4Z0I

Crystal structure of a tetramer of GluA2 ligand binding domains bound with glutamate at 1.45 Angstrom resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue GLU A 301

Chain	Residue
A	TYR61
A	TYR220
A	HOH467
A	HOH507
A	HOH513
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	GLY141
A	SER142
A	THR143
A	GLU193

---

site_id	AC2
Number of Residues	9
Details	binding site for residue PO4 A 302

Chain	Residue
A	SER140
A	LYS144
A	ARG148
A	PEG306
A	HOH410
A	HOH418
A	HOH419
A	HOH509
A	HOH593

---

site_id	AC3
Number of Residues	4
Details	binding site for residue PO4 A 303

Chain	Residue
A	HIS46
A	LYS240
A	HOH470
A	HOH473

---

site_id	AC4
Number of Residues	2
Details	binding site for residue PO4 A 304

Chain	Residue
A	ARG64
A	LYS69

---

site_id	AC5
Number of Residues	12
Details	binding site for residue PG4 A 305

Chain	Residue
A	GLY1
A	LYS117
A	GLU201
A	GLN202
A	TYR256
A	CYS261
A	GLY262
A	SER263
A	HOH447
A	HOH495
A	HOH523
A	HOH650

---

site_id	AC6
Number of Residues	8
Details	binding site for residue PEG A 306

Chain	Residue
A	ASP139
A	LYS144
A	SER168
A	PHE170
A	PO4302
A	HOH419
A	HOH456
B	LYS185

---

site_id	AC7
Number of Residues	13
Details	binding site for residue GLU B 301

Chain	Residue
B	TYR61
B	PRO89
B	LEU90
B	THR91
B	ARG96
B	GLY141
B	SER142
B	THR143
B	GLU193
B	TYR220
B	HOH416
B	HOH499
B	HOH526

---

site_id	AC8
Number of Residues	10
Details	binding site for residue PO4 B 302

Chain	Residue
B	SER140
B	LYS144
B	ARG148
B	HOH434
B	HOH449
B	HOH455
B	HOH502
B	HOH520
B	HOH675
B	HOH678

---

site_id	AC9
Number of Residues	4
Details	binding site for residue PO4 B 303

Chain	Residue
B	HIS46
B	LYS240
B	HOH470
B	HOH528

---

site_id	AD1
Number of Residues	8
Details	binding site for residue PO4 B 304

Chain	Residue
B	ARG203
B	LYS258
B	HOH403
B	HOH413
B	HOH421
B	HOH425
B	HOH619
B	HOH654

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---