4YNQ

TREX1-dsDNA complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0008408	molecular_function	3'-5' exonuclease activity
B	0003676	molecular_function	nucleic acid binding
B	0008408	molecular_function	3'-5' exonuclease activity
C	0003676	molecular_function	nucleic acid binding
C	0008408	molecular_function	3'-5' exonuclease activity
D	0003676	molecular_function	nucleic acid binding
D	0008408	molecular_function	3'-5' exonuclease activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue MG A 301

Chain	Residue
A	ASN18
A	HOH401
E	DC23
E	DG24

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site_id	AC2
Number of Residues	6
Details	binding site for residue MG B 301

Chain	Residue
F	DG24
B	ASN18
B	HOH403
B	HOH406
B	HOH407
F	DC23

---

site_id	AC3
Number of Residues	5
Details	binding site for residue MG C 301

Chain	Residue
C	ASN18
C	HOH403
C	HOH405
H	DC23
H	DG24

---

site_id	AC4
Number of Residues	5
Details	binding site for residue MG D 301

Chain	Residue
D	ASN18
D	HIS124
D	HOH401
G	DC23
G	DG24

---

site_id	AC5
Number of Residues	5
Details	binding site for residue DT H 101

Chain	Residue
B	ARG128
F	DG21
F	DA22
F	DC23
H	DG21

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:17355961

Chain	Residue	Details
A	HIS195
B	HIS195
C	HIS195
D	HIS195

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site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269|PubMed:17293595, ECO:0000269|PubMed:17355961, ECO:0000269|PubMed:18780819, ECO:0000269|PubMed:22071149

Chain	Residue	Details
B	ASN18
B	GLU20
B	TYR129
B	ASP200
C	ASN18
C	GLU20
C	TYR129
C	ASP200
D	ASN18
D	GLU20
D	TYR129
D	ASP200
A	ASN18
A	GLU20
A	TYR129
A	ASP200

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9NSU2

Chain	Residue	Details
A	SER78
A	SER167
B	SER78
B	SER167
C	SER78
C	SER167
D	SER78
D	SER167

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