5A3A

Crystal structure of the ADP-ribosylating sirtuin (SirTM) from Streptococcus pyogenes (Apo form)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006471	biological_process	obsolete protein ADP-ribosylation
A	0008270	molecular_function	zinc ion binding
A	0016740	molecular_function	transferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0046872	molecular_function	metal ion binding
A	0070403	molecular_function	NAD+ binding
A	0140806	molecular_function	NAD+-protein-aspartate ADP-ribosyltransferase activity
A	1990404	molecular_function	NAD+-protein mono-ADP-ribosyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1293

Chain	Residue
A	CYS145
A	CYS149
A	CYS180
A	CYS183

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GLY A 1294

Chain	Residue
A	EDO1304
A	HOH2280
A	HOH2281
A	TYR60
A	GLN61
A	GLN67
A	PHE71
A	VAL125

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GLY A 1295

Chain	Residue
A	THR153
A	TYR154
A	LYS155

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GLY A 1296

Chain	Residue
A	GLU200
A	PHE204
A	LYS208
A	HOH2197

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GLY A 1297

Chain	Residue
A	HIS259
A	LYS260
A	GLN291
A	HOH2249

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GLY A 1298

Chain	Residue
A	TRP243
A	ARG263
A	EDO1302

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1299

Chain	Residue
A	TYR44
A	ASN118
A	ALA119
A	ASP120
A	TYR140
A	EDO1303

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1300

Chain	Residue
A	ASP72
A	PHE73
A	ASP75
A	HOH2284
A	HOH2285

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1301

Chain	Residue
A	ALA88
A	LEU89
A	ASP93
A	HOH2089
A	HOH2286

---

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 1302

Chain	Residue
A	ASP26
A	LYS110
A	ASP111
A	ARG263
A	GLY1298
A	HOH2017
A	HOH2254

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 1303

Chain	Residue
A	THR117
A	EDO1299
A	HOH2025

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1304

Chain	Residue
A	GLN67
A	TRP124
A	GLY127
A	TYR128
A	GLY1294
A	HOH2065

---

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 1305

Chain	Residue
A	ASP129
A	ASN132
A	GLU194

---