5AER

Neuronal calcium sensor-1 (NCS-1)from Rattus norvegicus complex with D2 dopamine receptor peptide from Homo sapiens

Replaces:  2YOU

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0005245	molecular_function	voltage-gated calcium channel activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005794	cellular_component	Golgi apparatus
A	0005886	cellular_component	plasma membrane
A	0008048	molecular_function	calcium sensitive guanylate cyclase activator activity
A	0008427	molecular_function	calcium-dependent protein kinase inhibitor activity
A	0010975	biological_process	regulation of neuron projection development
A	0014069	cellular_component	postsynaptic density
A	0019901	molecular_function	protein kinase binding
A	0030424	cellular_component	axon
A	0030425	cellular_component	dendrite
A	0031045	cellular_component	dense core granule
A	0044305	cellular_component	calyx of Held
A	0045202	cellular_component	synapse
A	0045921	biological_process	positive regulation of exocytosis
A	0046872	molecular_function	metal ion binding
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0050850	biological_process	positive regulation of calcium-mediated signaling
A	0070588	biological_process	calcium ion transmembrane transport
A	0098794	cellular_component	postsynapse
A	0098978	cellular_component	glutamatergic synapse
A	0099509	biological_process	regulation of presynaptic cytosolic calcium ion concentration
A	0099523	cellular_component	presynaptic cytosol
A	0099524	cellular_component	postsynaptic cytosol
A	2000300	biological_process	regulation of synaptic vesicle exocytosis

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 200

Chain	Residue
A	ASP73
A	ASN75
A	ASP77
A	ARG79
A	GLU81
A	GLU84

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 201

Chain	Residue
A	TYR115
A	GLU120
A	ASP109
A	ASP111
A	ASP113

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site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 202

Chain	Residue
A	ASP157
A	ASN159
A	ASP161
A	LYS163
A	GLU168

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site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE K A 203

Chain	Residue
A	HOH2015

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Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DENKDGRIEfsEF

Chain	Residue	Details
A	ASP73-PHE85
A	ASP109-MET121
A	ASP157-PHE169

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	22
Details	TOPO_DOM: Cytoplasmic => ECO:0000250

Chain	Residue	Details
B	GLU432-SER443
C	GLU432-SER443
A	ASP77
A	ARG79
A	GLU84

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site_id	SWS_FT_FI2
Number of Residues	2
Details	LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:26535572

Chain	Residue	Details
B	SER443
C	SER443

---

site_id	SWS_FT_FI3
Number of Residues	5
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:25979333, ECO:0007744|PDB:4OV2, ECO:0007744|PDB:4YRU, ECO:0007744|PDB:5AEQ

Chain	Residue	Details
A	ASP109
A	ASP111
A	ASP113
A	TYR115
A	GLU120

---

site_id	SWS_FT_FI4
Number of Residues	5
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:25979333, ECO:0007744|PDB:4OV2, ECO:0007744|PDB:4YRU, ECO:0007744|PDB:5AEQ, ECO:0007744|PDB:5AER, ECO:0007744|PDB:5AFP

Chain	Residue	Details
A	ASP157
A	ASN159
A	ASP161
A	LYS163
A	GLU168

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	LIPID: N-myristoyl glycine => ECO:0000269|PubMed:10514519

Chain	Residue	Details
A	GLY2

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