5AER

Neuronal calcium sensor-1 (NCS-1)from Rattus norvegicus complex with D2 dopamine receptor peptide from Homo sapiens

Replaces:  2YOU

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0005245	molecular_function	voltage-gated calcium channel activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005794	cellular_component	Golgi apparatus
A	0005886	cellular_component	plasma membrane
A	0008048	molecular_function	calcium sensitive guanylate cyclase activator activity
A	0008427	molecular_function	calcium-dependent protein kinase inhibitor activity
A	0009966	biological_process	regulation of signal transduction
A	0010975	biological_process	regulation of neuron projection development
A	0014069	cellular_component	postsynaptic density
A	0016020	cellular_component	membrane
A	0019901	molecular_function	protein kinase binding
A	0030424	cellular_component	axon
A	0030425	cellular_component	dendrite
A	0031045	cellular_component	dense core granule
A	0044305	cellular_component	calyx of Held
A	0045921	biological_process	positive regulation of exocytosis
A	0046872	molecular_function	metal ion binding
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0050850	biological_process	positive regulation of calcium-mediated signaling
A	0070588	biological_process	calcium ion transmembrane transport
A	0098794	cellular_component	postsynapse
A	0098978	cellular_component	glutamatergic synapse
A	0099509	biological_process	regulation of presynaptic cytosolic calcium ion concentration
A	0099523	cellular_component	presynaptic cytosol
A	0099524	cellular_component	postsynaptic cytosol
A	2000300	biological_process	regulation of synaptic vesicle exocytosis

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 200

Chain	Residue
A	ASP73
A	ASN75
A	ASP77
A	ARG79
A	GLU81
A	GLU84

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 201

Chain	Residue
A	TYR115
A	GLU120
A	ASP109
A	ASP111
A	ASP113

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 202

Chain	Residue
A	ASP157
A	ASN159
A	ASP161
A	LYS163
A	GLU168

---

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE K A 203

Chain	Residue
A	HOH2015

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DENKDGRIEfsEF

Chain	Residue	Details
A	ASP73-PHE85
A	ASP109-MET121
A	ASP157-PHE169

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	35
Details	Domain: {"description":"EF-hand 1","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	35
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	35
Details	Domain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	35
Details	Domain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	11
Details	Region: {"description":"Ancestral calcium site 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	16
Details	Region: {"description":"Interaction with IL1RAPL1","evidences":[{"source":"UniProtKB","id":"P62166","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25979333","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4OV2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YRU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AEQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AER","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25979333","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4YRU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AEQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AER","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25979333","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4OV2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YRU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AEQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25979333","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4OV2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YRU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AEQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AER","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AFP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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