4YBH

Crystal structure of the human RAGE ectodomain (VC1C2 fragment) in complex with human S100A6

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0001726	cellular_component	ruffle
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005523	molecular_function	tropomyosin binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005635	cellular_component	nuclear envelope
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0007165	biological_process	signal transduction
B	0007409	biological_process	axonogenesis
B	0008270	molecular_function	zinc ion binding
B	0009898	cellular_component	cytoplasmic side of plasma membrane
B	0015075	molecular_function	monoatomic ion transmembrane transporter activity
B	0031012	cellular_component	extracellular matrix
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0044548	molecular_function	S100 protein binding
B	0046872	molecular_function	metal ion binding
B	0048146	biological_process	positive regulation of fibroblast proliferation
B	0048306	molecular_function	calcium-dependent protein binding
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 401

Chain	Residue
A	ASP160
A	ASP201
A	CL406
A	CL407

---

site_id	AC2
Number of Residues	3
Details	binding site for residue ZN A 402

Chain	Residue
A	ASP128
A	HIS180
A	GLU182

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 403

Chain	Residue
A	HOH507
A	HOH550
A	GLU32
A	HIS217

---

site_id	AC4
Number of Residues	3
Details	binding site for residue ZN A 404

Chain	Residue
A	HIS270
A	CL408
A	HOH544

---

site_id	AC5
Number of Residues	6
Details	binding site for residue CL A 405

Chain	Residue
A	GLU132
A	ARG228
A	ZN412
B	PHE16
B	HIS17
B	HIS27

---

site_id	AC6
Number of Residues	4
Details	binding site for residue CL A 406

Chain	Residue
A	ASP160
A	ASP201
A	ZN401
A	CL407

---

site_id	AC7
Number of Residues	6
Details	binding site for residue CL A 407

Chain	Residue
A	ASP160
A	ASP201
A	ZN401
A	CL406
A	HOH640
B	HOH206

---

site_id	AC8
Number of Residues	2
Details	binding site for residue CL A 408

Chain	Residue
A	HIS270
A	ZN404

---

site_id	AC9
Number of Residues	1
Details	binding site for residue ACT A 409

Chain	Residue
A	LYS169

---

site_id	AD1
Number of Residues	4
Details	binding site for residue ACT A 410

Chain	Residue
A	ARG77
A	LEU79
A	VAL302
A	THR304

---

site_id	AD2
Number of Residues	4
Details	binding site for residue ACT A 411

Chain	Residue
A	THR55
A	ARG57
A	TRP72
A	ASP93

---

site_id	AD3
Number of Residues	4
Details	binding site for residue ZN A 412

Chain	Residue
A	GLU132
A	CL405
B	HIS17
B	HIS27

---

site_id	AD4
Number of Residues	5
Details	binding site for residue ZN B 101

Chain	Residue
B	CYS3
B	ARG55
B	ASP59
B	HOH201
B	HOH205

---

site_id	AD5
Number of Residues	2
Details	binding site for residue ZN B 102

Chain	Residue
B	GLU41
B	CL103

---

site_id	AD6
Number of Residues	2
Details	binding site for residue CL B 103

Chain	Residue
B	GLU41
B	ZN102

---

site_id	AD7
Number of Residues	6
Details	binding site for residue CA B 104

Chain	Residue
B	SER20
B	GLU23
B	ASP25
B	THR28
B	GLU33
B	HOH207

---

site_id	AD8
Number of Residues	6
Details	binding site for residue CA B 105

Chain	Residue
B	ASP61
B	ASN63
B	ASP65
B	GLU67
B	GLU72
B	HOH224

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DRNKDQEVNfqEY

Chain	Residue	Details
B	ASP61-TYR73

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCVATH

Chain	Residue	Details
A	TYR299-HIS305

---

site_id	PS00303
Number of Residues	22
Details	S100_CABP S-100/ICaBP type calcium binding protein signature. LMedLDrnkDqevNFqEYvtFL

Chain	Residue	Details
B	LEU56-LEU77

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	93
Details	Domain: {"description":"Ig-like V-type"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	97
Details	Domain: {"description":"Ig-like C2-type 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	90
Details	Domain: {"description":"Ig-like C2-type 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	35
Details	Domain: {"description":"EF-hand 1","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	35
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P14069","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---