Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5A3Q

Crystal structure of the (SR) Calcium ATPase E2-vanadate complex bound to thapsigargin and TNP-AMPPCP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005215	molecular_function	transporter activity
A	0005388	molecular_function	P-type calcium transporter activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006811	biological_process	monoatomic ion transport
A	0006816	biological_process	calcium ion transport
A	0016020	cellular_component	membrane
A	0016529	cellular_component	sarcoplasmic reticulum
A	0016887	molecular_function	ATP hydrolysis activity
A	0031448	biological_process	positive regulation of fast-twitch skeletal muscle fiber contraction
A	0033017	cellular_component	sarcoplasmic reticulum membrane
A	0046872	molecular_function	metal ion binding
A	0070588	biological_process	calcium ion transmembrane transport
A	0106134	biological_process	positive regulation of cardiac muscle cell contraction
A	1901896	biological_process	positive regulation of ATPase-coupled calcium transmembrane transporter activity
A	1902082	biological_process	positive regulation of calcium ion import into sarcoplasmic reticulum
A	1990036	biological_process	calcium ion import into sarcoplasmic reticulum

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE TG1 A 1000

Chain	Residue
A	LYS252
A	ILE829
A	PHE834
A	TYR837
A	GLU255
A	PHE256
A	GLN259
A	LEU260
A	ILE765
A	VAL769
A	VAL772
A	VAL773

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE VN4 A 1001

Chain	Residue
A	THR181
A	GLY182
A	ASP351
A	LYS352
A	THR353
A	THR625
A	GLY626
A	LYS684
A	ASN706
A	MG1003
A	HOH2001
A	HOH2002
A	HOH2003

site_id	AC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE DL5 A 1002

Chain	Residue
A	VAL185
A	SER186
A	ILE188
A	LYS205
A	MET361
A	THR441
A	PHE487
A	SER493
A	MET494
A	LYS515
A	GLY516
A	ALA517
A	ARG560
A	ASN628
A	MG1004
A	HOH2004
A	HOH2007

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 1003

Chain	Residue
A	ASP351
A	THR353
A	ASP703
A	VN41001
A	HOH2002
A	HOH2003

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 1004

Chain	Residue
A	ASN628
A	DL51002
A	HOH2004

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K A 1008

Chain	Residue
A	GLN244
A	LEU711
A	LYS712
A	ALA714
A	GLY717
A	GLU732

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 1009

Chain	Residue
A	LYS629
A	ARG678

Functional Information from PROSITE/UniProt

site_id	PS00154
Number of Residues	7
Details	ATPASE_E1_E2 E1-E2 ATPases phosphorylation site. DKTGTLT

Chain	Residue	Details
A	ASP351-THR357

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	663
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	108
Details	Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	17
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	20
Details	Region: {"description":"Interaction with PLN","evidences":[{"source":"PubMed","id":"10551848","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23996003","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	11
Details	Region: {"description":"Interaction with PLN","evidences":[{"source":"PubMed","id":"23996003","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	1
Details	Active site: {"description":"4-aspartylphosphate intermediate","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18075584","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C9M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NAB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C9M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WPG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XP5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B9B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FGO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FPB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N5K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BEW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5A3Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5A3S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BY4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2DQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UU1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WPG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2DQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FGO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FPB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BEW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BY4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C8K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UU1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BY4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C8K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2DQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H1W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UU1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UU1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FGO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FPB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BEW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI30
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI31
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C9M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NAB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI32
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C9M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI33
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI34
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C9M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NAB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI35
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C9M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NAB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI36
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q64578","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI37
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q64578","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	3
Details	M-CSA 849

Chain	Residue	Details
A	THR355	covalent catalysis
A	ASP707	metal ligand
A	LEU711	metal ligand

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)