4XZU
Crystal Structure of the Human Factor VIII C2 Domain in Complex with Murine 3E6 Inhibitory Antibody
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue MG A 301 |
| Chain | Residue |
| A | VAL130 |
| A | CYS131 |
| A | THR134 |
| A | THR135 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue MG M 2401 |
| Chain | Residue |
| M | TYR2195 |
| M | GLN2222 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue MG F 301 |
| Chain | Residue |
| F | SER120 |
| F | SER121 |
| F | GLU122 |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| B | TYR191-HIS197 |
| site_id | PS01285 |
| Number of Residues | 30 |
| Details | FA58C_1 Coagulation factors 5/8 type C domain (FA58C) signature 1. AWrpqvnnpke......WLqVDfqktmkVtgVtTQG |
| Chain | Residue | Details |
| M | ALA2218-GLY2247 |
| site_id | PS01286 |
| Number of Residues | 17 |
| Details | FA58C_2 Coagulation factors 5/8 type C domain (FA58C) signature 2. Pqswvhqia..LRmEVlGC |
| Chain | Residue | Details |
| M | PRO2310-CYS2326 |
