4Z32

Crystal Structure of the FERM-SH2 Domains of Jak2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
A	0016020	cellular_component	membrane
A	0035556	biological_process	intracellular signal transduction
A	0042393	molecular_function	histone binding
B	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
B	0016020	cellular_component	membrane
B	0035556	biological_process	intracellular signal transduction
B	0042393	molecular_function	histone binding
C	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
C	0016020	cellular_component	membrane
C	0035556	biological_process	intracellular signal transduction
C	0042393	molecular_function	histone binding
D	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation
D	0016020	cellular_component	membrane
D	0035556	biological_process	intracellular signal transduction
D	0042393	molecular_function	histone binding
E	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
E	0005524	molecular_function	ATP binding
E	0006468	biological_process	protein phosphorylation
E	0016020	cellular_component	membrane
E	0035556	biological_process	intracellular signal transduction
E	0042393	molecular_function	histone binding
F	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
F	0005524	molecular_function	ATP binding
F	0006468	biological_process	protein phosphorylation
F	0016020	cellular_component	membrane
F	0035556	biological_process	intracellular signal transduction
F	0042393	molecular_function	histone binding
G	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
G	0005524	molecular_function	ATP binding
G	0006468	biological_process	protein phosphorylation
G	0016020	cellular_component	membrane
G	0035556	biological_process	intracellular signal transduction
G	0042393	molecular_function	histone binding
H	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
H	0005524	molecular_function	ATP binding
H	0006468	biological_process	protein phosphorylation
H	0016020	cellular_component	membrane
H	0035556	biological_process	intracellular signal transduction
H	0042393	molecular_function	histone binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	243
Details	Domain: {"description":"SH2; atypical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00191","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	28
Details	Site: {"description":"Breakpoint for translocation to form PCM1-JAK2 fusion protein"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"UniProtKB","id":"Q62120","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q62120","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---