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5AWM

The Crystal Structure of JNK from Drosophila melanogaster Reveals an Evolutionarily Conserved Topology with that of Mammalian JNK Proteins.

Replaces:  4M3A
Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004705molecular_functionJUN kinase activity
A0004707molecular_functionMAP kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006468biological_processprotein phosphorylation
A0006979biological_processresponse to oxidative stress
A0007154biological_processcell communication
A0007254biological_processJNK cascade
A0007391biological_processdorsal closure
A0007395biological_processdorsal closure, spreading of leading edge cells
A0007411biological_processaxon guidance
A0007616biological_processlong-term memory
A0008284biological_processpositive regulation of cell population proliferation
A0009267biological_processcellular response to starvation
A0009408biological_processresponse to heat
A0009605biological_processresponse to external stimulus
A0010508biological_processpositive regulation of autophagy
A0010628biological_processpositive regulation of gene expression
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0016319biological_processmushroom body development
A0016740molecular_functiontransferase activity
A0019731biological_processantibacterial humoral response
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0030707biological_processfollicle cell of egg chamber development
A0033209biological_processtumor necrosis factor-mediated signaling pathway
A0033554biological_processcellular response to stress
A0034599biological_processcellular response to oxidative stress
A0034614biological_processcellular response to reactive oxygen species
A0035006biological_processmelanization defense response
A0035313biological_processwound healing, spreading of epidermal cells
A0042060biological_processwound healing
A0043065biological_processpositive regulation of apoptotic process
A0043068biological_processpositive regulation of programmed cell death
A0043652biological_processengulfment of apoptotic cell
A0046529biological_processimaginal disc fusion, thorax closure
A0046843biological_processdorsal appendage formation
A0046844biological_processchorion micropyle formation
A0048010biological_processvascular endothelial growth factor receptor signaling pathway
A0048615biological_processembryonic anterior midgut (ectodermal) morphogenesis
A0048666biological_processneuron development
A0048674biological_processcollateral sprouting of injured axon
A0048675biological_processaxon extension
A0048803biological_processimaginal disc-derived male genitalia morphogenesis
A0048812biological_processneuron projection morphogenesis
A0050829biological_processdefense response to Gram-negative bacterium
A0061057biological_processpeptidoglycan recognition protein signaling pathway
A0071243biological_processcellular response to arsenic-containing substance
A0071276biological_processcellular response to cadmium ion
A0071907biological_processdetermination of digestive tract left/right asymmetry
A0106310molecular_functionprotein serine kinase activity
A0140255biological_processregulation of cellular response to phosphate starvation
A1903688biological_processpositive regulation of border follicle cell migration
A1904801biological_processpositive regulation of neuron remodeling
Functional Information from PDB Data
site_idAC1
Number of Residues22
Detailsbinding site for residue ANP A 401
ChainResidue
AILE30
AASN112
ASER153
AASN154
AMG402
AMG403
AHOH527
AHOH532
AHOH538
AHOH542
AHOH543
AGLY31
AHOH561
AHOH570
AHOH605
AILE37
AVAL38
AALA51
ALYS53
AMET106
AGLU107
AMET109

site_idAC2
Number of Residues4
Detailsbinding site for residue MG A 402
ChainResidue
AASN154
AANP401
AHOH538
AHOH542

site_idAC3
Number of Residues5
Detailsbinding site for residue MG A 403
ChainResidue
AGLU71
AANP401
AHOH532
AHOH570
AHOH581

Functional Information from PROSITE/UniProt
site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKpsNIVV
ChainResidueDetails
AILE145-VAL157

site_idPS01351
Number of Residues103
DetailsMAPK MAP kinase signature. FqnvthakrayREfklmklvnhkniigllnaftpqrnleefqdvylvmelmdanlcqviqmdldhdrmsyllyqmlcgikhlhsagiih..........RDlKpsnivvkadC
ChainResidueDetails
APHE59-CYS161

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
ChainResidueDetails
AASP149

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
AGLY31
ALYS53

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:18456458
ChainResidueDetails
ATHR181

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000269|PubMed:18456458
ChainResidueDetails
ATYR183

218196

PDB entries from 2024-04-10

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