4YIG

vaccinia virus D4/A20(1-50) in complex with dsDNA containing an abasic site and free uracyl

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004844	molecular_function	uracil DNA N-glycosylase activity
A	0005515	molecular_function	protein binding
A	0006281	biological_process	DNA repair
A	0016787	molecular_function	hydrolase activity
A	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
A	0039693	biological_process	viral DNA genome replication
E	0003677	molecular_function	DNA binding
E	0004844	molecular_function	uracil DNA N-glycosylase activity
E	0005515	molecular_function	protein binding
E	0006281	biological_process	DNA repair
E	0016787	molecular_function	hydrolase activity
E	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
E	0039693	biological_process	viral DNA genome replication
I	0003677	molecular_function	DNA binding
I	0004844	molecular_function	uracil DNA N-glycosylase activity
I	0005515	molecular_function	protein binding
I	0006281	biological_process	DNA repair
I	0016787	molecular_function	hydrolase activity
I	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
I	0039693	biological_process	viral DNA genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue URA A 301

Chain	Residue
A	GLY66
C	ORP5
A	ILE67
A	ASP68
A	TYR70
A	PRO78
A	PHE79
A	ASN120
A	HIS181
A	HOH402

---

site_id	AC2
Number of Residues	10
Details	binding site for residue URA E 301

Chain	Residue
E	GLY66
E	ILE67
E	ASP68
E	TYR70
E	PRO78
E	PHE79
E	SER88
E	ASN120
E	HIS181
G	ORP5

---

site_id	AC3
Number of Residues	9
Details	binding site for residue URA I 301

Chain	Residue
I	GLY66
I	ILE67
I	ASP68
I	TYR70
I	PRO78
I	PHE79
I	ASN120
I	HIS181
K	ORP5

---

site_id	AC4
Number of Residues	20
Details	binding site for Poly-Saccharide residues DT C 4 through DA C 6

Chain	Residue
A	ASP68
A	PRO69
A	TYR70
A	PRO71
A	LYS72
A	LYS86
A	LYS87
A	SER88
A	THR130
A	HIS181
A	ARG185
A	URA301
A	HOH407
C	DG3
C	DT7
C	HOH103
C	HOH102
D	DA25
D	DT26
D	DA28

---

site_id	AC5
Number of Residues	36
Details	binding site for Poly-Saccharide residues DT G 4 through DA G 6

Chain	Residue
A	ASP68
A	PRO69
A	TYR70
A	PRO71
A	LYS72
A	LYS86
A	LYS87
A	SER88
A	THR130
A	HIS181
A	ARG185
A	URA301
A	HOH407
C	DG3
C	DT7
C	HOH103
C	HOH102
D	DA25
D	DT26
D	DA28
E	ASP68
E	PRO69
E	TYR70
E	PRO71
E	LYS86
E	LYS87
E	SER88
E	THR130
E	HIS181
E	ARG185
E	URA301
G	DG3
G	DT7
H	DA25
H	DT26
H	DA28

---

site_id	AC6
Number of Residues	34
Details	binding site for Poly-Saccharide residues DT K 4 through DA K 6

Chain	Residue
H	DT26
H	DA28
I	ASP68
I	PRO69
I	TYR70
I	PRO71
I	LYS72
I	LYS87
I	SER88
I	THR130
I	HIS181
I	ALA183
I	ARG185
I	URA301
I	HOH404
K	DG3
K	DT7
L	DA25
L	DT26
L	DA28
E	ASP68
E	PRO69
E	TYR70
E	PRO71
E	LYS86
E	LYS87
E	SER88
E	THR130
E	HIS181
E	ARG185
E	URA301
G	DG3
G	DT7
H	DA25

---

Functional Information from PROSITE/UniProt

site_id	PS00130
Number of Residues	10
Details	U_DNA_GLYCOSYLASE Uracil-DNA glycosylase signature. RVCVcGIDPY

Chain	Residue	Details
A	ARG61-TYR70

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10072

Chain	Residue	Details
A	ASP68
E	ASP68
I	ASP68

---