4ZVF
Crystal structure of GGDEF domain of the E. coli DosC - form II (GTP-alpha-S-bound)
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | binding site for residue GAV A 501 |
| Chain | Residue |
| A | ASP333 |
| A | LEU353 |
| A | ARG372 |
| A | GLY375 |
| A | ASP376 |
| A | LYS446 |
| A | ARG450 |
| A | CA502 |
| A | HOH618 |
| A | HOH620 |
| A | HOH624 |
| A | VAL334 |
| A | HOH693 |
| A | HOH703 |
| A | HOH716 |
| A | ASP335 |
| A | LYS336 |
| A | PHE337 |
| A | LYS338 |
| A | ASN341 |
| A | HIS346 |
| A | ASP350 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 502 |
| Chain | Residue |
| A | ASP333 |
| A | VAL334 |
| A | ASP376 |
| A | GAV501 |
| A | HOH627 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue CA A 503 |
| Chain | Residue |
| A | ASP333 |
| A | GLU377 |
| A | HOH618 |
| A | HOH627 |
| A | HOH726 |
| A | HOH732 |
| A | HOH736 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 504 |
| Chain | Residue |
| A | ASP335 |
| A | ILE340 |
| A | ALA415 |
| A | LEU416 |
| A | SER417 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 505 |
| Chain | Residue |
| A | TYR369 |
| A | HOH601 |
| A | HOH615 |
| A | HOH637 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 133 |
| Details | Domain: {"description":"GGDEF","evidences":[{"source":"PROSITE-ProRule","id":"PRU00095","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
