
C	0044659	biological_process	viral release from host cell by cytolysis
D	0005576	cellular_component	extracellular region
E	0003796	molecular_function	lysozyme activity
E	0003824	molecular_function	catalytic activity
E	0005198	molecular_function	structural molecule activity
E	0005923	cellular_component	bicellular tight junction
E	0009253	biological_process	peptidoglycan catabolic process
E	0016020	cellular_component	membrane
E	0016787	molecular_function	hydrolase activity
E	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
E	0016998	biological_process	cell wall macromolecule catabolic process
E	0030430	cellular_component	host cell cytoplasm
E	0031640	biological_process	killing of cells of another organism
E	0042742	biological_process	defense response to bacterium
E	0044659	biological_process	viral release from host cell by cytolysis
F	0005576	cellular_component	extracellular region
G	0003796	molecular_function	lysozyme activity
G	0003824	molecular_function	catalytic activity
G	0005198	molecular_function	structural molecule activity
G	0005923	cellular_component	bicellular tight junction
G	0009253	biological_process	peptidoglycan catabolic process
G	0016020	cellular_component	membrane
G	0016787	molecular_function	hydrolase activity
G	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
G	0016998	biological_process	cell wall macromolecule catabolic process
G	0030430	cellular_component	host cell cytoplasm
G	0031640	biological_process	killing of cells of another organism
G	0042742	biological_process	defense response to bacterium
G	0044659	biological_process	viral release from host cell by cytolysis
H	0005576	cellular_component	extracellular region

Functional Information from PROSITE/UniProt

site_id	PS01346
Number of Residues	16
Details	CLAUDIN Claudin family signature. GLWmnCvvqstgqm.QC

Chain	Residue	Details
A	GLY1212-CYS1227

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	260
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	292
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	26
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	102
Details	Region: {"description":"Interaction with EPHA2","evidences":[{"source":"PubMed","id":"16236711","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_04110","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"3382407","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7831309","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8266098","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_04110","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1892846","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3382407","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7831309","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8266098","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"8266098","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"7831309","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	2
Details	M-CSA 921

Chain	Residue	Details
A	GLU1011	proton shuttle (general acid/base)
A	ASP1020	covalent catalysis

---

site_id	MCSA2
Number of Residues	2
Details	M-CSA 921

Chain	Residue	Details
C	GLU1011	proton shuttle (general acid/base)
C	ASP1020	covalent catalysis

---

site_id	MCSA3
Number of Residues	2
Details	M-CSA 921

Chain	Residue	Details
E	GLU1011	proton shuttle (general acid/base)
E	ASP1020	covalent catalysis

---

site_id	MCSA4
Number of Residues	2
Details	M-CSA 921

Chain	Residue	Details
G	GLU1011	proton shuttle (general acid/base)
G	ASP1020	covalent catalysis

---