4Z47

Structure of the enzyme-product complex resulting from TDG action on a GU mismatch in the presence of excess base

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000700	molecular_function	mismatch base pair DNA N-glycosylase activity
A	0006285	biological_process	base-excision repair, AP site formation

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue EDO A 401

Chain	Residue
A	ASN131
A	LEU132
A	GLN223
A	ARG225

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site_id	AC2
Number of Residues	5
Details	binding site for residue EDO A 402

Chain	Residue
A	LEU254
A	GLN255
A	PRO256
A	LYS258
A	LEU265

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site_id	AC3
Number of Residues	5
Details	binding site for residue EDO A 403

Chain	Residue
A	LEU295
A	GLN298
A	LEU299
A	ILE302
D	HOH105

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site_id	AC4
Number of Residues	9
Details	binding site for residue ACY A 404

Chain	Residue
A	GLY138
A	ILE139
A	ASN140
A	TYR152
A	ASN191
A	HOH514
A	HOH555
A	HOH595
D	ORP17

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	2
Details	M-CSA 834

Chain	Residue	Details
A	ASN140	electrostatic interaction
A	HIS151	proton acceptor, proton donor

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