4ZM9
Crystal structure of circularly permuted human asparaginase-like protein 1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004067 | molecular_function | asparaginase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| B | 0004067 | molecular_function | asparaginase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| C | 0004067 | molecular_function | asparaginase activity |
| C | 0016787 | molecular_function | hydrolase activity |
| D | 0004067 | molecular_function | asparaginase activity |
| D | 0016787 | molecular_function | hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 401 |
| Chain | Residue |
| A | LEU55 |
| A | GLU56 |
| A | ASP58 |
| A | PHE61 |
| A | ALA63 |
| A | CYS65 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue GLY A 402 |
| Chain | Residue |
| A | ARG196 |
| A | ASP199 |
| A | SER200 |
| A | GLY220 |
| A | GLY222 |
| A | DTT407 |
| A | NA408 |
| A | HOH510 |
| A | THR168 |
| A | GLY188 |
| A | ILE189 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue BME A 403 |
| Chain | Residue |
| A | GLU239 |
| B | LEU233 |
| B | PHE236 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue BME A 404 |
| Chain | Residue |
| A | SER88 |
| A | ALA89 |
| A | VAL108 |
| A | MET109 |
| A | THR112 |
| A | HIS114 |
| A | CYS115 |
| B | LYS227 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue BME A 405 |
| Chain | Residue |
| A | BME406 |
| A | HOH519 |
| B | GLY36 |
| B | ARG39 |
| B | PRO308 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue BME A 406 |
| Chain | Residue |
| A | GLY26 |
| A | ARG29 |
| A | ALA54 |
| A | ASP58 |
| A | BME405 |
| B | PRO308 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue DTT A 407 |
| Chain | Residue |
| A | GLY11 |
| A | THR168 |
| A | VAL190 |
| A | THR219 |
| A | GLY220 |
| A | GLY402 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 408 |
| Chain | Residue |
| A | THR168 |
| A | ASP199 |
| A | SER200 |
| A | THR218 |
| A | GLY402 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue NA B 401 |
| Chain | Residue |
| B | LEU55 |
| B | GLU56 |
| B | ASP58 |
| B | PHE61 |
| B | ALA63 |
| B | CYS65 |
| site_id | AD1 |
| Number of Residues | 10 |
| Details | binding site for residue GLY B 402 |
| Chain | Residue |
| B | THR168 |
| B | GLY188 |
| B | ARG196 |
| B | ASP199 |
| B | SER200 |
| B | GLY220 |
| B | GLY222 |
| B | FLC403 |
| B | HOH505 |
| B | HOH507 |
| site_id | AD2 |
| Number of Residues | 8 |
| Details | binding site for residue FLC B 403 |
| Chain | Residue |
| B | GLY11 |
| B | ASN62 |
| B | ARG147 |
| B | THR168 |
| B | ILE189 |
| B | THR219 |
| B | GLY220 |
| B | GLY402 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for residue BME B 404 |
| Chain | Residue |
| A | LYS227 |
| B | SER88 |
| B | ALA89 |
| B | VAL108 |
| B | MET109 |
| B | THR112 |
| B | HIS114 |
| B | CYS115 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue NA C 401 |
| Chain | Residue |
| C | LEU55 |
| C | GLU56 |
| C | ASP58 |
| C | PHE61 |
| C | ALA63 |
| C | CYS65 |
| site_id | AD5 |
| Number of Residues | 10 |
| Details | binding site for residue GLY C 402 |
| Chain | Residue |
| C | THR168 |
| C | GLY188 |
| C | ARG196 |
| C | ASP199 |
| C | SER200 |
| C | GLY220 |
| C | GLY222 |
| C | ILE225 |
| C | NA409 |
| C | HOH506 |
| site_id | AD6 |
| Number of Residues | 8 |
| Details | binding site for residue BME C 403 |
| Chain | Residue |
| C | ALA89 |
| C | VAL108 |
| C | MET109 |
| C | THR112 |
| C | HIS114 |
| C | CYS115 |
| D | LYS227 |
| C | SER88 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue BME C 404 |
| Chain | Residue |
| C | GLY36 |
| C | HOH509 |
| D | ALA54 |
| D | ASP57 |
| site_id | AD8 |
| Number of Residues | 7 |
| Details | binding site for residue BME C 405 |
| Chain | Residue |
| C | VAL33 |
| C | GLY50 |
| C | ALA54 |
| C | HOH513 |
| D | THR32 |
| D | GLY36 |
| D | BME404 |
| site_id | AD9 |
| Number of Residues | 7 |
| Details | binding site for residue BME C 406 |
| Chain | Residue |
| C | GLY26 |
| C | ARG29 |
| C | ALA54 |
| C | LEU55 |
| C | ASP58 |
| D | PRO308 |
| D | BME404 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue DTT C 407 |
| Chain | Residue |
| C | GLY11 |
| C | ASN62 |
| C | THR168 |
| C | THR219 |
| C | GLY220 |
| site_id | AE2 |
| Number of Residues | 4 |
| Details | binding site for residue NA C 408 |
| Chain | Residue |
| C | ASP78 |
| C | ALA94 |
| C | LYS192 |
| C | ARG196 |
| site_id | AE3 |
| Number of Residues | 5 |
| Details | binding site for residue NA C 409 |
| Chain | Residue |
| C | THR168 |
| C | ASP199 |
| C | SER200 |
| C | THR218 |
| C | GLY402 |
| site_id | AE4 |
| Number of Residues | 6 |
| Details | binding site for residue NA D 401 |
| Chain | Residue |
| D | LEU55 |
| D | GLU56 |
| D | ASP58 |
| D | PHE61 |
| D | ALA63 |
| D | CYS65 |
| site_id | AE5 |
| Number of Residues | 11 |
| Details | binding site for residue GLY D 402 |
| Chain | Residue |
| D | THR168 |
| D | GLY188 |
| D | ILE189 |
| D | ARG196 |
| D | ASP199 |
| D | SER200 |
| D | GLY220 |
| D | GLY222 |
| D | FLC403 |
| D | HOH509 |
| D | HOH511 |
| site_id | AE6 |
| Number of Residues | 8 |
| Details | binding site for residue FLC D 403 |
| Chain | Residue |
| D | GLY11 |
| D | ASN62 |
| D | THR168 |
| D | GLY188 |
| D | ILE189 |
| D | THR219 |
| D | GLY220 |
| D | GLY402 |
| site_id | AE7 |
| Number of Residues | 6 |
| Details | binding site for residue BME D 404 |
| Chain | Residue |
| C | VAL53 |
| C | ALA54 |
| C | ASP57 |
| C | BME405 |
| C | BME406 |
| D | PRO308 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"19839645","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22861376","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | Binding site: {} |
| Chain | Residue | Details |
