Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4Z32

Crystal Structure of the FERM-SH2 Domains of Jak2

Functional Information from GO Data
ChainGOidnamespacecontents
A0004715molecular_functionnon-membrane spanning protein tyrosine kinase activity
A0005524molecular_functionATP binding
A0005856cellular_componentcytoskeleton
A0006468biological_processprotein phosphorylation
A0016020cellular_componentmembrane
A0035556biological_processintracellular signal transduction
A0042393molecular_functionhistone binding
B0004715molecular_functionnon-membrane spanning protein tyrosine kinase activity
B0005524molecular_functionATP binding
B0005856cellular_componentcytoskeleton
B0006468biological_processprotein phosphorylation
B0016020cellular_componentmembrane
B0035556biological_processintracellular signal transduction
B0042393molecular_functionhistone binding
C0004715molecular_functionnon-membrane spanning protein tyrosine kinase activity
C0005524molecular_functionATP binding
C0005856cellular_componentcytoskeleton
C0006468biological_processprotein phosphorylation
C0016020cellular_componentmembrane
C0035556biological_processintracellular signal transduction
C0042393molecular_functionhistone binding
D0004715molecular_functionnon-membrane spanning protein tyrosine kinase activity
D0005524molecular_functionATP binding
D0005856cellular_componentcytoskeleton
D0006468biological_processprotein phosphorylation
D0016020cellular_componentmembrane
D0035556biological_processintracellular signal transduction
D0042393molecular_functionhistone binding
E0004715molecular_functionnon-membrane spanning protein tyrosine kinase activity
E0005524molecular_functionATP binding
E0005856cellular_componentcytoskeleton
E0006468biological_processprotein phosphorylation
E0016020cellular_componentmembrane
E0035556biological_processintracellular signal transduction
E0042393molecular_functionhistone binding
F0004715molecular_functionnon-membrane spanning protein tyrosine kinase activity
F0005524molecular_functionATP binding
F0005856cellular_componentcytoskeleton
F0006468biological_processprotein phosphorylation
F0016020cellular_componentmembrane
F0035556biological_processintracellular signal transduction
F0042393molecular_functionhistone binding
G0004715molecular_functionnon-membrane spanning protein tyrosine kinase activity
G0005524molecular_functionATP binding
G0005856cellular_componentcytoskeleton
G0006468biological_processprotein phosphorylation
G0016020cellular_componentmembrane
G0035556biological_processintracellular signal transduction
G0042393molecular_functionhistone binding
H0004715molecular_functionnon-membrane spanning protein tyrosine kinase activity
H0005524molecular_functionATP binding
H0005856cellular_componentcytoskeleton
H0006468biological_processprotein phosphorylation
H0016020cellular_componentmembrane
H0035556biological_processintracellular signal transduction
H0042393molecular_functionhistone binding
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues32
DetailsSITE: Breakpoint for translocation to form PCM1-JAK2 fusion protein
ChainResidueDetails
ALEU352
CGLU442
CLYS450
CLYS504
DLEU352
DGLU442
DLYS450
DLYS504
ELEU352
EGLU442
ELYS450
AGLU442
ELYS504
FLEU352
FGLU442
FLYS450
FLYS504
GLEU352
GGLU442
GLYS450
GLYS504
HLEU352
ALYS450
HGLU442
HLYS450
HLYS504
ALYS504
BLEU352
BGLU442
BLYS450
BLYS504
CLEU352

site_idSWS_FT_FI2
Number of Residues8
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000250|UniProtKB:Q62120
ChainResidueDetails
ATYR119
BTYR119
CTYR119
DTYR119
ETYR119
FTYR119
GTYR119
HTYR119

site_idSWS_FT_FI3
Number of Residues16
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q62120
ChainResidueDetails
ATYR372
ETYR373
FTYR372
FTYR373
GTYR372
GTYR373
HTYR372
HTYR373
ATYR373
BTYR372
BTYR373
CTYR372
CTYR373
DTYR372
DTYR373
ETYR372

227111

PDB entries from 2024-11-06

PDB statisticsPDBj update infoContact PDBjnumon