4Y1T
Structural basis for Ca2+-mediated interaction of the perforin C2 domain with lipid membranes
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue CA A 601 |
| Chain | Residue |
| A | ASP429 |
| A | ASP435 |
| A | ASP483 |
| A | ALA484 |
| A | ASP485 |
| A | CA604 |
| A | HOH705 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 602 |
| Chain | Residue |
| A | ASP491 |
| A | HOH707 |
| A | HOH718 |
| A | ASP485 |
| A | ASP489 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 603 |
| Chain | Residue |
| A | ASP429 |
| A | THR432 |
| A | ALA433 |
| A | ASP435 |
| A | ASN454 |
| A | GLU467 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue CA A 604 |
| Chain | Residue |
| A | GLY428 |
| A | ASP429 |
| A | ASP483 |
| A | ASP485 |
| A | ASP491 |
| A | CA601 |
| A | HOH723 |
| A | HOH752 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 605 |
| Chain | Residue |
| A | ASP485 |
| A | ALA488 |
| A | ASP490 |
| A | HOH714 |
| A | HOH761 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26306037, ECO:0007744|PDB:4Y1T |
| Chain | Residue | Details |
| A | GLY428 | |
| A | THR432 | |
| A | ALA433 | |
| A | GLU467 | |
| A | ASP489 | |
| A | ASP491 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26306037, ECO:0000269|PubMed:35148176, ECO:0007744|PDB:4Y1T, ECO:0007744|PDB:7PAG |
| Chain | Residue | Details |
| A | ASP429 | |
| A | ASN454 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21037563, ECO:0000269|PubMed:26306037, ECO:0000269|PubMed:35148176, ECO:0007744|PDB:3NSJ, ECO:0007744|PDB:4Y1T, ECO:0007744|PDB:7PAG |
| Chain | Residue | Details |
| A | ASP435 | |
| A | ALA484 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21037563, ECO:0000269|PubMed:26306037, ECO:0007744|PDB:3NSJ, ECO:0007744|PDB:4Y1T |
| Chain | Residue | Details |
| A | ASP483 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21037563, ECO:0000269|PubMed:26306037, ECO:0007744|PDB:3NSJ, ECO:0007744|PDB:4Y1S |
| Chain | Residue | Details |
| A | ASP485 | |
| A | ASP490 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21037563, ECO:0007744|PDB:3NSJ |
| Chain | Residue | Details |
| A | ALA488 |
