4YYE
Crystal structure of the yeast mitochondrial threonyl-tRNA synthetase (MST1) in complex with the canonical tRNAThr and threonyl sulfamoyl adenylate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004829 | molecular_function | threonine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0006412 | biological_process | translation |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006435 | biological_process | threonyl-tRNA aminoacylation |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0070159 | biological_process | mitochondrial threonyl-tRNA aminoacylation |
| A | 0140101 | molecular_function | catalytic activity, acting on a tRNA |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004829 | molecular_function | threonine-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0006412 | biological_process | translation |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006435 | biological_process | threonyl-tRNA aminoacylation |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0070159 | biological_process | mitochondrial threonyl-tRNA aminoacylation |
| B | 0140101 | molecular_function | catalytic activity, acting on a tRNA |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 501 |
| Chain | Residue |
| A | CYS133 |
| A | HIS184 |
| A | HIS319 |
| A | TSB502 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | binding site for residue TSB A 502 |
| Chain | Residue |
| A | ARG174 |
| A | LEU175 |
| A | PHE178 |
| A | GLN180 |
| A | ASP182 |
| A | HIS184 |
| A | TYR270 |
| A | GLN287 |
| A | VAL288 |
| A | THR290 |
| A | GLN292 |
| A | HIS319 |
| A | GLY324 |
| A | SER325 |
| A | ARG328 |
| A | ZN501 |
| A | MET131 |
| A | CYS133 |
| A | ARG162 |
| A | GLU164 |
| A | THR173 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 503 |
| Chain | Residue |
| A | TRP390 |
| A | LYS459 |
| A | HOH689 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 504 |
| Chain | Residue |
| A | THR188 |
| A | PRO189 |
| A | SER190 |
| A | HOH601 |
| A | HOH609 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 505 |
| Chain | Residue |
| A | PHE225 |
| A | ASN227 |
| A | LYS261 |
| A | MET277 |
| A | THR285 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 501 |
| Chain | Residue |
| B | CYS133 |
| B | HIS184 |
| B | HIS319 |
| B | TSB502 |
| site_id | AC7 |
| Number of Residues | 21 |
| Details | binding site for residue TSB B 502 |
| Chain | Residue |
| B | MET131 |
| B | CYS133 |
| B | ARG162 |
| B | GLU164 |
| B | THR173 |
| B | ARG174 |
| B | LEU175 |
| B | PHE178 |
| B | GLN180 |
| B | ASP182 |
| B | HIS184 |
| B | TYR270 |
| B | GLN287 |
| B | VAL288 |
| B | GLN292 |
| B | HIS319 |
| B | GLY324 |
| B | SER325 |
| B | ARG328 |
| B | ZN501 |
| B | HOH703 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 503 |
| Chain | Residue |
| B | ILE236 |
| B | GLY237 |
| B | ARG300 |
| B | HOH606 |
