4XNW

The human P2Y1 receptor in complex with MRS2500

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004930	molecular_function	G protein-coupled receptor activity
A	0005506	molecular_function	iron ion binding
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
A	0009055	molecular_function	electron transfer activity
A	0016020	cellular_component	membrane
A	0030168	biological_process	platelet activation
A	0043448	biological_process	alkane catabolic process
A	0045028	molecular_function	G protein-coupled purinergic nucleotide receptor activity
A	0046872	molecular_function	metal ion binding
A	0090075	biological_process	relaxation of muscle
C	0004930	molecular_function	G protein-coupled receptor activity
C	0005506	molecular_function	iron ion binding
C	0007186	biological_process	G protein-coupled receptor signaling pathway
C	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
C	0009055	molecular_function	electron transfer activity
C	0016020	cellular_component	membrane
C	0030168	biological_process	platelet activation
C	0043448	biological_process	alkane catabolic process
C	0045028	molecular_function	G protein-coupled purinergic nucleotide receptor activity
C	0046872	molecular_function	metal ion binding
C	0090075	biological_process	relaxation of muscle

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	binding site for residue 2ID A 1101

Chain	Residue
A	CYS42
A	ASN283
A	ALA286
A	ARG287
A	GLN291
A	ASN299
A	TYR303
A	TYR306
A	ARG310
A	HOH1202
A	HOH1205
A	LEU44
A	LYS46
A	TYR110
A	ARG195
A	THR201
A	TYR203
A	ASP204
A	THR205

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 1102

Chain	Residue
A	CYS1006
A	CYS1009
A	CYS1039
A	CYS1042

---

site_id	AC3
Number of Residues	14
Details	binding site for residue 2ID C 1101

Chain	Residue
C	LYS46
C	TYR110
C	ARG195
C	THR201
C	ASP204
C	THR205
C	ASN283
C	ALA286
C	ARG287
C	GLN291
C	ASN299
C	TYR303
C	TYR306
C	ARG310

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN C 1102

Chain	Residue
C	CYS1006
C	CYS1009
C	CYS1039
C	CYS1042

---

Functional Information from PROSITE/UniProt

site_id	PS00202
Number of Residues	11
Details	RUBREDOXIN Rubredoxin signature. IpDDWvCPlCG

Chain	Residue	Details
A	ILE1033-GLY1043

---

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. GSIlFLTCISAHRYSgV

Chain	Residue	Details
A	GLY137-VAL153

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	106
Details	Domain: {"description":"Rubredoxin-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00241","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00241","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10216292","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"N-formylmethionine","evidences":[{"source":"PubMed","id":"1637309","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	44
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"25822790","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	60
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"25822790","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"25822790","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	116
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"25822790","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"25822790","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"25822790","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	44
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"25822790","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	46
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"25822790","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"25822790","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	22
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25822790","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4XNW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---