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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4YAY

XFEL structure of human Angiotensin Receptor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004930	molecular_function	G protein-coupled receptor activity
A	0004945	molecular_function	angiotensin type II receptor activity
A	0005506	molecular_function	iron ion binding
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0009055	molecular_function	electron transfer activity
A	0016020	cellular_component	membrane
A	0019229	biological_process	regulation of vasoconstriction
A	0020037	molecular_function	heme binding
A	0022900	biological_process	electron transport chain
A	0042597	cellular_component	periplasmic space
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue ZD7 A 1201

Chain	Residue
A	TYR35
A	PHE182
A	ILE288
A	TYR292
A	TRP84
A	THR88
A	SER105
A	VAL108
A	SER109
A	LEU112
A	ALA163
A	ARG167

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASVfLLTCLSIDRYLaI

Chain	Residue	Details
A	ALA114-ILE130

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: axial binding residue

Chain	Residue	Details
A	TRP1007
A	ILE1102

site_id	SWS_FT_FI2
Number of Residues	29
Details	TRANSMEM: Helical; Name=1 => ECO:0000269\|PubMed:25913193, ECO:0000269\|PubMed:26420482, ECO:0000269\|PubMed:30639100, ECO:0000269\|PubMed:32079768, ECO:0007744\|PDB:4YAY, ECO:0007744\|PDB:4ZUD, ECO:0007744\|PDB:6DO1, ECO:0007744\|PDB:6OS0, ECO:0007744\|PDB:6OS1, ECO:0007744\|PDB:6OS2

Chain	Residue	Details
A	TYR26-PHE55

site_id	SWS_FT_FI3
Number of Residues	20
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:25913193, ECO:0000269\|PubMed:26420482, ECO:0000269\|PubMed:30639100, ECO:0000269\|PubMed:32079768, ECO:0007744\|PDB:4YAY, ECO:0007744\|PDB:4ZUD, ECO:0007744\|PDB:6DO1, ECO:0007744\|PDB:6OS0, ECO:0007744\|PDB:6OS1, ECO:0007744\|PDB:6OS2

Chain	Residue	Details
A	TYR56-THR61
A	ARG126-THR141

site_id	SWS_FT_FI4
Number of Residues	27
Details	TRANSMEM: Helical; Name=2 => ECO:0000269\|PubMed:25913193, ECO:0000269\|PubMed:26420482, ECO:0000269\|PubMed:30639100, ECO:0000269\|PubMed:32079768, ECO:0007744\|PDB:4YAY, ECO:0007744\|PDB:4ZUD, ECO:0007744\|PDB:6DO1, ECO:0007744\|PDB:6OS0, ECO:0007744\|PDB:6OS1, ECO:0007744\|PDB:6OS2

Chain	Residue	Details
A	VAL62-ALA89

site_id	SWS_FT_FI5
Number of Residues	32
Details	TOPO_DOM: Extracellular => ECO:0000269\|PubMed:25913193, ECO:0000269\|PubMed:26420482, ECO:0000269\|PubMed:30639100, ECO:0000269\|PubMed:32079768, ECO:0007744\|PDB:4YAY, ECO:0007744\|PDB:4ZUD, ECO:0007744\|PDB:6DO1, ECO:0007744\|PDB:6OS0, ECO:0007744\|PDB:6OS1, ECO:0007744\|PDB:6OS2

Chain	Residue	Details
A	MET90-ASN98
A	HIS166-THR190

site_id	SWS_FT_FI6
Number of Residues	26
Details	TRANSMEM: Helical; Name=3 => ECO:0000269\|PubMed:25913193, ECO:0000269\|PubMed:26420482, ECO:0000269\|PubMed:30639100, ECO:0000269\|PubMed:32079768, ECO:0007744\|PDB:4YAY, ECO:0007744\|PDB:4ZUD, ECO:0007744\|PDB:6DO1, ECO:0007744\|PDB:6OS0, ECO:0007744\|PDB:6OS1, ECO:0007744\|PDB:6OS2

Chain	Residue	Details
A	TYR99-ASP125

site_id	SWS_FT_FI7
Number of Residues	23
Details	TRANSMEM: Helical; Name=4 => ECO:0000269\|PubMed:25913193, ECO:0000269\|PubMed:26420482, ECO:0000269\|PubMed:30639100, ECO:0000269\|PubMed:32079768, ECO:0007744\|PDB:4YAY, ECO:0007744\|PDB:4ZUD, ECO:0007744\|PDB:6DO1, ECO:0007744\|PDB:6OS0, ECO:0007744\|PDB:6OS1, ECO:0007744\|PDB:6OS2

Chain	Residue	Details
A	MET142-ILE165

site_id	SWS_FT_FI8
Number of Residues	25
Details	TRANSMEM: Helical; Name=5 => ECO:0000269\|PubMed:25913193, ECO:0000269\|PubMed:26420482, ECO:0000269\|PubMed:30639100, ECO:0000269\|PubMed:32079768, ECO:0007744\|PDB:4YAY, ECO:0007744\|PDB:4ZUD, ECO:0007744\|PDB:6DO1, ECO:0007744\|PDB:6OS0, ECO:0007744\|PDB:6OS1, ECO:0007744\|PDB:6OS2

Chain	Residue	Details
A	LEU191-THR216

site_id	SWS_FT_FI9
Number of Residues	22
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:25913193, ECO:0000269\|PubMed:26420482, ECO:0007744\|PDB:4YAY, ECO:0007744\|PDB:4ZUD

Chain	Residue	Details
A	LEU217-PHE239

site_id	SWS_FT_FI10
Number of Residues	28
Details	TRANSMEM: Helical; Name=6 => ECO:0000269\|PubMed:25913193, ECO:0000269\|PubMed:26420482, ECO:0007744\|PDB:4YAY, ECO:0007744\|PDB:4ZUD

Chain	Residue	Details
A	LYS240-LEU268

site_id	SWS_FT_FI11
Number of Residues	9
Details	TOPO_DOM: Extracellular => ECO:0000269\|PubMed:25913193, ECO:0000269\|PubMed:26420482, ECO:0007744\|PDB:4YAY, ECO:0007744\|PDB:4ZUD

Chain	Residue	Details
A	GLY269-ASP278

site_id	SWS_FT_FI12
Number of Residues	25
Details	TRANSMEM: Helical; Name=7 => ECO:0000269\|PubMed:25913193, ECO:0000269\|PubMed:26420482, ECO:0007744\|PDB:4YAY, ECO:0007744\|PDB:4ZUD

Chain	Residue	Details
A	ILE279-PHE304

site_id	SWS_FT_FI13
Number of Residues	1
Details	BINDING: BINDING => ECO:0000305\|PubMed:30639100, ECO:0007744\|PDB:6DO1

Chain	Residue	Details
A	SER15

site_id	SWS_FT_FI14
Number of Residues	6
Details	BINDING: BINDING => ECO:0000305\|PubMed:30639100, ECO:0000305\|PubMed:32079768, ECO:0007744\|PDB:6DO1, ECO:0007744\|PDB:6OS0

Chain	Residue	Details
A	ASP17
A	ARG167
A	PHE182
A	HIS183
A	TYR184
A	LYS199

site_id	SWS_FT_FI15
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269\|PubMed:19139490

Chain	Residue	Details
A	ASN14

site_id	SWS_FT_FI16
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:30639100, ECO:0000269\|PubMed:32079768, ECO:0007744\|PDB:6DO1, ECO:0007744\|PDB:6OS0

Chain	Residue	Details
A	ASN176

site_id	SWS_FT_FI17
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN188

218853

PDB entries from 2024-04-24

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