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4YUV

Crystal structure of Trypanosoma cruzi spermidine synthase in complex with decarboxylated S-adenosylmethionine

Functional Information from GO Data
ChainGOidnamespacecontents
A0003824molecular_functioncatalytic activity
A0004766molecular_functionspermidine synthase activity
A0005829cellular_componentcytosol
A0006596biological_processpolyamine biosynthetic process
A0008295biological_processspermidine biosynthetic process
A0016740molecular_functiontransferase activity
B0003824molecular_functioncatalytic activity
B0004766molecular_functionspermidine synthase activity
B0005829cellular_componentcytosol
B0006596biological_processpolyamine biosynthetic process
B0008295biological_processspermidine biosynthetic process
B0016740molecular_functiontransferase activity
Functional Information from PDB Data
site_idAC1
Number of Residues21
Detailsbinding site for residue S4M A 501
ChainResidue
AGLN40
AILE119
AASP120
AVAL123
AASP149
AGLY150
AASP168
ATHR169
ATHR170
APRO175
AALA176
ALEU59
ALEU179
ATYR237
AGLN64
ATYR73
AHIS74
AGLY95
AASP98
AVAL117
AASP118

site_idAC2
Number of Residues20
Detailsbinding site for residue S4M B 501
ChainResidue
BGLN40
BLEU59
BGLN64
BTYR73
BHIS74
BGLY95
BASP98
BASP118
BILE119
BASP120
BVAL123
BASP149
BGLY150
BASP168
BTHR169
BTHR170
BPRO175
BALA176
BLEU179
BTYR237

Functional Information from PROSITE/UniProt
site_idPS01330
Number of Residues14
DetailsPABS_1 Polyamine biosynthesis (PABS) domain signature. VLIIGGGdGgvLrE
ChainResidueDetails
AVAL91-GLU104

243531

PDB entries from 2025-10-22

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