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4Z47

Structure of the enzyme-product complex resulting from TDG action on a GU mismatch in the presence of excess base

Functional Information from GO Data
ChainGOidnamespacecontents
A0000700molecular_functionmismatch base pair DNA N-glycosylase activity
A0006285biological_processbase-excision repair, AP site formation
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue EDO A 401
ChainResidue
AASN131
ALEU132
AGLN223
AARG225

site_idAC2
Number of Residues5
Detailsbinding site for residue EDO A 402
ChainResidue
ALEU254
AGLN255
APRO256
ALYS258
ALEU265

site_idAC3
Number of Residues5
Detailsbinding site for residue EDO A 403
ChainResidue
ALEU295
AGLN298
ALEU299
AILE302
DHOH105

site_idAC4
Number of Residues9
Detailsbinding site for residue ACY A 404
ChainResidue
AGLY138
AILE139
AASN140
ATYR152
AASN191
AHOH514
AHOH555
AHOH595
DORP17

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS248

Catalytic Information from CSA
site_idMCSA1
Number of Residues2
DetailsM-CSA 834
ChainResidueDetails
AASN140electrostatic interaction
AHIS151proton acceptor, proton donor

226707

PDB entries from 2024-10-30

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