4YYL

Phenolic acid derivative bound to influenza strain H1N1 polymerase subunit PA endonuclease

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0039694	biological_process	viral RNA genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue 4KN A 301

Chain	Residue
A	TYR24
A	LYS134
A	4KN302
A	MN304
A	MN305
A	HOH433
A	HIS41
A	GLU80
A	ARG84
A	PHE105
A	LEU106
A	ASP108
A	GLU119
A	ILE120

---

site_id	AC2
Number of Residues	11
Details	binding site for residue 4KN A 302

Chain	Residue
A	THR20
A	GLU26
A	LYS34
A	ALA37
A	ILE38
A	HIS41
A	GLY121
A	VAL122
A	TYR130
A	4KN301
A	4KN303

---

site_id	AC3
Number of Residues	10
Details	binding site for residue 4KN A 303

Chain	Residue
A	GLU31
A	LYS34
A	ALA37
A	ARG124
A	PHE150
A	PHE191
A	SER194
A	GLU195
A	4KN302
A	HOH407

---

site_id	AC4
Number of Residues	6
Details	binding site for residue MN A 304

Chain	Residue
A	HIS41
A	ASP108
A	GLU119
A	ILE120
A	4KN301
A	MN305

---

site_id	AC5
Number of Residues	6
Details	binding site for residue MN A 305

Chain	Residue
A	GLU80
A	ASP108
A	4KN301
A	MN304
A	HOH433
A	HOH455

---

site_id	AC6
Number of Residues	4
Details	binding site for residue SO4 A 306

Chain	Residue
A	ARG124
A	ARG179
A	TRP188
A	ARG192

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_04063, ECO:0000269|PubMed:26252962, ECO:0000269|PubMed:27088785, ECO:0007744|PDB:4YYL, ECO:0007744|PDB:4ZI0, ECO:0007744|PDB:4ZQQ

Chain	Residue	Details
A	HIS41
A	ILE120

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_04063, ECO:0000269|PubMed:27088785, ECO:0007744|PDB:4YYL, ECO:0007744|PDB:4ZI0, ECO:0007744|PDB:4ZQQ

Chain	Residue	Details
A	GLU80
A	ASP108
A	GLU119

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