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4ZK0

Psoriasis pathogenesis - Pso p27 constitute a compact structure forming large aggregates. High pH structure

Functional Information from GO Data
ChainGOidnamespacecontents
A0001618molecular_functionvirus receptor activity
A0002020molecular_functionprotease binding
A0004867molecular_functionserine-type endopeptidase inhibitor activity
A0004869molecular_functioncysteine-type endopeptidase inhibitor activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0008284biological_processpositive regulation of cell population proliferation
A0010466biological_processnegative regulation of peptidase activity
A0010718biological_processpositive regulation of epithelial to mesenchymal transition
A0010950biological_processpositive regulation of endopeptidase activity
A0010951biological_processnegative regulation of endopeptidase activity
A0030335biological_processpositive regulation of cell migration
A0031410cellular_componentcytoplasmic vesicle
A0031982cellular_componentvesicle
A0035425biological_processautocrine signaling
A0035578cellular_componentazurophil granule lumen
A0038001biological_processparacrine signaling
A0043086biological_processnegative regulation of catalytic activity
A0043508biological_processnegative regulation of JUN kinase activity
A0045861biological_processnegative regulation of proteolysis
A0046718biological_processsymbiont entry into host cell
A0070062cellular_componentextracellular exosome
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue ZN A 401
ChainResidue
AGLU64
AASP281
AHIS283
AHOH580

site_idAC2
Number of Residues3
Detailsbinding site for residue ZN A 402
ChainResidue
AGLU165
AHIS220
AGLU277

Functional Information from PROSITE/UniProt
site_idPS00284
Number of Residues11
DetailsSERPIN Serpins signature. FHCNHPFLFfI
ChainResidueDetails
APHE363-ILE373

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Reactive bond
ChainResidueDetails
ASER354

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N-acetylmethionine => ECO:0000269|Ref.13
ChainResidueDetails
AMET1

223790

PDB entries from 2024-08-14

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