5AYZ

CRYSTAL STRUCTURE OF HUMAN QUINOLINATE PHOSPHORIBOSYLTRANSFERASE IN COMPLEX WITH THE PRODUCT NICOTINATE MONONUCLEOTIDE

Replaces:  4R3Y

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0009435	biological_process	NAD+ biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0016763	molecular_function	pentosyltransferase activity
A	0019363	biological_process	pyridine nucleotide biosynthetic process
A	0019674	biological_process	NAD+ metabolic process
A	0034213	biological_process	quinolinate catabolic process
A	0034354	biological_process	'de novo' NAD+ biosynthetic process from L-tryptophan
A	0042802	molecular_function	identical protein binding
A	0046874	biological_process	quinolinate metabolic process
A	0070062	cellular_component	extracellular exosome
A	1902494	cellular_component	catalytic complex
B	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0009435	biological_process	NAD+ biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016757	molecular_function	glycosyltransferase activity
B	0016763	molecular_function	pentosyltransferase activity
B	0019363	biological_process	pyridine nucleotide biosynthetic process
B	0019674	biological_process	NAD+ metabolic process
B	0034213	biological_process	quinolinate catabolic process
B	0034354	biological_process	'de novo' NAD+ biosynthetic process from L-tryptophan
B	0042802	molecular_function	identical protein binding
B	0046874	biological_process	quinolinate metabolic process
B	0070062	cellular_component	extracellular exosome
B	1902494	cellular_component	catalytic complex
C	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0009435	biological_process	NAD+ biosynthetic process
C	0016740	molecular_function	transferase activity
C	0016757	molecular_function	glycosyltransferase activity
C	0016763	molecular_function	pentosyltransferase activity
C	0019363	biological_process	pyridine nucleotide biosynthetic process
C	0019674	biological_process	NAD+ metabolic process
C	0034213	biological_process	quinolinate catabolic process
C	0034354	biological_process	'de novo' NAD+ biosynthetic process from L-tryptophan
C	0042802	molecular_function	identical protein binding
C	0046874	biological_process	quinolinate metabolic process
C	0070062	cellular_component	extracellular exosome
C	1902494	cellular_component	catalytic complex
D	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0009435	biological_process	NAD+ biosynthetic process
D	0016740	molecular_function	transferase activity
D	0016757	molecular_function	glycosyltransferase activity
D	0016763	molecular_function	pentosyltransferase activity
D	0019363	biological_process	pyridine nucleotide biosynthetic process
D	0019674	biological_process	NAD+ metabolic process
D	0034213	biological_process	quinolinate catabolic process
D	0034354	biological_process	'de novo' NAD+ biosynthetic process from L-tryptophan
D	0042802	molecular_function	identical protein binding
D	0046874	biological_process	quinolinate metabolic process
D	0070062	cellular_component	extracellular exosome
D	1902494	cellular_component	catalytic complex
E	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0009435	biological_process	NAD+ biosynthetic process
E	0016740	molecular_function	transferase activity
E	0016757	molecular_function	glycosyltransferase activity
E	0016763	molecular_function	pentosyltransferase activity
E	0019363	biological_process	pyridine nucleotide biosynthetic process
E	0019674	biological_process	NAD+ metabolic process
E	0034213	biological_process	quinolinate catabolic process
E	0034354	biological_process	'de novo' NAD+ biosynthetic process from L-tryptophan
E	0042802	molecular_function	identical protein binding
E	0046874	biological_process	quinolinate metabolic process
E	0070062	cellular_component	extracellular exosome
E	1902494	cellular_component	catalytic complex
F	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0009435	biological_process	NAD+ biosynthetic process
F	0016740	molecular_function	transferase activity
F	0016757	molecular_function	glycosyltransferase activity
F	0016763	molecular_function	pentosyltransferase activity
F	0019363	biological_process	pyridine nucleotide biosynthetic process
F	0019674	biological_process	NAD+ metabolic process
F	0034213	biological_process	quinolinate catabolic process
F	0034354	biological_process	'de novo' NAD+ biosynthetic process from L-tryptophan
F	0042802	molecular_function	identical protein binding
F	0046874	biological_process	quinolinate metabolic process
F	0070062	cellular_component	extracellular exosome
F	1902494	cellular_component	catalytic complex
G	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0009435	biological_process	NAD+ biosynthetic process
G	0016740	molecular_function	transferase activity
G	0016757	molecular_function	glycosyltransferase activity
G	0016763	molecular_function	pentosyltransferase activity
G	0019363	biological_process	pyridine nucleotide biosynthetic process
G	0019674	biological_process	NAD+ metabolic process
G	0034213	biological_process	quinolinate catabolic process
G	0034354	biological_process	'de novo' NAD+ biosynthetic process from L-tryptophan
G	0042802	molecular_function	identical protein binding
G	0046874	biological_process	quinolinate metabolic process
G	0070062	cellular_component	extracellular exosome
G	1902494	cellular_component	catalytic complex
H	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0009435	biological_process	NAD+ biosynthetic process
H	0016740	molecular_function	transferase activity
H	0016757	molecular_function	glycosyltransferase activity
H	0016763	molecular_function	pentosyltransferase activity
H	0019363	biological_process	pyridine nucleotide biosynthetic process
H	0019674	biological_process	NAD+ metabolic process
H	0034213	biological_process	quinolinate catabolic process
H	0034354	biological_process	'de novo' NAD+ biosynthetic process from L-tryptophan
H	0042802	molecular_function	identical protein binding
H	0046874	biological_process	quinolinate metabolic process
H	0070062	cellular_component	extracellular exosome
H	1902494	cellular_component	catalytic complex
I	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0009435	biological_process	NAD+ biosynthetic process
I	0016740	molecular_function	transferase activity
I	0016757	molecular_function	glycosyltransferase activity
I	0016763	molecular_function	pentosyltransferase activity
I	0019363	biological_process	pyridine nucleotide biosynthetic process
I	0019674	biological_process	NAD+ metabolic process
I	0034213	biological_process	quinolinate catabolic process
I	0034354	biological_process	'de novo' NAD+ biosynthetic process from L-tryptophan
I	0042802	molecular_function	identical protein binding
I	0046874	biological_process	quinolinate metabolic process
I	0070062	cellular_component	extracellular exosome
I	1902494	cellular_component	catalytic complex
J	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0009435	biological_process	NAD+ biosynthetic process
J	0016740	molecular_function	transferase activity
J	0016757	molecular_function	glycosyltransferase activity
J	0016763	molecular_function	pentosyltransferase activity
J	0019363	biological_process	pyridine nucleotide biosynthetic process
J	0019674	biological_process	NAD+ metabolic process
J	0034213	biological_process	quinolinate catabolic process
J	0034354	biological_process	'de novo' NAD+ biosynthetic process from L-tryptophan
J	0042802	molecular_function	identical protein binding
J	0046874	biological_process	quinolinate metabolic process
J	0070062	cellular_component	extracellular exosome
J	1902494	cellular_component	catalytic complex
K	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0009435	biological_process	NAD+ biosynthetic process
K	0016740	molecular_function	transferase activity
K	0016757	molecular_function	glycosyltransferase activity
K	0016763	molecular_function	pentosyltransferase activity
K	0019363	biological_process	pyridine nucleotide biosynthetic process
K	0019674	biological_process	NAD+ metabolic process
K	0034213	biological_process	quinolinate catabolic process
K	0034354	biological_process	'de novo' NAD+ biosynthetic process from L-tryptophan
K	0042802	molecular_function	identical protein binding
K	0046874	biological_process	quinolinate metabolic process
K	0070062	cellular_component	extracellular exosome
K	1902494	cellular_component	catalytic complex
L	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0009435	biological_process	NAD+ biosynthetic process
L	0016740	molecular_function	transferase activity
L	0016757	molecular_function	glycosyltransferase activity
L	0016763	molecular_function	pentosyltransferase activity
L	0019363	biological_process	pyridine nucleotide biosynthetic process
L	0019674	biological_process	NAD+ metabolic process
L	0034213	biological_process	quinolinate catabolic process
L	0034354	biological_process	'de novo' NAD+ biosynthetic process from L-tryptophan
L	0042802	molecular_function	identical protein binding
L	0046874	biological_process	quinolinate metabolic process
L	0070062	cellular_component	extracellular exosome
L	1902494	cellular_component	catalytic complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue NCN A 401

Chain	Residue
A	ARG138
A	SER248
A	GLY250
A	SER268
A	MET269
A	GLY270
A	HOH510
A	HOH511
A	HOH519
A	HOH522
A	LYS139
A	HIS160
A	ARG161
A	MET169
A	LYS171
A	GLU201
A	ASP222
A	GLU246

---

site_id	AC2
Number of Residues	17
Details	binding site for residue NCN B 401

Chain	Residue
B	ARG138
B	LYS139
B	HIS160
B	ARG161
B	MET169
B	LYS171
B	GLU201
B	ASP222
B	GLU246
B	SER248
B	GLY249
B	GLY250
B	SER268
B	GLY270
B	HOH502
B	HOH507
B	HOH513

---

site_id	AC3
Number of Residues	17
Details	binding site for residue NCN C 401

Chain	Residue
C	ARG138
C	LYS139
C	HIS160
C	ARG161
C	MET169
C	LYS171
C	ASP222
C	SER248
C	GLY249
C	GLY250
C	SER268
C	GLY270
C	HOH507
C	HOH509
C	HOH510
C	HOH514
C	HOH517

---

site_id	AC4
Number of Residues	16
Details	binding site for residue NCN D 401

Chain	Residue
D	ARG138
D	LYS139
D	HIS160
D	ARG161
D	MET169
D	LYS171
D	GLU201
D	ASP222
D	GLU246
D	SER248
D	GLY249
D	GLY250
D	SER268
D	GLY270
D	HOH505
D	HOH506

---

site_id	AC5
Number of Residues	16
Details	binding site for residue NCN E 401

Chain	Residue
E	ARG138
E	LYS139
E	HIS160
E	ARG161
E	MET169
E	LYS171
E	GLU201
E	ASP222
E	GLU246
E	SER248
E	GLY250
E	SER268
E	GLY270
E	HOH501
E	HOH505
E	HOH510

---

site_id	AC6
Number of Residues	14
Details	binding site for residue NCN F 401

Chain	Residue
F	THR137
F	ARG138
F	LYS139
F	HIS160
F	ARG161
F	MET169
F	LYS171
F	GLU201
F	ASP222
F	SER248
F	GLY250
F	MET269
F	GLY270
F	HOH503

---

site_id	AC7
Number of Residues	17
Details	binding site for residue NCN G 401

Chain	Residue
G	LYS139
G	HIS160
G	ARG161
G	MET169
G	LYS171
G	GLU201
G	ASP222
G	GLU246
G	SER248
G	GLY249
G	GLY250
G	SER268
G	MET269
G	GLY270
G	HOH509
G	HOH519
G	ARG138

---

site_id	AC8
Number of Residues	18
Details	binding site for residue NCN H 401

Chain	Residue
H	ARG138
H	LYS139
H	HIS160
H	ARG161
H	MET169
H	LYS171
H	GLU201
H	ASP222
H	GLU246
H	SER248
H	GLY249
H	GLY250
H	SER268
H	GLY270
H	HOH502
H	HOH504
H	HOH513
H	HOH515

---

site_id	AC9
Number of Residues	15
Details	binding site for residue NCN I 401

Chain	Residue
I	ARG138
I	LYS139
I	HIS160
I	ARG161
I	MET169
I	LYS171
I	ASP222
I	SER248
I	GLY249
I	GLY250
I	SER268
I	GLY270
I	HOH506
I	HOH507
I	HOH516

---

site_id	AD1
Number of Residues	16
Details	binding site for residue NCN J 401

Chain	Residue
J	ARG138
J	LYS139
J	HIS160
J	ARG161
J	MET169
J	LYS171
J	GLU201
J	ASP222
J	GLU246
J	SER248
J	GLY249
J	GLY250
J	SER268
J	GLY270
J	HOH503
J	HOH506

---

site_id	AD2
Number of Residues	15
Details	binding site for residue NCN K 401

Chain	Residue
K	ARG138
K	LYS139
K	HIS160
K	ARG161
K	MET169
K	LYS171
K	GLU201
K	ASP222
K	SER248
K	GLY250
K	SER268
K	GLY270
K	HOH502
K	HOH506
K	HOH507

---

site_id	AD3
Number of Residues	13
Details	binding site for residue NCN L 401

Chain	Residue
L	THR137
L	ARG138
L	LYS139
L	HIS160
L	ARG161
L	LYS171
L	GLU201
L	ASP222
L	SER248
L	GLY250
L	GLY270
L	HOH502
L	HOH511

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	Region: {"description":"Important for hexamer formation","evidences":[{"source":"PubMed","id":"26805589","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26805589","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17868694","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24038671","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2JBM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KWW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AYY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AYZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26805589","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5AYZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---