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4Z32

Crystal Structure of the FERM-SH2 Domains of Jak2

Functional Information from GO Data
ChainGOidnamespacecontents
A0004715molecular_functionnon-membrane spanning protein tyrosine kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
A0016020cellular_componentmembrane
A0035556biological_processintracellular signal transduction
A0042393molecular_functionhistone binding
B0004715molecular_functionnon-membrane spanning protein tyrosine kinase activity
B0005524molecular_functionATP binding
B0006468biological_processprotein phosphorylation
B0016020cellular_componentmembrane
B0035556biological_processintracellular signal transduction
B0042393molecular_functionhistone binding
C0004715molecular_functionnon-membrane spanning protein tyrosine kinase activity
C0005524molecular_functionATP binding
C0006468biological_processprotein phosphorylation
C0016020cellular_componentmembrane
C0035556biological_processintracellular signal transduction
C0042393molecular_functionhistone binding
D0004715molecular_functionnon-membrane spanning protein tyrosine kinase activity
D0005524molecular_functionATP binding
D0006468biological_processprotein phosphorylation
D0016020cellular_componentmembrane
D0035556biological_processintracellular signal transduction
D0042393molecular_functionhistone binding
E0004715molecular_functionnon-membrane spanning protein tyrosine kinase activity
E0005524molecular_functionATP binding
E0006468biological_processprotein phosphorylation
E0016020cellular_componentmembrane
E0035556biological_processintracellular signal transduction
E0042393molecular_functionhistone binding
F0004715molecular_functionnon-membrane spanning protein tyrosine kinase activity
F0005524molecular_functionATP binding
F0006468biological_processprotein phosphorylation
F0016020cellular_componentmembrane
F0035556biological_processintracellular signal transduction
F0042393molecular_functionhistone binding
G0004715molecular_functionnon-membrane spanning protein tyrosine kinase activity
G0005524molecular_functionATP binding
G0006468biological_processprotein phosphorylation
G0016020cellular_componentmembrane
G0035556biological_processintracellular signal transduction
G0042393molecular_functionhistone binding
H0004715molecular_functionnon-membrane spanning protein tyrosine kinase activity
H0005524molecular_functionATP binding
H0006468biological_processprotein phosphorylation
H0016020cellular_componentmembrane
H0035556biological_processintracellular signal transduction
H0042393molecular_functionhistone binding
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues243
DetailsDomain: {"description":"SH2; atypical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00191","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues28
DetailsSite: {"description":"Breakpoint for translocation to form PCM1-JAK2 fusion protein"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues8
DetailsModified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"UniProtKB","id":"Q62120","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues16
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q62120","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

239492

PDB entries from 2025-07-30

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